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The clinical burden of generalized osteoarthritis represented by self-reported health-related quality of life and activity limitations: a cross-sectional study

  • Original Article - Observational Research
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Abstract

The involvement of multiple joints is common in osteoarthritis (OA), often referred to as generalized osteoarthritis (GOA). However, since research and practice mainly focus on a specific OA localization, the health status of patients with GOA is largely unknown. Therefore, we aimed to describe the clinical burden of GOA in terms of self-reported health-related quality of life (HRQoL) and activity limitations. In this cross-sectional study, individuals clinically diagnosed with GOA and referred to multidisciplinary treatment, completed questionnaires on socio-demographics, joint involvement, HRQoL (SF-36) and activity limitations (HAQ-DI). SF-36 physical (PCS) and mental component summary scores (MCS) were calculated using norm-based data. The patient’s specific most important activity limitations were linked to the International Classification of Functioning, Disability and Health. A total of 147 patients participated [85 % female; mean (SD) age 60 (8) years]. The majority (93 %) had symptomatic OA in both the upper and lower extremities. Predominant joints with symptomatic OA were the hands (85 %) and knees (82 %). Mean (SD) SF-36 PCS and MCS scores were 37 (7) and 48 (10), respectively, showing a broad impact of GOA on the physical component of health. The mean (SD) HAQ-DI score was 1.27 (0.50) indicating moderate to severe functional limitations. Activities concerning mobility and domestic life were considered most important activity limitations, especially walking. The results show a high clinical burden of GOA in terms of HRQoL and activity limitations. This study points to the need of developing non-pharmacological interventions for patients with GOA that should target on improving the physical component of health and mobility limitations.

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Acknowledgments

We would like to thank all the participants of this study. Furthermore, we are grateful to Sylvia Karsenbarg and Dennis Konhuurne en Jasper Geerts for their contribution in the data collection.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Rheumatology, Sint Maartenskliniek, PO box 9011, 6500 GM, Nijmegen, The Netherlands

    Nienke Cuperus, Elien A. M. Mahler, Clarinda C. Kersten & Cornelia H. M. van den Ende

  2. Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands

    Thea P. M. Vliet Vlieland

  3. Department of Epidemiology, CAPHRI School for Public Health and Primary Care, CCTR Centre for Care Technology Research, Maastricht University, Maastricht, The Netherlands

    Thomas J. Hoogeboom

Authors
  1. Nienke Cuperus
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  2. Thea P. M. Vliet Vlieland
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  3. Elien A. M. Mahler
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  4. Clarinda C. Kersten
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  5. Thomas J. Hoogeboom
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  6. Cornelia H. M. van den Ende
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Correspondence to Nienke Cuperus.

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Cuperus, N., Vliet Vlieland, T.P.M., Mahler, E.A.M. et al. The clinical burden of generalized osteoarthritis represented by self-reported health-related quality of life and activity limitations: a cross-sectional study. Rheumatol Int 35, 871–877 (2015). https://doi.org/10.1007/s00296-014-3149-1

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  • DOI: https://doi.org/10.1007/s00296-014-3149-1

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