Abstract
Efforts to collect evidence of human pheromones have focused on three partly overlapping classes of possible human pheromones: (1) axillary steroids, (2) vaginal aliphatic acids, and (3) stimulators of the vomeronasal organ. Examples of each of these classes have been patented for commercial use, and in some cases aggressively marketed, but there is only incomplete evidence supporting any particular claim that a substance acts as a human pheromone. The large axillary scent glands found in humans appear to be well adapted for the production of pheromones, but may actually be used for non-pheromonal odor communication, such as the sharing of information about the immune system. Putative menstrual synchronization within social groups of women and putative acceleration of the menstrual cycle caused by men's odors may suggest the existence of human pheromone systems, but evidence in both cases is still inconclusive.
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References
Albone ES, Shirley SG (1984) Mammalian semiochemistry: the investigation of chemical signals between mammals. Wiley, New York
Arden M, Dye L (1998) The assessment of menstrual synchrony. J Comp Psychol 112:323–324
Bean NJ (1982) Modulation of agonistic behavior by the dual olfactory system in male mice. Physiol Behav 29:433–437
Beauchamp GK, Doty RL, Moulton DG, Mugford RA (1976) The pheromone concept in mammalian chemical communication: a brief critique. In: Doty RL (ed) Mammalian olfaction, reproductive processes and behaviours. Academic, New York, pp 143–160
Beauchamp GK, Wysocki CJ, Wellington JL (1985) Extinction of response to urine odor as a consequence of vomeronasal organ removal in male guinea pigs. Behav Neurosci 99:950–955
Beer AE, Semprini AE, Zhu XY, Quebbeman JF (1985) Pregnancy outcome in human couples with recurrent spontaneous abortions: HLA antigen profiles, HLA antigen sharing, female serum MLR blocking factors, and paternal leukocyte immunization. Exp Clin Immunogenet 2:137–153
Benton D (1982) The influence of androstenol—a putative human pheromone—on mood throughout the menstrual cycle. Bio Psychol 15:249–256
Benton D, Wastell V (1986) Effects of androstenol on human sexual arousal. Bio Psychol 22:141–147
Berliner DL, Jennings-White C, Lavker RM (1991) The human skin: fragrances and pheromones. J Steroid Biochem Mol Biol 39:671–679
Bhatnagar KP, Smith TD (2001) The human vomeronasal organ. III. Postnatal development from infancy to the ninth decade. J Anat 199:289–302
Black S, Biron C (1982) Androstenol as a human pheromone: no effect on perceived attractiveness. Behav Neural Biol 34:326–330
Brody B (1975) The sexual significance of the axillae. Psychiatry 38:278–280
Cooper WE, Burghardt GM (1990) Vomerolfaction and vomodor. J Chem Ecol 16:103–105
Cowley JJ, Brooksbank BWL (1991) Human exposure to putative pheromones and changes in aspects of social behaviour. J Steroid Biochem Mol Biol 39:647–659
Cowley JJ, Johnson AL, Brooksbank BWL (1977) The effect of two odorous compounds on performance in an assessment-of-people test. Psychoneuroendocrinology 2:159–172
Cutler WB, Garcia CR, Krieger AM (1980) Sporadic sexual behavior and menstrual cycle length in women. Horm Behav 14:163–172
Cutler WB, Preti G, Krieger A (1986) Human axillary secretions influence women's menstrual cycles: the role of donor extract from men. Horm Behav 20:463–473
Cutler WB, Friedmann E, McCoy NL (1998) Pheromonal influences on the sociosexual behavior of men. Arch Sex Behav 27:1–13
Dorries KM, Regan EA, Halpern BP (1997) Sensitivity and behavioral responses to the pheromone androstenone are not mediated by the vomeronasal organ in pigs. Brain Behav Evol 49:53–62
Doty RL, Orndorff MM, Leyden J, Kligman A (1978) Communication of gender from human axillary odors: relationship to perceived intensity and hedonicity. Behav Biol 23:373–380
Doty RL, Green PA, Ram C, Yankell SL (1982) Communication of gender from human breath odors: relationship between perceived intensity and pleasantness. Horm Behav 16:13–22
Dunbar RIM (1980) Demographic and life history variables of a population of gelada baboons (Theropithecus gelada). J Anim Ecol 49:485–506
Fernandez-Fewell GD, Meredith M (1995) Facilitation of mating behavior in male hamsters by LHRH and AcLHRH: interaction with the vomeronasal system. Physiol Behav 57:213–221
Filsinger EE, Braun JJ, Monte WC, Linder DE (1984) Human (Homo sapiens) response to the pig (Sus scrofa) sex pheromone 5-alpha-androst-16-en-3-one. J Comp Psychol 98:219–222
Filsinger EE, Braun JJ, Monte WC (1985) An examination of the effects of putative pheromones on human judgments. Ethol Sociobiol 6:227–236
Filsinger EE, Braun JJ, Monte WC (1990) Sex differences in response to the odor of alpha androstenone. Percept Mot Skills 70:216–218
French JA, Stribley JA (1987) Synchronization of ovarian cycles within and between social groups in golden lion tamarins (Leontopithecus rosalia). Am J Primatol 12:469–478
Garcia-Velasco J, Mondragon M (1991) The incidence of the vomeronasal organ in 1000 human subjects and its possible clinical significance. J Steroid Biochem Mol Biol 39:561–563
Gartska WR, Crews D (1986) Pheromones and reproduction in garter snakes. In: Duvall D (ed) Chemical signals in vertebrates 4. Plenum, New York, pp 243–260
Gorman ML, Ndwell DB, Smith RM (1974) An analysis of the contents of the anal scent pockets of Herpestes auropunctatus (Carnivora: Viverridae). J Zool 172:389–399
Gower DB, Ruparelia BA (1993) Olfaction in humans with special reference to odorous 16-androstenes: their occurrence, perception and possible social, psychological and sexual impact. J Endocrinol 137:167–187
Gower DB, Nixon A, Mallet AI (1988) The significance of odorous steroids in axillary odour. In: Van Toller S, Dodd GH (eds) Perfumery: the psychology and biology of fragrance. Chapman & Hall, London, pp 47–76
Gower DB, Holland KT, Mallet AI, Rennie PJ, Watkins WJ (1994) Comparison of 16-androstene steroid concentrations in sterile apocrine sweat and axillary secretions: interconversions of 16-androstenes by the axillary microflora and a mechanism for axillary odour production in man? J Steroid Biochem Mol Biol 48:409–418
Grosser BI, Monti-Bloch L, Jennings-White C, Berliner DL (2000) Behavioral and electrophysiological effects of androstadienone, a human pheromone. Psychoneuroendocrinology 25:289–299
Gustavson AR, Dawson ME, Bonett DG (1987) Androstenol, a putative human pheromone, affects human (Homo sapiens) male choice performance. J Comp Psychol 101:210–212
Handelmann G, Ravizza R, Ray WJ (1980) Social dominance determines estrous entrainment among female hamsters. Horm Behav 14:107–115
Howard JC (1977) H-2 and mating preferences. Nature 266:406–408
Hudson R, Distel H (1984) Nipple-search pheromone in rabbits: dependence on season and reproductive state. J Comp Physiol A 157:599–605
Huggins GR, Preti G (1981) Vaginal odors and secretions. Clin Obstet Gynecol 24:355–377
Immerman RS, Mackey WC (1997) A biocultural analysis of circumcision. Soc Biol 44:265–275
Jackman PJH, Noble WC (1983) Normal axillary skin microflora in various populations. Clin Exp Dermatol 8:259–268
Jacob S, McClintock MK (2000) Psychological state and mood effects of steroidal chemosignals in women and men. Horm Behav 37:57–78
Jacob S, Hayreh DJS, McClintock M (2001a) Context-dependent effects of steroid chemosignals on human physiology and mood. Physiol Behav 74:15–27
Jacob S, Kinnunen L, Metz J, Cooper M, McClintock MK (2001b) Sustained human chemosignal unconsciously alters brain function. Neuroreport 12:2391–2394
Jacob S, Garcia S, Hayreh D, McClintock M (2002) Psychological effects of musky compounds: comparison of androstadienone with androstenol and muscone. Horm Behav 42:274–283
Jesel L, Aron C (1976) The role of pheromones in the regulation of estrous cycle duration in the guinea pig. Neuroendocrinology 20:97–109
Jolly A (1967) Breeding synchrony in wild Lemur catta. In: Altmann SA (ed) Social communication among primates. Chicago University Press, Chicago, pp 3–14
Jordan WC, Bruford MW (1998) New perspectives on mate choice and the MHC. Heredity 81:239–245
Karlson P, Luscher M (1959) 'Pheromones': a new term for a class of biologically active substances. Nature 183:55–56
Kirk-Smith M, Booth DA (1980) Effects of androstenone on choice of location in others' presence. In: van der Starre H (ed) Olfaction and taste 7. IRL, London, pp 397–400
Kodis M, Moran D, Houy D (1998) Love scents. Dutton, New York
Kouro-Mehr H, Pintchovski S, Melnyk J, Chen YJ, Friedman C, Trask B, Shizuya H (2001) Chem Senses 26:1167–1174
Kummer H (1986) Social organization of hamadryas baboons. Chicago University Press, Chicago
Labows JN Jr (1988) Odor detection, generation and etiology in the axilla. In: Felgen C, Laden K (eds) Antiperspirants and deodorants. Dekker, New York
Lepri JJ, Wysocki CJ, Vandenbergh JG (1985) Mouse vomeronasal organ: effects on pheromone production and maternal behavior. Physiol Behav 35:809–814
Little BB, Guzick DS, Malina RM, Rocha Ferreira MD (1989) Environmental influences cause menstrual synchrony, not pheromones. Am J Hum Biol 1:53–57
Maiworm RE, Langthaler WU (1992) Influence of androstenol and androsterone on the evaluation of men of varying attractiveness levels. In: Doty RL, Muller-Schwarze D (eds) Chemical signals in vertebrates. VI. Plenum, New York, pp 575–579
Maruniak JA, Wysocki CJ, Taylor JA (1986) Mediation of male mouse urine marking and aggression by the vomeronasal organ. Physiol Behav 37:655–657
McClintock MK (1971) Menstrual synchrony and suppression. Nature 229:244–245
McClintock MK (1978) Estrous synchrony and its mediation by airborne chemical communication (Rattus norvegicus). Horm Behav 10:264–276
McClintock MK (1983) Pheromonal regulation of the ovarian cycle: enhancement, suppression, and synchrony. In: Vandenbergh JG (ed) Pheromones and reproduction in mammals. Academic, New York, pp 113–149
McClintock MK (1984) Estrous synchrony: modulation of ovarian cycle length by female pheromones. Physiol Behav 32:701–705
McCoy NL, Pitino L (2002) Pheromonal influences on sociosexual behavior in young women. Physiol Behav 75:367–375
McCullough PA, Owen JW, Pollak EI (1981) Does androstenol affect emotion? Ethol Sociobiol 2:85–88
Melrose DR, Patterson RLS, Reed HCB (1968) Improvements relating to artificial insemination of pigs. British patent no. 35201
Meredith M (1994) Chronic recording of vomeronasal pump activation in awake behaving hamsters. Physiol Behav 56:345–354
Michael RP (1972) Fragrance blends based on the fatty acids and their employment in pharmaceutical products. French patent no. 2124399
Michael RP, Zumpe D (1982) Influence of olfactory signals on the reproductive behaviour of social groups of rhesus monkeys (Macaca mulatta). J Endocrinol 95:189–205
Michael RP, Keverne EB, Bonsall RW (1971) Pheromones: isolation of male sex attractants from a female primate. Science 172:964–966
Michael RP, Bonsall RW, Kutner M (1975) Volatile fatty acids, "copulins", in human vaginal secretions. Psychoneuroendocrinology 1:153–163
Milinski M, Wedekind C (2001) Evidence for MHC-correlated perfume preferences in humans. Behav Ecol 12:140–149
Moeller JF, Meredith M (1998) Increase in gonadotropin-releasing hormone (GnRH) levels in CSF after stimulation of the nervus terminalis in Atlantic stingray, Dasyatis sabina. Brain Res 806:104–107
Montagna W (1964) Histology and histochemistry of human skin. XXIV. Further observations on the axillary organ. J Invest Dermatol 42:119–129
Monti-Bloch L, Grosser BI (1991) Effect of putative pheromones on the electrical activity of the human vomeronasal organ and olfactory epithelium. J Steroid Biochem Mol Biol 39:573–582
Monti-Bloch L, Jennings-White C, Dolberg DS, Berliner DL (1994) The human vomeronasal system. Psychoneuroendocrinology 19:673–686
Monti-Bloch L, Diaz-Sanchez V, Jennings-White C, Berliner DL (1998) Modulation of serum testosterone and autonomic function through stimulation of the male human vomeronasal organ (VMO) with pregna-4,20-diene-3,6-dione. J Steroid Biochem Mol Biol 65:237–242
Moran DT, Jafek BW, Rowley JC III (1991) The vomeronasal (Jacobson's) organ in man: ultrastructure and frequency of occurrence. J Steroid Biochem Mol Biol 39:545–552
Ober C, Elias S, O'Brien E, Kostyu DD, Hauck WW, Bombard A (1988) HLA sharing and fertility in Hutterite couples: evidence for prenatal selection against compatible fetuses. Am J Reprod Immunol Microbiol 18:111–115
Ober C, Weitkamp LR, Cox N, Dytch H, Elias S (1997) HLA and mate choice in humans. Am J Hum Genet 61:497–504
Pawlowski B (1999) Loss of oestrus and concealed ovulation in human evolution: the case against the sexual-selection hypothesis. Curr Anthropol 40:257–275
Penn D, Potts W (1998) How do major histocompatibility complex genes influence odor and mating preferences? Adv Immunol 69:411–436
Porter RH, Weinberg J (1999) Unique salience of maternal breast odors for newborn infants. Neurosci Biobehav Rev 23:439–449
Preti G, Cutler WB, Garcia CT (1986) Human axillary secretions influence women's menstrual cycles: the role of donor extract of females. Horm Behav 20:474–482
Reynolds J, Keverne EB (1979) The accessory olfactory system and its role in the pheromonally mediated suppression of oestrus in grouped mice. J Reprod Fertil 57:31–35
Reznikoff-Etievant MF, Bonneau JC, Alcalay D, Cavelier B, Toure C, Lobet R, Netter A (1991) HLA antigen-sharing in couple with repeated spontaneous abortions and the birthweight of babies in successful pregnancies. Am J Reprod Immunol 25:25–27
Rood JP (1975) Population dynamics and food habits of the banded mongoose. East Afr Wildl J 13:89–111
Rood JP (1980) Mating relationships and breeding suppression in the dwarf mongoose. Anim Behav 28:143–150
Rowell TE, Richards SM (1979) Reproductive strategies of some African monkeys. J Mammal 60:58–69
Russell MJ (1976) Human olfactory communication. Nature 260:520–522
Russell MJ, Switz GM, Thompson K (1980) Olfactory influences on the human menstrual cycle. Pharmacol Biochem Behav 13:737–738
Schank JC (2001) Menstrual cycle synchrony: problems and new directions for research. J Comp Psychol 115:3–15
Schleidt M, Hold B (1982) Human odour and identity. In: Breipohl W (ed) Olfaction and endocrine regulation. Information Retrieval, Oxford, pp 181–194
Schleidt M, Hold B, Attili G (1981) A cross-cultural study on the attitude towards personal odors. J Chem Ecol 7:19–31
Shinohara K, Morofushi M, Funabashi T, Kimura F (2001) Axillary pheromones modulate pulsatile LH secretion in humans. Neuroreport 12:893–895
Signoret JP (1991) Sexual pheromones in the domestic sheep: importance and limits in the regulation of reproductive physiology. J Steroid Biochem Mol Biol 39:639–645
Smith AB III, Belcher AM, Epple G, Jurs PC, Lavine B (1985) Computerized pattern recognition: a new technique for the analysis of chemical communication. Science 228:175
Sobel N, Prabhakaran V, Hartley CA, Desmond JE, Glover GH, Sullivan EV, Gabrieli JDE (1999) Blind smell: brain activation induced by an undetected airborne chemical. Brain 122:209–217
Stensaas LJ, Lakver RM, Monti-Bloch L, Grosser BI, Berliner DL (1991) Ultrastructure of the human vomeronasal organ. J Steroid Biochem Mol Biol 39:553–560
Stern K, McClintock MK (1998) Regulation of ovulation by human pheromones. Nature 392:177–179
Veith JL, Buck M, Getzlaf S, Van Dalfesen P, Slade S (1983) Exposure to men influences the occurrence of ovulation in women. Psychol Behav 31:313
Wallis J (1985) Synchrony of estrous swelling in captive group-living chimpanzees (Pan troglodytes). Int J Primatol 6:335–350
Wedekind C, Furi S (1997) Body odour preferences in men and women: do they aim for specific MHC combinations or simply heterozygosity? Proc R Soc Lond Biol 264:1471–1479
Wedekind C, Seebeck T, Bettens F, Paepke AJ (1995) MHC-dependent mate preferences in humans. Proc R Soc Lond Biol 260:245–249
Weetman AP (1999) The immunology of pregnancy. Thyroid 9:643–646
Weller A, Weller L (1992) Menstrual synchrony in female couples. Psychoneuroendocrinology 17:171–177
Weller A, Weller L (1993a) Menstrual synchrony between mothers and daughters and between roommates. Physiol Behav 53:943–949
Weller L, Weller A (1993b) Multiple influences on menstrual synchrony: kibbutz roommates, their best friends, and their mothers. Am J Hum Biol 5:173–179
Weller A, Weller L (1995a) The impact of social interaction factors on menstrual synchrony in the workplace. Psychoneuroendocrinology 20:21–31
Weller A, Weller L (1995b) Examination of menstrual synchrony among women basketball players. Psychoneuroendocrinology 20:613–622
Weller A, Weller L (1997) Menstrual synchrony under optimal conditions: Bedouin families. J Comp Psychol 111:143–151
Weller L, Weller A, Avinir O (1995) Menstrual synchrony: only in roommates who are close friends? Physiol Behav 58:883–889
Weller L, Weller A, Koresh KH, ben Shoshan R (1999a) Menstrual synchrony in a sample of working women. Psychoneuroendocrinology 24:449–459
Weller L, Weller A, Roizman S (1999b) Human menstrual synchrony in families and among close friends: examining the importance of mutual exposure. J Comp Psychol 113:261–268
Wilson HC (1992) A critical review of menstrual synchrony research. Psychoneuroendocrinology 17:565–591
Wilson HC, Kiefhaber SH, Gravel V (1991) Two studies of menstrual synchrony: negative results. Psychoneuroendocrinology 16:353–360
Wirsig CR, Leonard CM (1985) Terminal nerve damage affects hamster mating behavior. Chem Senses 10:423
Witt M, Georgiewa B, Knecht M, Hummel T (2002) On the chemosensory nature of the vomeronasal epithelium in adult humans. Histochem Cell Biol 117:493–509
Wohrmann-Repenning A (2000) The human vomeronasal organ and pheromonal communication: facts and fantasy. Z Saugetierkd 65:380–382
Wysocki CJ, Lepri JJ (1991) Consequences of removing the vomeronasal organ. J Steroid Biochem Mol Biol 39:661–669
Wysocki CJ, Meredith M (1987) The vomeronasal system. In: Finger TE, Silver WL (eds) Neurobiology of taste and smell. Wiley, New York, pp 125–150
Wysocki CJ, Preti G (1998) Pheromonal influences. Arch Sex Behav 27:627–629
Wysocki CJ, Preti G (2000) Human body odors and their perception. Jpn J Taste Smell Res 7:19–42
Wysocki CJ, Katz Y, Bernhard R (1983) The male vomeronasal organ mediates female-induced testosterone surges. Biol Reprod 28:917–922
Acknowledgements
I would like to gratefully acknowledge the following individuals, who spoke to me about their research and gave perspective to this review: David Berliner, Michael Kirk-Smith, Martha McClintock, Richard Michael, George Preti, Lisa Rapaport, Charles Wysocki, and Doria Zumpe. Thanks also go to Andrew Brittain, Sue Davie, David Horgen, and Julian Talbot for their help and ideas.
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Hays, W.S.T. Human pheromones: have they been demonstrated?. Behav Ecol Sociobiol 54, 89–97 (2003). https://doi.org/10.1007/s00265-003-0613-4
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DOI: https://doi.org/10.1007/s00265-003-0613-4