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Differences in negative mood-induced smoking reinforcement due to distress tolerance, anxiety sensitivity, and depression history

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Abstract

Rationale

Negative mood increases smoking reinforcement and may do so to a greater degree in smokers vulnerable to negative mood dysregulation.

Methods

Adult smokers (N = 71) without current depression were randomly assigned to one of two smoking conditions (nicotine or denic cigarettes, presented blind) maintained across all sessions. Subjects completed one neutral mood session and four negative mood induction sessions. Negative mood inductions included one each of the following: 1) overnight smoking abstinence, 2) challenging computer task, 3) public speech preparation, 4) watching negative mood slides. In each session, subjects took 4 puffs on their assigned cigarette, rated it for “liking” (reward), and then smoked those cigarettes ad libitum (reinforcement) during continued mood induction. Affect was assessed intermittently before and after smoking. Differences in responses were examined as functions of self-reported history of major depression and levels of distress tolerance and anxiety sensitivity.

Results

Smoking reinforcement, but not reward or negative affect relief, was greater in all sessions in those with a history of depression and greater after overnight abstinence in those with lower distress tolerance. Reward and affect relief, but not reinforcement, were greater during speech preparation among those high in anxiety sensitivity.

Conclusions

Low distress tolerance may enhance acute smoking reinforcement due to abstinence, while depression history may broadly increase acute smoking reinforcement regardless of mood. Neither smoking reward nor affect help explain these individual differences in smoking reinforcement.

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Acknowledgments

This research was supported by NIDA Grants DA19478 and DA027449. The authors thank Amy Grottenthaler, Melissa Mercincavage, Roy Chengappa, and Carolyn Fonte for their assistance.

Disclosures

Dr. Perkins has consulted with GlaxoSmithKline on the development of smoking cessation medications. No other authors have any disclosures.

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Authors and Affiliations

  1. Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O’Hara Street, Pittsburgh, PA, 15213, USA

    Kenneth A. Perkins, Joshua L. Karelitz, Grace E. Giedgowd & Cynthia A. Conklin

  2. Department of Psychology, University of Pittsburgh, 3137 Sennott Square, Pittsburgh, PA, 15261, USA

    Michael A. Sayette

Authors
  1. Kenneth A. Perkins
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  2. Joshua L. Karelitz
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  3. Grace E. Giedgowd
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  4. Cynthia A. Conklin
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  5. Michael A. Sayette
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Corresponding author

Correspondence to Kenneth A. Perkins.

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Perkins, K.A., Karelitz, J.L., Giedgowd, G.E. et al. Differences in negative mood-induced smoking reinforcement due to distress tolerance, anxiety sensitivity, and depression history. Psychopharmacology 210, 25–34 (2010). https://doi.org/10.1007/s00213-010-1811-1

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  • DOI: https://doi.org/10.1007/s00213-010-1811-1

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