Skip to main content
SpringerLink
Log in

The hidden pulmonary dysfunction in acute lung injury

  • Editorial
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Aboab J, Jonson B, Kouatchet A, Taille S, Niklason L, Brochard L (2006) Effect of inspired oxygen fraction on alveolar derecruitment in acute respiratory distress syndrome. Intensive Care Med DOI 10.1007/s00134-006-0382-4

  2. Gattinoni L, Caironi P, Pelosi P, Goodman LR (2001) What has computed tomography taught us about the acute respiratory distress syndrome? Am J Respir Crit Care 164:1701–1711

    CAS  Google Scholar 

  3. Hubmayr RD (2002) Perspective on lung injury and recruitment: a skeptical look at the opening and collapse story. Am J Respir Crit Care Med 165:1647–1653

    Article  PubMed  Google Scholar 

  4. Santos C, Ferrer M, Roca J, Torres A, Hernandez C, Rodriguez-Roisin R (2000) Pulmonary gas exchange response to oxygen breathing in acute lung injury. Am J Respir Crit Care Med 161:26–31

    PubMed  CAS  Google Scholar 

  5. Suter P, Fairley H, Schlobohm R (1975) Shunt, lung volume and perfusion during short periods of ventilation with oxygen. Anesthesiology 43:617–627

    Article  PubMed  CAS  Google Scholar 

  6. Lemaire F, Matamis D, Lampron N, Teisseire B, Harf A (1985) Intrapulmonary shunt is not increased by 100% oxygen ventilation in acute respiratory failure. Bull Eur Physiopathol Respir 21:251–256

    PubMed  CAS  Google Scholar 

  7. Barbera JA, Roger N, Roca J, Rovira I, Higenbottam TW, Rodriguez-Roisin R (1996) Worsening of pulmonary gas exchange with nitric oxide inhalation in chronic obstructive pulmonary disease. Lancet 347:436–440

    Article  PubMed  CAS  Google Scholar 

  8. Rylander C, Tylen U, Rossi-Norrlund R, Herrmann P, Quintel M, Bake B (2005) Uneven distribution of ventilation in acute respiratory distress syndrome. Crit Care 9:R165–R171

    Article  PubMed  Google Scholar 

  9. West JB (1977) State of the art: Ventilation-perfusion relationships. Am Rev Respir Dis 116:919–943

    PubMed  CAS  Google Scholar 

  10. Gunnarsson L, Tokics L, Gustavsson H, Hedenstierna G (1991) Influence of age on atelectasis, formation and gas exchange impairment during general anaesthesia. Br J Anaesth 66:423–432

    PubMed  CAS  Google Scholar 

  11. Leblanc P, Ruff F, Milic-Emili J (1970) Effects of age and body position on “airway closure” in man. J Appl Physiol 28:448–451

    PubMed  CAS  Google Scholar 

  12. Dantzker DR, Wagner PD, West JB (1975) Instability of lung units with low VA/Q ratios during O2 breathing. J Appl Physiol 38:886–895

    Google Scholar 

  13. Rothen HU, Sporre B, Engberg G, Wegenius G, Reber A, Hedenstierna G (1995) Prevention of atelectasis during general anaesthesia. Lancet 345:1387–1391

    Article  PubMed  CAS  Google Scholar 

  14. Edmark L, Kostova-Aherdan K, Enlund M, Hedenstierna G (2003) Optimal oxygen concentration during induction of general anesthesia. Anesthesiology 98:28–33

    Article  PubMed  CAS  Google Scholar 

  15. Rothen HU, Sporre B, Engberg G, Wegenius G, Högman M, Hedenstierna G (1995) Influence of gas composition on recurrence of atlectasis after a reexpansion maneuver during general anesthesia. Anesthesiology 82:832–842

    Article  PubMed  CAS  Google Scholar 

  16. Neumann P, Rothen HU, Berglund JE, Valtysson J, Magnusson L, Hedenstierna G (1999) Positive end-expiratory pressure prevents atelectasis during general anaesthesia even in the presence of a high inspired oxygen concentration. Acta Anaesthesiol Scand 43:295–301

    Article  PubMed  CAS  Google Scholar 

  17. Dyhr T, Laursen N, Larsson A (2002) Effects of lung recruitment maneuver and positive end-expiratory pressure on lung volume, respiratory mechanics and alveolar gas mixing in patients ventilated after cardiac surgery. Acta Anaesthesiol Scand 46:717–725

    Article  PubMed  Google Scholar 

  18. Ranieri VM, Suter PM, Tortorella C, De Tullio R, Dayer JM, Brienza A, Bruno F, Slutsky AS (1999) Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. JAMA 282:54–61

    Article  PubMed  CAS  Google Scholar 

  19. Frostell C, Blomqvist H, Hedenstierna G, Halbig I, Pieper R (1987) Thoracic and abdominal lymph drainage in relation to mechanical ventilation and PEEP. Acta Anaesthesiol Scand 31:405–411

    Article  PubMed  CAS  Google Scholar 

  20. Lattuada M, Hedenstierna G (2006) Abdominal lymph flow in an endotoxin sepsis model: influence of spontaneous breathing and mechanical ventilation. Crit Care Med (in press)

Download references

Author information

Authors and Affiliations

  1. Department of Medical Sciences, Clinical Physiology, University Hospital, 75185, Uppsala, Sweden

    Göran Hedenstierna

Authors
  1. Göran Hedenstierna
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Göran Hedenstierna.

Additional information

This editorial refers to the article available at: http://dx.doi.org/10.1007s/s00134-006-0382-4

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hedenstierna, G. The hidden pulmonary dysfunction in acute lung injury. Intensive Care Med 32, 1933–1934 (2006). https://doi.org/10.1007/s00134-006-0383-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00134-006-0383-3

Search

Navigation