Skip to main content

Advertisement

Log in

The effect of sequel symptoms and signs of Complex Regional Pain Syndrome type 1 on upper extremity disability and quality of life

  • Original Article
  • Published:
Rheumatology International Aims and scope Submit manuscript

Abstract

Although properly treated, patients with Complex Regional Pain Syndrome type 1 (CRPS type 1) of upper limb may continue to have sequel signs and symptoms of the disease in long-term. The aim of this study is to analyse the effect of the sequel findings of CRPS type 1 on upper limb disability and quality of life. Thirty patients with CRPS type 1 of the upper extremity were re-evaluated for the sequel sign and symptoms of CRPS type 1 after 18 months (8–60 months). Pain, range of motion, strength, manual dexterity and touch perception thresholds of the hands, upper extremity disability [Disability of arm, shoulder and hand (DASH) questionnaire] and health-related quality of life [Short Form-36 (SF-36)] were measured and compared to 38 healthy controls. Of the 30 patients, only 3 patients (10%) were symptom free. Pain after use was the most frequently found symptom. Strength and range of motion of the involved hand was reduced in CRPS type 1 patients. Manual dexterity was impaired and touch perception threshold was elevated in CRPS type 1 patients. The involved upper extremities were more disabled in CRPS type 1 patients than controls. The severity of the pain, and numbness of the hands were the factors causing disability. Pain caused reduced quality of life in physical functioning. In conclusion, prolonged follow-up period and efforts to improve sensory disturbances (especially pain) may reduce the upper extremity disability and reduced quality of life in CRPS type 1 patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Stanton-Hicks M, Janig W, Hassenbusch S, Haddox JD, Boas R, Wilson P (1995) Reflex sympathetic dystrophy: changing concepts and taxonomy. Pain 63:127–133. doi:10.1016/0304-3959(95)00110-E

    Article  PubMed  CAS  Google Scholar 

  2. Zyluk A (2001) The sequelae of reflex sympathetic dystrophy. J Hand Surg 26:151–154

    CAS  Google Scholar 

  3. Zyluk A (1998) The natural history of post-traumatic reflex sympathetic dystrophy. J Hand Surg [Am] 23B:20–23

    Google Scholar 

  4. Anderson DJ, Fallat LM (1999) Complex regional pain syndrome of the lower extremity: a retrospective study of 33 patients. J Foot Ankle Surg 38(6):381–387

    Article  PubMed  CAS  Google Scholar 

  5. Stanton-Hicks MD, Burton AW, Bruehl SP, Carr DB, Harden NR, Hassenbush SJ et al (2002) An updated interdisciplinary clinical pathway for CRPS: report of an expert panel. Pain Pract 2(1):1–16. doi:10.1046/j.1533-2500.2002.02009.x

    Article  PubMed  Google Scholar 

  6. Hudak PL, Amadio PC, Bombardier C (1996) Development of upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand. Am J Int Med 29:602–608. doi:10.1002/(SICI)1097-0274(199606)29:6<602::AID-AJIM4>3.0.CO;2-L

    Article  CAS  Google Scholar 

  7. Ware JE, Sherbourne CD (1992) The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 30:473–483. doi:10.1097/00005650-199206000-00002

    Article  PubMed  Google Scholar 

  8. Koçyiğit H, Aydem Ö, Fişek G, Ölmez N, Memiş A (1999) Kısa form-36’nın türkçe versiyonunun güvenilirliği ve geçerliliği. Ilaç ve Tedavi Dergisi 12:102–106

    Google Scholar 

  9. Cambridge-Keeling CA (2002) Range-of-motion measurement of the hand. In: Hunter JM, Macken EJ, Callahan AD (eds) Rehabilitation of the hand and upper extremity. Mosby, USA, pp 169–182

    Google Scholar 

  10. Mathiowetz V, Weber K, Volland G, Kashman N (1984) Reliability and validity of grip and pinch strength evaluations. J Hand Surg 9A:222–226

    Google Scholar 

  11. Meyer A, Sagvolden T (2006) Fine motor skills in South African children with symptoms of ADHD: influence of subtype, gender, age, and hand dominance. Behav Brain Funct 9(2):33. doi:10.1186/1744-9081-2-33

    Article  Google Scholar 

  12. Bell-Krotoski JA (2002) Sensibility testing with the Semmes-Weinstein monofilaments. In: Hunter JM, Macken EJ, Callahan AD (eds) Rehabilitation of the hand and upper extremity. Mosby, USA, pp 194–213

    Google Scholar 

  13. Field J, Warwick D, Bannister GC (1992) Features of algodystrophy ten years after Colles’ fracture. J Hand Surg 17B:318–320

    Google Scholar 

  14. Bickerstaff DR, Kanis JA (1994) Algodystrophy: an under-recognized complication of minor trauma. Br J Rheumatol 33:240–246. doi:10.1093/rheumatology/33.3.240

    Article  PubMed  CAS  Google Scholar 

  15. Fielka VZ, Bochdansky T, Schneider B, Schimmerl S (1991) Late sequelae of reflex sympathetic dystrophy: results of clinical, scintigraphic and dynamometric investigations. Eur J Phys Med Rehabil 3:59–64

    Google Scholar 

  16. Galer BS, Henderson J, Perander J, Pensen MP (2000) Course of symptoms and quality of life measurement in complex regional pain syndrome: a pilot survey. J Pain Symptom Manage 20:286–292. doi:10.1016/S0885-3924(00)00183-4

    Article  PubMed  CAS  Google Scholar 

  17. Birklein F, Handwerker HO (2001) Complex regional pain syndrome: how to resolve the complexity? Pain 94:1–6. doi:10.1016/S0304-3959(01)00393-1

    Article  PubMed  CAS  Google Scholar 

  18. Heerschap A, den Hollander JA, Reynen H, Goris RJA (1993) Metabolic changes in reflex sympathetic dystrophy: a 31P NMR spectroscopy study. Muscle Nerve 16:367–373. doi:10.1002/mus.880160405

    Article  PubMed  CAS  Google Scholar 

  19. Jänig W, Baron R (2002) Complex regional pain syndrome is a disease of the central nervous system. Clin Auton Res 12:150–164. doi:10.1007/s10286-002-0022-1

    Article  PubMed  Google Scholar 

  20. Maihöfner C, Baron R, DeCol R, Binder A, Birklein F, Deuschl G et al (2007) The motor system shows adaptive changes in complex regional pain syndrome. Brain 130:2671–2687. doi:10.1093/brain/awm131

    Article  PubMed  Google Scholar 

  21. Krause P, Förderreuther S, Straube A (2006) TMS motor cortical brain mapping in patients with complex regional pain syndrome tpe 1. Clin Neurophysiol 117:169–176. doi:10.1016/j.clinph.2005.09.012

    Article  PubMed  Google Scholar 

  22. Maihöfner C, Handwerker HO, Neundörfer B, Birklein F (2004) Cortical reorganisation during recovery from complex regional pain syndrome. Neurology 63(4):693–701

    PubMed  Google Scholar 

  23. Lewis JS, Kersten P, McCabe CS, McPherson KM, Blake DR (2007) Body perception disturbance: a contribution to pain in complex regional pain syndrome (CRPS). Pain 133:111–119. doi:10.1016/j.pain.2007.03.013

    Article  PubMed  Google Scholar 

  24. Miahöfner C, Handwerker HO, Neundorfer B, Birklein F (2003) Patterns of cortical reorganisation in complex regional pain syndrome. Neurology 61:1707–1715

    Google Scholar 

  25. Pleger P, Tegenthoff M, Ragert P, Forster A, Dinse H, Schwenkreis P et al (2005) Sensorimotor returning in complex regional pain syndrome parallels pain reduction. Ann Neurol 57:425–429. doi:10.1002/ana.20394

    Article  PubMed  Google Scholar 

  26. Galer BS, Jensen M (1999) Neglect-like symptoms in complex regional pain syndrome: results of a self-administered survey. J Pain Symptom Manage 18:213–217. doi:10.1016/S0885-3924(99)00076-7

    Article  PubMed  CAS  Google Scholar 

  27. Veldman PH, Reynen HM, Arntz IE, Goris RJ (1993) Signs and symptoms of reflex sympathetic dystrophy: prospective study of 829 patients. Lancet 342:1012–1016. doi:10.1016/0140-6736(93)92877-V

    Article  PubMed  CAS  Google Scholar 

  28. Birklein F, Riedl B, Sieweke N, Weber M, Neundorfer B (2000) Neurological findings in complex regional pain syndromes-analysis of 145 cases. Acta Neurol Scand 101:262–269. doi:10.1034/j.1600-0404.2000.101004262x./

    Article  PubMed  CAS  Google Scholar 

  29. Juottonen K, Gockel M, Silén T, Hurri H, Hari R, Forss N (2002) Altered central sensorimotor processing in patients with complex regional pain syndrome. Pain 98:315–323. doi:10.1016/S0304-3959(02)00119-7

    Article  PubMed  Google Scholar 

  30. Geertzen JHB, Dijkstra PU (1998) Relationship between impairments, disability and handicap in reflex sympathetic dystrophy patients: a long-term follow-up study. Clin Rehabil 12:402–412. doi:10.1191/026921598676761735

    Article  PubMed  CAS  Google Scholar 

  31. Subbarao J, Stillwell GK (1981) Reflex sympathetic dystrophy of the upper extremity: analysis of total outcome of management of 125 cases. Arch Phys Med Rehabil 62(11):549–554

    PubMed  CAS  Google Scholar 

  32. Kemler MA, de Vet HCW (2000) Health-related quality of life in chronic refractory reflex sympathetic dystrophy (complex regional pain syndrome type 1). J Pain Symptom Manage 20:68–76. doi:10.1016/S0885-3924(00)00170-6

    Article  PubMed  CAS  Google Scholar 

  33. Puchalski P, Zyluk A (2005) Complex regional pain syndrome type 1 after fractures of the distal radius: a prospective study of the role of psychological factors. J Hand Surg 30(6):574–580

    CAS  Google Scholar 

  34. Ciccone DS, Bandilla EB, Wu WH (1997) Psychological dysfunction in patients with reflex sympathetic dystrophy. Pain 71:323–333. doi:10.1016/S0304-3959(97)00009-2

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

We thank Ersin Uskun, MD., for her expert statistical assistance.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Serpil Savaş.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Savaş, S., Baloğlu, H.H., Ay, G. et al. The effect of sequel symptoms and signs of Complex Regional Pain Syndrome type 1 on upper extremity disability and quality of life. Rheumatol Int 29, 545–550 (2009). https://doi.org/10.1007/s00296-008-0748-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00296-008-0748-8

Keywords

Navigation