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Analysis of Ventricular Hypertrabeculation and Noncompaction Using Genetically Engineered Mouse Models

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Abstract

Ventricular trabeculation and compaction are two of the many essential steps for generating a functionally competent ventricular wall. A significant reduction in trabeculation is usually associated with ventricular compact zone deficiencies (hypoplastic wall), which commonly lead to embryonic heart failure and early embryonic lethality. In contrast, hypertrabeculation and lack of ventricular wall compaction (noncompaction) are closely related defects in cardiac embryogenesis associated with left ventricular noncompaction, a genetically heterogeneous disorder. Here we summarize our recent findings through the analyses of several genetically engineered mouse models that have defects in cardiac trabeculation and compaction. Our data indicate that cellular growth and differentiation signaling pathways are keys in these ventricular morphogenetic events.

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Acknowledgment

This study was supported in part by National Institutes of Health Grants HL81092 (W.S.), HL70259 (W.S.), and HL85098 (W.S., M.P.).

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Authors and Affiliations

  1. Riley Heart Research Center, Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA

    Hanying Chen, Wenjun Zhang, Deqiang Li, Tim M. Cordes, R. Mark Payne & Weinian Shou

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  1. Hanying Chen
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  2. Wenjun Zhang
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  3. Deqiang Li
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  4. Tim M. Cordes
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  6. Weinian Shou
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Correspondence to Weinian Shou.

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Chen, H., Zhang, W., Li, D. et al. Analysis of Ventricular Hypertrabeculation and Noncompaction Using Genetically Engineered Mouse Models. Pediatr Cardiol 30, 626–634 (2009). https://doi.org/10.1007/s00246-009-9406-5

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  • DOI: https://doi.org/10.1007/s00246-009-9406-5

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