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Tramadol concentrations in blood and in cerebrospinal fluid in a neonate

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Abstract

Based on blood and cerebrospinal fluid samples collected in a full-term neonate, the penetration of tramadol in the central nervous system is described. Following intravenous administration of tramadol, a lag time of about 4 h was observed until full blood–brain equilibration was achieved. This pharmacokinetic observation is in line with a recent pharmacodynamic evaluation of the central opioid effects of tramadol in adults.

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Acknowledgements

The clinical research of Karel Allegaert is supported by the Fund for Scientific Research, Flanders (Belgium) (F.W.O. Vlaanderen) by a Clinical Doctoral Grant (A 6/5—KV—G 1).

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Authors and Affiliations

  1. Department of Paediatrics, University Hospital, Gasthuisberg, Leuven, Belgium

    K Allegaert & H Devlieger

  2. Center for Clinical Pharmacology, University Hospital, Gasthuisberg, Leuven, Belgium

    J de Hoon & R Verbesselt

  3. Department of Paediatric Surgery, Erasmus Medical Centre, Sophia’s Children, Rotterdam, The Netherlands

    K Allegaert & D Tibboel

Authors
  1. K Allegaert
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  2. J de Hoon
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  3. R Verbesselt
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  4. H Devlieger
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  5. D Tibboel
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Correspondence to K Allegaert.

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Allegaert, K., de Hoon, J., Verbesselt, R. et al. Tramadol concentrations in blood and in cerebrospinal fluid in a neonate. Eur J Clin Pharmacol 60, 911–913 (2005). https://doi.org/10.1007/s00228-004-0872-7

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  • DOI: https://doi.org/10.1007/s00228-004-0872-7

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