Abstract
Fractures are more prevalent among people with severe and profound developmental disabilities than in the general population. In order to characterize the tendency of these people to fracture, and to identify features that may guide the development of preventive strategies, we analyzed fracture epidemiology in people with severe and profound developmental disabilities who lived in a stable environment. Data from a 23-year longitudinal cohort registry of 1434 people with severe and profound developmental disabilities were analyzed to determine the effects of age, gender, mobility, bone fractured, month of fracture, and fracture history upon fracture rates. Eighty-five percent of all fractures involved the extremities. The overall fracture rate increased as mobility increased. In contrast, femoral shaft fracture risk was substantially higher in the least mobile [relative risk (RR), 10.36; 95% confidence interval (CI), 3.29–32.66] compared with the most mobile group. Although the overall fracture rate was not associated with age, the femoral shaft fractures decreased but hand/foot fractures increased with age. Overall fracture risk declined in August and September (RR, 0.70; 95% CI, 0.55–0.89), being especially prominent for tibial/fibular fractures (RR, 0.31; 95% CI, 0.13–0.70). Gender was not a factor in fracture risk. Two primary fracture mechanisms are apparent: one, largely associated with lack of weight-bearing in people with the least mobility, is exemplified by femoral fractures during non-traumatic events as simple as diapering or transfers; the other, probably due to movement- or fall-related trauma, is exemplified by hand/foot fractures in people who ambulate. The fracture experience of people with severe and profound developmental disabilities is unique and, because it differs qualitatively from postmenopausal osteoporosis, may require population-specific methods for assessing risk, for improving bone integrity, and for reduction of falls and accidents.
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APA (1994) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Association, Washington D.C.
Tannenbaum TN, Lipworth L, Baker S (1989) Risk of fractures in an intermediate care facility for persons with mental retardation. Am J Mental Retardation 93:444–451
Lohiya G, Crinella FM, Tan-Figueroa L et al. (1999) Fracture epidemiology and control in a developmental center. West J Med 170:203–209
Peabody TD, Stasikelis PJ (1999) Fractures in adults at an institution for the developmentally disabled. Clin Orthop Rel Res 366:217–220
Henderson RC, Lin PP, Greene WB. (1995) Bone density in children and adolescents who have spastic cerebral palsy. J Bone Joint Surg 77-A:1671–1681
Henderson RC (1997) Bone density and other possible predictors of fracture risk in children and adolescents with spastic quadriplegia. Dev Med Child Neurol 39:224–227
Ryder KM, Williams J, Womack C et al. (2003) Appendicular fractures: a significant problem among institutionalized adults with developmental disabilities. Am J Mental Retardation 108:340–346
Opitz JM, Hermann J, Pettersen JC et al. (1979) Terminological, diagnostic, nosological, and anatomical-developmental aspects of developmental defects in man. Adv Hum Genet l9:71–164
Food and Nutrition Board, National Academy of Sciences (1974, 1980, 1989) Recommended daily allowances. National Academy Press, Washington, D.C.
Fischer MH, Adkins WN Jr, Liebl BH et al. (1988) Bone status in nonambulant, epileptic, institutionalized youth. Clin Ped 27:499–505
Baer MT, Kozlowski BW, Blyler EM et al. (1997) Vitamin D, calcium, and bone status in children with developmental delay in relation to anticonvulsant use and ambulatory status. Am J Clin Nutr 65:1042–1051
Ahlborg HG, Johnell O, Turner CH et al. (2003) Bone loss and bone size after menopause. N Eng J Med 349:327–334
LeBlanc AD, Schneider VS, Evans HJ et al. (1990) Bone mineral loss and recovery after 17 weeks of bed rest. J Bone Miner Res 5:843–850
Vieth R, Cole DE, Hawker GA et al. (2001) Wintertime vitamin D insufficiency is common in young Canadian women, and their vitamin D intake does not prevent it. Eur J Clin Nutr 55:1091–1097
Rapuri PB, Kinyamu HK, Gallagher JC et al. (2002) Seasonal changes in calciotropic hormones, bone markers, and bone mineral density in elderly women. J Clin Endocrinol Metab 87:2024–2032
Jekovec-Vrhovsěk M, Kocijančič A, Prež J. (2000) Effect of vitamin D and calcium on bone mineral density in children with CP and epilepsy in full-time care. Dev Med Chil Neurol 42:403–405
Scherenberger RC (1992) An exploratory study of accidents and injuries among residents in public residential facilities. Superintendents’ Digest 11:47–59
Frosen L, Sogaard AJ, Meyer HE, et al. (1999) Survival after hip fracture: short-and long-term excess mortality according to age and gender. Osteoporos Int 10:73–78
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Glick, N.R., Fischer, M.H., Heisey, D.M. et al. Epidemiology of fractures in people with severe and profound developmental disabilities. Osteoporos Int 16, 389–396 (2005). https://doi.org/10.1007/s00198-004-1708-0
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DOI: https://doi.org/10.1007/s00198-004-1708-0