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Positive coping style reduction in elderly end-stage renal disease patients: mediating role of white matter mean diffusivity

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Abstract

Purpose

The aim of this study was to explore elderly patients with end-stage renal disease (ESRD) white matter changes, the relationship between white matter (WM) abnormalities and emotional regulation strategies, coping styles in elderly ESRD patients.

Methods

Twenty-eight elderly ESRD patients and twenty-eight sex and age matched healthy controls (HC) were included in this study. Tract-based spatial statistic (TBSS) was used to investigate the microstructural changes of WM. Two questionnaires were used to measure emotional regulation strategies and coping styles.

Results

Neuroimaging analysis showed that the damage of WM structure was widespread in elderly ESRD patients. Psychological test results showed that there were differences in emotional regulation strategies and coping styles between elderly ESRD patients and HC. Furthermore, mediating analysis showed that the mean diffusivity (MD) of the significantly different brain regions played a complete mediating role between group and positive coping style.

Conclusion

These results suggest that the integrity of WM, emotional regulation strategies and coping styles play an important role in ESRD patients. Our findings provide evidence that positive coping style may be fully mediated by MD. These results may help us develop new ways to treat and prevent physical and psychological problems in elderly ESRD hemodialysis patients.

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Data availability

Data and material are available with the corresponding author.

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Funding

This study was supported by National Natural Science Foundation of China (81871344); Natural Science Foundation of Jiangsu Province (BK20191369); Qing Lan Project of the Higher Educations of Jiangsu Province; Open Research Fund of the Jiangsu Key Laboratory of Mental Health and Cognitive Science(19MHCSKF01).

Author information

Author notes

  1. Meiling Gu and Dongsheng Jin contributed equally to this work.

Authors and Affiliations

  1. Department of Psychology, Nanjing Normal University, Nanjing, Jiangsu, China

    Meiling Gu, Yuan Zhong, Fupei Tong & Jianze Wu

  2. Department of Radiology, Geriatric Hospital, Nanjing Medical University, Nanjing, 210024, Jiangsu, China

    Dongsheng Jin, Huixin Zhang & Yane Zhao

  3. Department of Nephrology, Geriatric Hospital, Nanjing Medical University, 65 Jiangsu Road, Nanjing, 210024, Jiangsu, China

    Yan Chen

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  1. Meiling Gu
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  2. Dongsheng Jin
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  3. Yuan Zhong
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  4. Huixin Zhang
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  5. Fupei Tong
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  6. Jianze Wu
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Contributions

Yan Chen and Yane Zhao conceived and designed the experiment; Meiling Gu and Dongsheng Jin analyzed the data; Meiling Gu, Dongsheng Jin, Yan Chen and Yane Zhao interpreted the results and wrote the paper; Meiling Gu, Dongsheng Jin, Yuan Zhong, Huixin Zhang, Fupei Tong, Jianze Wu, Yan Chen and Yane Zhao revised the paper.

Corresponding authors

Correspondence to Yan Chen or Yane Zhao.

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Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the ethics committee at the Nanjing Normal University, China (Ethical code: NNU202106033).

Informed consent

Informed consent was obtained from all individual participants included in the study.

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The authors have no relevant financial or non-financial interests to disclose.

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Yan Chen and Yane Zhao are Corresponding author.

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Gu, M., Jin, D., Zhong, Y. et al. Positive coping style reduction in elderly end-stage renal disease patients: mediating role of white matter mean diffusivity. Neuroradiology 64, 817–824 (2022). https://doi.org/10.1007/s00234-022-02904-1

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