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Transfer of maternal immunity and programming of the newborn immune system

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Abstract

As placental mammals, the pregnant women and the fetus have intense and prolonged interactions during gestation. There is increasing evidence that multiple molecular as well as cellular components originating in pregnant women are transferred to the fetus. The transfer of maternal antibodies has long been recognized as a central component of newborn immunity against pathogens. More recent studies indicate that inflammatory mediators, micronutrients, microbial products and maternal cells are transferred in utero and influence the fetal immune system. Together, these multiple signals are likely to form a complex network of interactions that program the neonatal immune system and tune its homeostatic regulation. Maternal disorders, in particular infectious diseases, modify these signals and may thereby alter immunity in early life. Understanding maternal programming of the newborn immune system could provide a basis for interventions promoting child health.

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Acknowledgements

A.M. is research director at the Fund for Scientific Research, F.R.S.-FNRS, Belgium.

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Authors and Affiliations

  1. Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA

    Madeleine F. Jennewein & Galit Alter

  2. Vaccine Evaluation Center, BC Childrenʼs Hospital, Department of Pediatrics, Division of Infectious Diseases, University of British Columbia, Vancouver, BC, Canada

    Bahaa Abu-Raya

  3. Institute for Medical Immunology, Université Libre de Bruxelles, Rue Adrienne Bolland 8, 6041 Gosselies, Charleroi, Belgium

    Yiwei Jiang & Arnaud Marchant

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  1. Madeleine F. Jennewein
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  2. Bahaa Abu-Raya
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  3. Yiwei Jiang
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  4. Galit Alter
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  5. Arnaud Marchant
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Correspondence to Arnaud Marchant.

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This article is a contribution to the special issue on Immunocompetence of the Newborn - Guest Editors: Arnaud Marchant and Tobias Kollmann

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Jennewein, M.F., Abu-Raya, B., Jiang, Y. et al. Transfer of maternal immunity and programming of the newborn immune system. Semin Immunopathol 39, 605–613 (2017). https://doi.org/10.1007/s00281-017-0653-x

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