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Alcohol-induced impairment of behavioral control: differential effects on engaging vs. disengaging responses

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Abstract

Rationale

Model-based assessments of behavioral control have been used to study the acute effects of alcohol on the ability to execute and inhibit behavioral responses. Response inhibition appears more vulnerable to the impairing effects of alcohol than response execution. Current information processing models have yet to account for this observation.

Objectives

The present study used a reductionist approach to determine if the particular vulnerability of response inhibition to the effects of alcohol occurs at the level of the action (motor program). The study examined the effects of alcohol on the ability to execute and inhibit behavior in a context in which preliminary information signaled the likelihood that a response should be executed or suppressed. The engagement and disengagement of responses were directly compared under alcohol.

Methods

Adults (N=24) performed a cued go/no-go task that required quick responses to go targets and suppression of responses to no-go targets. Response requirements were manipulated by varying the nature of the action required whereby half of the participants made key press responses (response engagement) and the other half released ongoing key presses (response disengagement). Performance was tested under three doses of alcohol: 0.00, 0.45, and 0.65 g/kg.

Results

Dose-dependent increases in commission errors were only observed with response engagement and not with response disengagement. Reaction times were faster for response engagement than response disengagement.

Conclusions

Response disengagement affords some protection against alcohol-induced impairment of inhibition, indicating that not all aspects of motor processing requiring inhibition are equally impaired by alcohol.

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Acknowledgements

This research was supported by Grant R01 AA12895 from the National Institute on Alcohol Abuse and Alcoholism.

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Authors and Affiliations

  1. Department of Psychology, University of Kentucky, Lexington, KY, 40506-0044, USA

    Cecile A. Marczinski, Ben D. Abroms & Mark T. Fillmore

  2. Department of Psychology, San Jose State University, San Jose, CA, USA

    Mark Van Selst

Authors
  1. Cecile A. Marczinski
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  2. Ben D. Abroms
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  3. Mark Van Selst
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  4. Mark T. Fillmore
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Correspondence to Mark T. Fillmore.

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Marczinski, C.A., Abroms, B.D., Van Selst, M. et al. Alcohol-induced impairment of behavioral control: differential effects on engaging vs. disengaging responses. Psychopharmacology 182, 452–459 (2005). https://doi.org/10.1007/s00213-005-0116-2

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  • DOI: https://doi.org/10.1007/s00213-005-0116-2

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