Abstract
In modern times scurvy is a rarely encountered disease caused by ascorbic acid (vitamin C) deficiency. However, sporadic cases of scurvy persist, particularly within the pediatric population. Recent individual case reports highlight an increased incidence of scurvy among patients with autism or developmental delay, with isolated case reports detailing the magnetic resonance imaging (MRI) findings of scurvy in these pediatric populations. We present the MRI findings of scurvy in four patients with autism or developmental delay, and review the literature on MRI findings in pediatric patients with scurvy. Despite its rarity, the radiologist must consider scurvy in a pediatric patient with a restricted diet presenting with arthralgia or myalgia.
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References
Adams JB, Audhya T, McDonough-Means S, Rubin RA, Quig D, Geis E, et al. Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity. Nutr Metab. 2011;8(1):34.
Arnold GL, Hyman SL, Mooney RA, Kirby RS. Plasma amino acids profiles in children with autism: potential risk of nutritional deficiencies. J Autism Dev Disord. 2003;33(4):449–54.
Rajakumar K. Infantile scurvy: a historical perspective. Pediatrics. 2001;108(4):E76.
Noble JM, Mandel A, Patterson MC. Scurvy and rickets masked by chronic neurologic illness: revisiting “psychologic malnutrition”. Pediatrics. 2007;119(3):e783–90.
Weinstein M, Babyn P, Zlotkin S. An orange a day keeps the doctor away: scurvy in the year 2000. Pediatrics. 2001;108(3):E55.
Fain O. Musculoskeletal manifestations of scurvy. Joint Bone Spine. 2005;72(2):124–8.
Duggan CP, Westra SJ, Rosenberg AE. Case records of the Massachusetts General Hospital. Case 23–2007. A 9-year-old boy with bone pain, rash, and gingival hypertrophy. N Engl J Med. 2007;357(4):392–400.
Yochum TR, Rowe LJ. Yochum and Rowe’s essentials of skeletal radiology. 3rd ed. Philadelphia: Lippincott/Williams & Wilkins; 2005.
Choi SW, Park SW, Kwon YS, Oh IS, Lim MK, Kim WH, et al. MR imaging in a child with scurvy: a case report. Korean J Radiol. 2007;8(5):443–7.
Niwa T, Aida N, Tanaka Y, Tanaka M, Shiomi M, Machida J. Scurvy in a child with autism: magnetic resonance imaging and pathological findings. J Pediatr Hematol Oncol. 2012;34(6):484–7.
Kumar V, Abbas AK, Fausto N, Robbins SL, Cotran RS. Robbins and Cotran pathologic basis of disease. 7th ed. Philadelphia: Elsevier Saunders; 2005.
Fahey FH, Treves ST, Adelstein SJ. Minimizing and communicating radiation risk in pediatric nuclear medicine. J Nucl Med. 2011;52(8):1240–51.
Karthiga S, Dubey S, Garber S, Watts R. Scurvy: MRI appearances. Rheumatology. 2008;47(7):1109.
Cole JA, Warthan MM, Hirano SA, Gowen Jr CW, Williams JV. Scurvy in a 10-year-old boy. Pediatr Dermatol. 2011;28(4):444–6.
Brennan CM, Atkins KA, Druzgal CH, Gaskin CM. Magnetic resonance imaging appearance of scurvy with gelatinous bone marrow transformation. Skeletal Radiol. 2012;41(3):357–60.
Gongidi P, Johnson C, Dinan D. Scurvy in an autistic child: MRI findings. Pediatr Radiol. 2013;43(10):1396–9.
Harknett KM, Hussain SK, Rogers MK, Patel NC. Scurvy mimicking osteomyelitis: case report and review of the literature. Clin Pediatr (Phila). 2013; doi: 10.1177/0009922813506609
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Gulko, E., Collins, L.K., Murphy, R.C. et al. MRI findings in pediatric patients with scurvy. Skeletal Radiol 44, 291–297 (2015). https://doi.org/10.1007/s00256-014-1962-y
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DOI: https://doi.org/10.1007/s00256-014-1962-y