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Nicotine psychobiology: how chronic-dose prospective studies can illuminate some of the theoretical issues from acute-dose research

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Abstract

Rationale

To illustrate how prospective cigarette smoking research can illuminate some of the theoretical dilemmas about nicotine psychobiology from acute dose research.

Methods and results

When briefly deprived smokers are administered nicotine, they display a range of psychobiological ‘gains’, with improved cognitive performance, feelings of contentment, and reduced feelings of stress or depression. However, abstinence leads to decrements in all these functions. The balance between the deficits of nicotine deprivation and the gains of reinstatement has been debated for decades. Yet, it still remains controversial whether nicotine is psychobiologically beneficial, neutral or detrimental. Some illumination may be provided by prospective research. Taking up smoking during adolescence is often followed by increased feelings of stress and depression, whereas quitting is often associated with subsequent mood gains. Short-term prospective studies reveal that the essence of nicotine dependency is repetitive psychobiological vacillation. The mood gains of smoke inhalation represent the temporary reversal of abstinence effects, and the frequent experience of negative states in between cigarettes explains why smoking can increase psychobiological distress. This may also be linked with Diathesis–Stress models. If withdrawal symptoms reflect the exacerbation of natural predispositions, then ‘disadvantaged’ smokers will suffer the worst abstinence symptoms and develop the strongest nicotine dependency. This explanation contrasts with the self-medication model, which focuses on the immediate benefits of smoke inhalation, rather than the overall costs of nicotine use.

Conclusions

The frequent experience of negative psychological states in between cigarettes helps to explain why nicotine dependency is associated with a range of psychobiological problems.

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References

  • Adan A, Sanchez-Turet M (2000) Effects of smoking on diurnal variations of subjective activation and mood. Hum Psychopharmacol 15:287–294

    Article  PubMed  Google Scholar 

  • Adan A, Prat G, Sanchez-Turet M (2004) Effects of nicotine dependence on diurnal variations of subjective activation and mood. Addiction 99:1599–1607

    Article  PubMed  Google Scholar 

  • Alves G, Kurz M, Lie SA, Larsen JP (2005) Cigarette smoking in Parkinson’s disease: influence on disease progression. Mov Disord 19:1087–1092

    Article  Google Scholar 

  • Anda RF, Croft JB, Felitti VJ, Nordenberg D, Giles WH, Williamson DF, Giovino GA (1999) Adverse childhood experiences and smoking during adolescence and adulthood. JAMA 282:1652–1658

    Article  PubMed  CAS  Google Scholar 

  • Ashton H, Savage RD, Telford R, Thompson JW, Watson DW (1972) The effects of cigarette smoking on the response to stress in a driving simulator. Br J Pharmacol 45:546–556

    PubMed  CAS  Google Scholar 

  • Baker TB, Piper ME, McCarthy DE, Majeskie MR, Fiore MC (2004) Addiction motivation reformulated: an affective processing model of negative reinforcement. Psychol Rev 111:33–51

    Article  PubMed  Google Scholar 

  • Beckham JC, Kirby AC, Feldman ME, Hertzberg MA, Moore SD, Crawford AL, Davidson JRT, Fairbank JA (1997) Prevalence and correlates of heavy smoking in Vietnam veterans with chronic post-traumatic stress disorder. Addict Behav 22:637–647

    Article  PubMed  CAS  Google Scholar 

  • Beratis S, Katrinavou A, Gourzis P (2001) Factors affecting smoking in schizophrenia. Comp Psychiat 42:393–402

    Article  CAS  Google Scholar 

  • Boutrel B, Koob GF (2004) What keeps us awake: the neuropharmacology of stimulants and wakefulness-promoting medications. Sleep 27:1181–1194

    PubMed  Google Scholar 

  • Breslau N, Peterson EL, Schultz LR, Chilcoat HD, Andreski P (1998) Major depression and stages of smoking: a longitudinal investigation. Arch Gen Psychiatry 55:161–166

    Article  PubMed  CAS  Google Scholar 

  • Brown B (1973) Additional characteristic EEG differences between heavy smoker and non-smoker subjects. In: Dunn WL (ed) Smoking behaviors: motives and incentives. Washington, Winston & Sons

    Google Scholar 

  • Breslau N, Schultz LR, Johnson EO, Peterson EL, Davis GC (2005) Smoking and the risk of suicidal behavior: a prospective study of a community sample. Arch Gen Psychiatry 62:328–334

    Article  PubMed  Google Scholar 

  • Carey MP, Kalra DL, Carey KB, Halperin S, Richards CS (1993) Stress and unaided smoking cessation: a prospective investigation. J Consult Clin Psychol 61:831–838

    Article  PubMed  CAS  Google Scholar 

  • Chassin L, Presson CC, Sherman SJ, Kim K (2002) Long term psychological sequelae of smoking cessation and relapse. Health Psychol 21:438–443

    Article  PubMed  Google Scholar 

  • Choquette KA, Hesselbrock MN (1987) Effects of retesting with the Beck and Zung depression scales in alcoholics. Alcohol Alcohol 22:277–283

    PubMed  CAS  Google Scholar 

  • Cohen S, Lichtenstein E (1990) Perceived stress, quitting smoking, and smoking relapse. Health Psychol 9:466–478

    Article  PubMed  CAS  Google Scholar 

  • Combs DR, Advokat A (2000) Antipsychotic medication and smoking prevalence in hospitalised patients with chronic schizophrenia. Schizophrenia Res 46:129–137

    Article  CAS  Google Scholar 

  • Covey LS, Glassman AH, Stetner F (1990) Depression and depressive symptoms in smoking cessation. Compr Psychiatry 31:350–354

    Article  PubMed  CAS  Google Scholar 

  • Covey LS, Glassman AH, Stetner F (1997) Major depression following smoking cessation. Am J Psychiatry 154:263–265

    PubMed  CAS  Google Scholar 

  • Dinn WM, Aycicegi A, Harris CL (2004) Cigarette smoking in a student sample: neurocognitive and clinical correlates. Addict Behav 29:107–126

    Article  PubMed  Google Scholar 

  • Dudas MM, George TP (2005) Non-nicotine pharmacotherapies for nicotine dependence. Essent Psychopharmacol 6:158–172

    PubMed  Google Scholar 

  • Ernst M, Heishman SJ, Spurgeon L, London ED (2001) Smoking history and nicotine effects on cognitive performance. Neuropsychopharmacology 25:313–319

    Article  PubMed  CAS  Google Scholar 

  • Escobedo LG, Reddy M, Giovino GA (1998) The relationship between depressive symptoms and cigarette smoking in US adolescents. Addiction 93:433–440

    Article  PubMed  CAS  Google Scholar 

  • Fant RV, Schuh KJ, Stitzer ML (1995) Response to smoking as a function of prior smoking amounts. Psychopharmacology 119:385–390

    Article  PubMed  CAS  Google Scholar 

  • Fergusson DM, Goodwin RD, Horwood LJ (2003) Major depression and cigarette smoking: results of a 21-year longitudinal study. Psychol Med 33:1357–1367

    Article  PubMed  CAS  Google Scholar 

  • Foulds J (1994) Detrimental effects of nicotine on mood? Addiction 89:136–138

    Article  PubMed  CAS  Google Scholar 

  • Fratiglioni LI, Wang HX (2000) Smoking and Parkinson’s and Alzheimer’s disease: review of the epidemiological studies. Behav Brain Res 113:117–120

    Article  PubMed  CAS  Google Scholar 

  • Furberg H, Sullivan PF, Maes H, Prescott CA, Lerman C, Bulik C, Kendler KS (2005) The types of regular cigarette smokers: a latent class analysis. Nicotine Tob Res 7:351–360

    Article  PubMed  Google Scholar 

  • Gilbert DG (1995) Smoking: individual differences, psychopathology, and emotion. Taylor & Francis, London

    Google Scholar 

  • Gilbert DG, McClernon FJ (2000) A smoke cloud of confusion. Am Psychol 55:1158–1159

    Article  PubMed  CAS  Google Scholar 

  • Gilbert DG, McClernon FJ, Rabinovich NE, Dibb WD, Plath LC, Hiyane S, Jensen RA, Meliska CJ, Estes SL, Gehlbach BA (1999) EEG, physiology, and task-related mood fail to resolve across 31 days of smoking abstinence: relations to depressive traits, nicotine exposure, and dependence. Exp Clin Psychopharmacol 7:427–443

    Article  PubMed  CAS  Google Scholar 

  • Gilbert DG, McClernon FJ, Rabinovich NE, Plath LC, Masson CL, Anderson AE, Sly KF (2002) Mood disturbance fails to resolve across 31 days of cigarette abstinence in women. J Consult Clin Psychol 70:142–152

    Article  PubMed  Google Scholar 

  • Glass RM (1990) Blue mood, blackened lungs: depression and smoking. JAMA 264:1583–1584

    Article  PubMed  CAS  Google Scholar 

  • Goodman E, Capitman J (2000) Depressive symptoms and cigarette smoking among teens. Pediatrics 196:748–755

    Article  Google Scholar 

  • Hatzenbuehler LC, Parpal M, Matthews L (1983) Classifying college students as depressed or nondepressed using the Beck Depression Inventory: an empirical analysis. J Consult Clin Psychol 51:360–366

    Article  PubMed  CAS  Google Scholar 

  • Heffernan TM, Ling J, Parrott AC, Buchanan T, Scholey AB, Rodgers J (2005) Self-rated everyday and prospective memory abilities of cigarette smokers and non-smokers: a web based study. Drug Alcohol Depend 78:235–241

    Article  PubMed  CAS  Google Scholar 

  • Henningfield JE (1994) Do nicotine replacement medications work? A unique standard for nicotine. Addiction 89:434–436

    Article  PubMed  CAS  Google Scholar 

  • Hughes JR (1992) Tobacco withdrawal in self-quitters. J Consult Clin Psychol 60:689–697

    Article  PubMed  CAS  Google Scholar 

  • Hughes JR (2000) In: Piasecki M, Newhouse PA (eds) Forward to: nicotine in psychiatry. American Psychiatric, Washington, DC, p xiii–xvii

    Google Scholar 

  • Hughes JR, Hatsukami DK, Mitchell JE, Dahlgren LA (1986) Prevalence of smoking among psychiatric patients. Am J Psychiatry 143:993–997

    PubMed  CAS  Google Scholar 

  • Johnson JG, Cohen P, Pine DS, Klein DF, Kasen S, Brook JS (2000) Association between cigarette smoking and anxiety disorders during adolescence and early childhood. JAMA 284:2348–2351

    Article  PubMed  CAS  Google Scholar 

  • Johnson EO, Rhee SH, Chase GA, Breslau N (2004) Comorbidity of depression with levels of smoking: an exploration of the shared familial risk hypothesis. Nicotine Tob Res 6:1029–1038

    Article  PubMed  Google Scholar 

  • Jones MEE, Parrott AC (1997) Stress and arousal circadian rhythms in smokers and non-smokers working day and night shifts. Stress Med 13:91–97

    Article  Google Scholar 

  • Kassel JD (2000) Smoking and stress: correlation, causation, and context. Am Psychol 55:1155–1156

    Article  PubMed  CAS  Google Scholar 

  • Lasser K, Boyd JW, Woolhandler S, Himmelstein DU, McCormick D, Bor DH (2000) Smoking and mental illness: a population-based prevalence study. JAMA 284:2606–2610

    Article  PubMed  CAS  Google Scholar 

  • Lemay S, Chouinard S, Blanchet P, Masson H, Soland V, Beuter A, Bedard M-A (2004) Lack of efficacy of a nicotine transdermal treatment on motor and cognitive deficits in Parkinson’s Disease. Prog Neuropsychopharmacol Biol Psychiatry 28:31–39

    Article  PubMed  CAS  Google Scholar 

  • Lloyd B, Lucas K (1997) Smoking in adolescence: images and identities. Routledge, London

    Google Scholar 

  • Malone KM, Waternaux C, Haas GL, Cooper TB, Li S, Mann JJ (2003) Cigarette smoking, suicidal behavior, and serotonin function in major psychiatric disorders. Am J Psychiatry 160:773–779

    Article  PubMed  Google Scholar 

  • Maskos U, Molles BE, Pons S, Besson M, Guiard BP, Guilloux JP, Evrard A, Cazala P, Cormier A, Mameli-Engvall M, Dufour N, Cloez-Tayarani I, Bemelmans AP, Mallet J, Gardier AM, David V, Faure P, Granon S, Changeux JP (2005) Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors. Nature 436:103–107

    Article  PubMed  CAS  Google Scholar 

  • McGee R, Williams S, Poulton R, Moffitt T (2000) A longitudinal study of cannabis use and mental health from adolescence to early adulthood. Addiction 95:491–504

    Article  PubMed  CAS  Google Scholar 

  • McGhie A (1970) Attention and perception in schizophrenia. In: Maher BA (ed) Progress in experimental personality research, vol 5. Academic, New York

    Google Scholar 

  • Mitic WR, McGuire DP, Neumann B (1985) Perceived stress and adolescents’ cigarette use. Psychol Rep 57:1043–1048

    PubMed  CAS  Google Scholar 

  • Nesbitt PD (1973) Smoking, physiological arousal, and emotional response. J Pers Soc Psychol 25:137–144

    PubMed  CAS  Google Scholar 

  • Newhouse PA, Potter A, Singh A (2004) Effects of nicotinic stimulation on cognitive performance. Curr Opin Pharmacol 4:36–46

    Article  PubMed  CAS  Google Scholar 

  • Oquendo MA, Galfalvy H, Russo S, Ellis SP, Grunebaum MF, Burke A, Mann JJ (2004) Prospective study of clinical predictors of suicidal acts after a major depressive episode in patients with major depressive disorder or bipolar disorder. Am J Psychiatry 161:1433–1441

    Article  PubMed  Google Scholar 

  • Parrott AC (1985) Clobazam, personality, stress and performance. Roy Soc Med Internat Sympos Ser 74:47–58

    Google Scholar 

  • Parrott AC (1992) Smoking and smoking cessation: effects upon human performance. J Smok Relat Disord 3:43

    Google Scholar 

  • Parrott AC (1994a) Does cigarette smoking increase stress? Addiction 89:142–144

    Article  PubMed  CAS  Google Scholar 

  • Parrott AC (1994b) Individual differences in stress and arousal during cigarette smoking. Psychopharmacology 115:389–396

    Article  PubMed  CAS  Google Scholar 

  • Parrott AC (1995) Smoking cessation leads to reduced stress, but why? Int J Addict 30:1509–1516

    PubMed  CAS  Google Scholar 

  • Parrott AC (1998) Nesbitt’s paradox resolved? Stress and arousal modulation during cigarette smoking. Addiction 93:27–39

    Article  PubMed  CAS  Google Scholar 

  • Parrott AC (1999) Does cigarette smoking cause stress? Am Psychol 54:817–820

    Article  PubMed  CAS  Google Scholar 

  • Parrott AC (2000a) Cigarette smoking does cause stress. Am Psychol 55:1159–1160

    Article  PubMed  CAS  Google Scholar 

  • Parrott AC (2000b) Smoking and adverse childhood experiences: a reply to Anda. JAMA 283:1959

    PubMed  CAS  Google Scholar 

  • Parrott AC (2003) Cigarette-derived nicotine is not a medicine. World J Biol Psychiat 4:49–55

    Article  Google Scholar 

  • Parrott AC (2006) MDMA in humans: factors which affect the neuropsychobiological profiles of recreational Ecstasy users, the integrative role of bio-energetic stress. J Psychopharmacol 20 (in press)

  • Parrott AC, Craig D (1992) Cigarette smoking and nicotine gum (0, 2 and 4 mg): effects on four visual attention tasks. Neuropsychobiology 25:34–43

    Article  PubMed  CAS  Google Scholar 

  • Parrott AC, Garnham NJ (1998) Comparative mood states and cognitive skills of cigarette smokers, deprived smokers, and non-smokers. Hum Psychopharmacol 13:367–376

    Article  Google Scholar 

  • Parrott AC, Kaye FJ (1999) Daily uplifts, hassles, stresses and cognitive failures in cigarette smokers, abstaining smokers, and non-smokers. Behav Pharmacol 10:639–646

    Article  PubMed  CAS  Google Scholar 

  • Parrott AC, Roberts G (1991) Smoking deprivation and cigarette reinstatement: effects upon visual attention. J Psychopharmacol 5:402–407

    Google Scholar 

  • Parrott AC, Slater M (2000) Cigarette abstinence symptoms under stressful and relaxing conditions. Psychobiol News 34:13

    Google Scholar 

  • Parrott AC, Winder G (1989) Nicotine chewing gum (2 mg, 4 mg) and cigarette smoking: comparative effects upon vigilance and heart rate. Psychopharmacology 97:257–261

    Article  PubMed  CAS  Google Scholar 

  • Parrott AC, Garnham NJ, Wesnes K, Pincock C (1996) Cigarette smoking and abstinence: comparative effects upon cognitive task performance and mood state over 24 hours. Hum Psychopharmacol 11:391–400

    Article  Google Scholar 

  • Parrott AC, Thurkle J, Ward M (2000) Nicotine abstinence in regular smokers: mood and cognitive performance deficits after just one hour. J Psychopharmacol 14:a12

    Google Scholar 

  • Parrott A, Morinan A, Moss M, Scholey A (2004) Understanding drugs and behaviour. Wiley, Chichester

    Google Scholar 

  • Parrott AC, Margetson JK, Kissling C, Thome J (2005) Ecstasy, cigarettes, and inverse pleasure: nicotine use and abstinence symptoms in recreational Ecstasy/MDMA users. J Psychopharmacol 19:a27

    Article  Google Scholar 

  • Patton GC, Carlin JB, Coffey C, Wolfe R, Hibbert M, Bowes G (1998) Depression, anxiety, and smoking initiation: a prospective study over 3 years. Am J Public Health 88:1518–1522

    PubMed  CAS  Google Scholar 

  • Perkins KA, Grobe JE, Caggiula A, Wilson A, Stiller RL (1997) Acute reinforcing effects of low-dose nicotine nasal spray in humans. Pharmacol Biochem Behav 56:235–241

    Article  PubMed  CAS  Google Scholar 

  • Piasecki TM, Baker TB (2000) Does smoking amortize negative affect? Am Psychol 55:1156–1157

    Article  PubMed  CAS  Google Scholar 

  • Piasecki M, Newhouse PA (2000) Nicotine in Psychiatry. American Psychiatric, Washington DC

    Google Scholar 

  • Pineda JA, Herrera C, Kang C, Sandler A (1998) Effects of cigarette smoking and 12-h abstention on working memory during a serial-probe recognition task. Psychopharmacology 139:311–321

    Article  PubMed  CAS  Google Scholar 

  • Polen MR, Curry SJ, Grothaus LC, Bush TM, Hollis JF, Ludman EJ, McAfee TA (2004) Depressed mood and smoking experimentation among preteens. Psychol Addict Behav 18:194–198

    Article  PubMed  Google Scholar 

  • Potter AS, Newhouse PA (2004) Effects of acute nicotine administration on behavioral inhibition in adolescents with attention-deficit/hyperactivity disorder. Psychopharmacology 176:182–194

    Article  PubMed  CAS  Google Scholar 

  • Revell AD (1998) Smoking and performance: a puff-by-puff analysis. Psychopharmacology 96:563–565

    Article  Google Scholar 

  • Sacco KA, Termine A, Seyal A, Dudas MM, Vessicchio JC, Krishnan-Sarin S, Jatlow PI, Wexler BE, George TP (2005) Effects of cigarette smoking on spatial working memory and attentional deficits in schizophrenia: involvement of nicotinic receptor mechanisms. Arch Gen Psychiatry 62:649–659

    Article  PubMed  Google Scholar 

  • Schachter S (1978) Pharmacological and psychological determinants of smoking. In: Thornton RE (ed) Smoking behaviour, physiological and psychological influences. Churchill Livingstone, Edinburgh

    Google Scholar 

  • Sharpe, Gilbert DG (1998) Effects of repeated measurement of the Beck Depression Inventory and other measures of negative mood state. Personal Ind Diff 24:457–463

    Article  Google Scholar 

  • Shiffman S (1982) Relapse following smoking cessation: a situational analysis. J Consult Clin Psychol 50:71–86

    Article  PubMed  CAS  Google Scholar 

  • Shiffman S (1989) Tobacco chippers: individual differences in tobacco dependence. Psychopharmacology 97:539–547

    Article  PubMed  CAS  Google Scholar 

  • Shiffman S, West R, Gilbert D (2004) Recommendation for the assessment of tobacco craving and withdrawal in smoking cessation trials. Nicotine Tob Res 6:599–614

    Article  PubMed  Google Scholar 

  • Snyder FR, Henningfield JE (1989) Effects of nicotine administration following 12 hours of tobacco deprivation: assessment on computerized performance tasks. Psychopharmacology 97:17–22

    Article  PubMed  CAS  Google Scholar 

  • Spilich GJ (1994) Cognitive benefits of nicotine: fact or fiction? Addiction 89:141–142

    Article  PubMed  CAS  Google Scholar 

  • Spilich GJ, June L, Renner J (1992) Cigarette smoking and cognitive performance. Br J Addict 87:1313–1326

    Article  PubMed  CAS  Google Scholar 

  • Steuber TL, Danner F (2006) Adolescent smoking and depression: which comes first? Addict Behav 31:133–136

    Article  PubMed  Google Scholar 

  • Sullivan PF, Kendler KS (1999) The genetic epidemiology of smoking. Nicotine Tob Res 1(Suppl 2):S51–S57

    PubMed  Google Scholar 

  • Surgeon General (1988) Nicotine addiction: the Health consequences of smoking. US Department of Health, Maryland, USA

    Google Scholar 

  • Surgeon General (1990) Smoking cessation: the health benefits. US Department of Health, Maryland, USA

    Google Scholar 

  • Uhl GR (2004) Molecular genetics of substance abuse vulnerability: remarkable recent convergence of genome scan results. Ann N Y Acad Sci 1025:1–13

    Article  PubMed  CAS  Google Scholar 

  • Warburton DM (1988) The puzzle of nicotine use. In: Ney T, Gale A (eds) Smoking and human behaviour. Wiley, Chichester

    Google Scholar 

  • Warburton DM (1992) Smoking within reason. J Smok Relat Disord 3:55–59

    Google Scholar 

  • Wesnes K, Parrott AC (1992) Smoking, nicotine and human performance. In: Smith A, Jones DM (eds) Handbook of human performance, vol 2. Academic, London

    Google Scholar 

  • Wesnes K, Warburton DM (1987) Effects of smoking and nicotine on attention. In: Thornton RE (ed) Smoking behaviour: physiological and psychological influences. Churchill Livingstone, Edinburgh

    Google Scholar 

  • West R (1993) Beneficial effects of nicotine: fact or fiction? Addiction 88:589–590

    Article  PubMed  CAS  Google Scholar 

  • West R, Hajek P (1997) What happens to anxiety levels on giving up smoking? Am J Psychiatry 154:1589–1592

    PubMed  CAS  Google Scholar 

  • Wetter DW, Young TB (1994) The relation between cigarette smoking and sleep disturbance. Prev Med 23:328–334

    Article  PubMed  CAS  Google Scholar 

  • Witkiewitz K, Marlatt GA (2004) Relapse prevention for alcohol and drug problems: that was Zen, this is Tao. Am Psychol 59:224–235

    Article  PubMed  Google Scholar 

  • Wolter T, Hauri PJ, Schroeder DR (1997) Effects of 24-hour nicotine replacement on sleep and daytime activity during smoking cessation. Prev Med 25:601–610

    Article  Google Scholar 

  • Wu LT, Anthony JC (1999) Tobacco smoking and depressed mood in late childhood and early adolescence. Am J Public Health 89:1837–1840

    PubMed  CAS  Google Scholar 

  • Xian H, Scherrer JF, Madden PA, Lyons MJ, Tsuang M, True WR, Eisen SA (2005) Latent class typology of nicotine withdrawal: genetic contributions and association with failed smoking cessation and psychiatric disorders. Psychol Med 35:409–419

    Article  PubMed  Google Scholar 

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  1. Department of Psychology, University of Wales Swansea, Swansea, SA2 8PP, UK

    Andrew C. Parrott

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Parrott, A.C. Nicotine psychobiology: how chronic-dose prospective studies can illuminate some of the theoretical issues from acute-dose research. Psychopharmacology 184, 567–576 (2006). https://doi.org/10.1007/s00213-005-0294-y

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