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Anxiety and depression, chronic physical conditions, and quality of life in an urban population sample study

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Abstract

Objective

No previous studies have empirically demonstrated a multiplicative interactive effect of anxiety disorders and/or depression (ADD) and chronic medical conditions on quality of life (QOL). We hypothesized that QOL impairment was worsened by the presence of ADD and medical co-morbidity, more than when it was with either medical co-morbidity alone or ADD alone.

Methods

Complete data of 2,801 participants from the National Mental Health Survey of Adults in Singapore were analyzed, using SCAN diagnoses of anxiety disorders and depression, self-reports of chronic medical conditions, and SF-12 measures of QOL (Mental Component Summary, MCS, and Physical Component Summary, PCS).

Results

Persons diagnosed with ADD (compared to those without) had considerably more medical co-morbidities (59 vs. 33%, p < 0.001). In multiple regression analyses, ADD (vs. no ADD) was associated with lower PCS (b = −1.013, p = 0.045) and MCS scores (b = −9.912, p < 0.001), as was number of medical co-morbidities (0, 1–2, 3 +), PCS scores (b = −2.058, p < 0.001) and MCS scores (b = −1.138, p < 0.001). There were significant interactive effects of medical co-morbidities and ADD on PCS (p < 0.001), and MCS (p = 0.086), suggesting that the negative effects of medical conditions on quality of life was aggravated non-additively by the co-morbid presence of ADD, and vice versa.

Conclusion

The individual effects of medical and psychiatric morbidity on functional status and quality of life were considerably worse when both were present in the same individual. Future studies should examine the impact of identifying and treating anxiety and depressive disorders in patients with medical problems for better outcomes.

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Acknowledgments

Funding support for the research was provided by grants from the National Medical Research Council, Ministry of Health (NMRC/0572/2001 and NMRC/0641/2002).

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Authors and Affiliations

  1. Department of Psychiatry, Singapore General Hospital, Outram Road, Singapore, 169608, Singapore

    Leslie Lim

  2. National Registry of Diseases Office, Health Promotion Board, 3 Second Hospital Avenue, Singapore, 168937, Singapore

    Ai-Zhen Jin

  3. Department of Psychological Medicine, National University of Singapore, NUHS Tower Block, Level9 1E, Kent Ridge Road, Singapore, 119228, Singapore

    Tze-Pin Ng

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  1. Leslie Lim
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Correspondence to Leslie Lim.

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Lim, L., Jin, AZ. & Ng, TP. Anxiety and depression, chronic physical conditions, and quality of life in an urban population sample study. Soc Psychiatry Psychiatr Epidemiol 47, 1047–1053 (2012). https://doi.org/10.1007/s00127-011-0420-6

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