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Gradual withdrawal from benzodiazepines in residents of homes for the elderly: experience and suggestions for future research

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Abstract

Objective

A randomised, controlled clinical trial was performed to study the long-term effect of gradual withdrawal from benzodiazepines on the daily functioning of residents of homes for the elderly. The planned sample size was not achieved due to recruitment and follow-up problems.

Results

The results in this small sample nevertheless suggest that gradual withdrawal from benzodiazepines is possible in residents of homes for the elderly, and that it can have a positive effect on their daily functioning. No major withdrawal symptoms were observed, although there was a decrease in sleep quality during withdrawal.

Conclusion

The findings are promising for further research, but researchers should anticipate the problems inherent in executing a trial with institutionalised elderly subjects.

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References

  1. Allgulander C, Ljungberg L, Fisher LD (1987) Long-term prognosis in addiction on sedative and hypnotic drugs analyzed with the Cox Regression Model. Acta Psychiatr Scand 75: 521–531

    Article  PubMed  CAS  Google Scholar 

  2. Greenblatt DJ, Allen AD (1978) Toxicity of nitrazepam in the elderly: a report from the Boston collaborative drug surveillance program. Br J Clin Pharmacol 5: 407–13

    PubMed  CAS  Google Scholar 

  3. Greenblatt DJ, Divoll M, Harmatz JS, MacLaughlin DS, Shader RJ (1981) Kinetics and clinical effects of flurazepam in young and elderly noninsomniacs. Clin Pharmacol Ther 30: 475–186

    PubMed  CAS  Google Scholar 

  4. Greenblatt J, Sellers EM, Shader RI (1982) Drug disposition in old-age. N Engl J Med 306: 1081–1088

    PubMed  CAS  Google Scholar 

  5. Greenblatt DJ, Harmatz JS, Shapiro L, Engelhardt N, Gouthro TA, Shader RJ (1991) Sensitivity to triazolam in the elderly. N Engl J Med 324: 1691–1698

    PubMed  CAS  Google Scholar 

  6. Nolan L, O’Malley K (1988) Patients, prescribing and benzodiazepines. Eur J Clin Pharmacol 35: 225–229

    Article  PubMed  CAS  Google Scholar 

  7. Giblin MJ, Clift AD (1983) Sleep without drugs. J Roy Coll Gen Pract 33: 628–633

    CAS  Google Scholar 

  8. Jones D (1990) Weaning elderly patients off psychotropic drugs in general practice: a randomised controlled trial. Health Trends 4: 164–166

    Google Scholar 

  9. Larson EB, Kukull WA, Buchner D, Reifler BV (1987) Adverse drug reactions associated with global cognitive impairment in elderly persons. Ann Int Med 107: 169–173

    PubMed  CAS  Google Scholar 

  10. Gilbert A, Owen N, Innes JM, Sansom L (1993) Trial of an intervention to reduce chronic benzodiazepine use among residents of aged-care accommodation. Aust NZ J Med 23: 343–347

    CAS  Google Scholar 

  11. Salzman C, Fisher J, Nobel K, Glassman R, Wolfson A, Kelley M (1992) Cognitive improvement following benzodiazepine discontinuation in elderly nursing home residents. Int J Ger Psychiatry 7: 89–93

    Article  Google Scholar 

  12. National Health and Medical Research Council (1992) Guidelines for the prevention and management of benzodiazepine dependence. Report of the Health Care Committee Expert Advisory Panel on Alcohol and Drug Use. Australia

  13. Tyrer P, Murphy S, Riley P (1990) The benzodiazepine withdrawal symptom questionnaire. J Affective Disorders 19: 53–61

    Article  CAS  Google Scholar 

  14. Mulder WREH, van der Meulen H (1980) Measurement of subjective sleep quality. Internal report, Department of Biological Psychiatry, Psychiatric University Clinic, Groningen

    Google Scholar 

  15. Gorissen JP (1986) Een differentiële beschrijving van de SDAT-patiënt met twee gedragsobservatieschalen: de BOP en de GOS-G. [A differential description of the SDAT patient with two behaviour observation scales: the BOP and the GOS-G] T Gerontologie en Geriatrie 17: 17–24

    CAS  Google Scholar 

  16. Tata PR, Rollings J, Collins M, Pickering A, Jacobson RR (1994) Lack of cognitive recovery following withdrawal from long-term benzodiazepine use. Psychol Med 24: 203–213

    Article  PubMed  CAS  Google Scholar 

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Habraken, H., Soenen, K., Blondeel, L. et al. Gradual withdrawal from benzodiazepines in residents of homes for the elderly: experience and suggestions for future research. Eur J Clin Pharmacol 51, 355–358 (1997). https://doi.org/10.1007/s002280050213

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  • DOI: https://doi.org/10.1007/s002280050213

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