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Reproducibility of Oxygen Saturation Monitoring During Six-Minute Walk Test and Exercise Stress Test in Patients with Pulmonary Arteriovenous Malformations Associated With Hereditary Hemorrhagic Telangiectasia

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Abstract

Patients with pulmonary arteriovenous malformations (PAVMs) are at risk for multiple complications and require close follow-up. We investigated the reproducibility of the 6-minute walk test (6MWT) and exercise stress test (EST) for the evaluation of low oxygen saturation in patients with PAVMs. Twenty-two patients with PAVMs, most of whom had hereditary hemorrhagic telangiectasia (HHT), participated in a Human Investigations Committee-approved protocol. Patients ranged from 9 to 74 years of age (mean 28) and had a broad spectrum of anatomic subtypes of PAVMs, including focal and diffuse. Standard 6MWT and cycle ergometry EST were both performed twice with adequate rest between tests. Heart rate (HR) and oxygen saturation were measured at the beginning and end of each test. Distance walked and maximum resistance was also recorded. The intraclass correlation coefficients (ri) at the end of 6MWT were as follows: HR (ri = 0.940; 95% confidence interval [CI] 0.863–0.975), oxygen saturation (ri = 0.973; 95% CI 0.933–0.989), and distance (ri = 0.942; 95% CI 0.867–0.975). The ris at the end of EST were as follows: HR (ri = 0.941; 95% CI 0.865–0.975), oxygen saturation (ri = 0.993; 95% CI 0.982–0.997), and maximum resistance (ri = 0.941; 95% CI 0.864–0.975). 6MWT and EST were reproducible measures of exercise capacity and oxygen saturation and are potential adjunct tests in the follow-up assessment for patients with PAVMs.

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Acknowledgments

This study was supported in part by the Nicole McConnell Foundation and the Josephine Lawrence Hopkins Foundation. This publication was made possible by CTSA Grant Number UL1 RR024139 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research. The contents herein are solely the responsibility of the authors and do not necessarily represent the official view of NCRR or NIH. Information on Re-engineering the Clinical Research Enterprise can be obtained from the NIH website.

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Correspondence to Walter Li.

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Li, W., Niu, B., Henderson, K. et al. Reproducibility of Oxygen Saturation Monitoring During Six-Minute Walk Test and Exercise Stress Test in Patients with Pulmonary Arteriovenous Malformations Associated With Hereditary Hemorrhagic Telangiectasia. Pediatr Cardiol 32, 590–594 (2011). https://doi.org/10.1007/s00246-011-9917-8

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