Zusammenfassung
Depression und Diabetes mellitus Typ 2 kommen häufig gemeinsam vor. Beide Erkrankungen erhöhen das Risiko der Inzidenz der anderen Erkrankung und verschlechtern deren Prognose. Daher ist es für Nervenärzte bedeutsam, depressive Patienten als Diabetesrisikoprobanden zu behandeln und entsprechend auf metabolische Risiken zu untersuchen sowie bei der antidepressiven Therapie metabolische Risiken zu meiden.
Summary
Depression and diabetes mellitus type 2 are frequently comorbid conditions. Both disorders may increase the incidence of the other disorder and impair the prognosis. Thus, it is important for psychiatrists to consider depressed patients as high-risk diabetes subjects to screen for metabolic risks and to consider metabolic risks of antidepressant treatment.
Literatur
Okamura F, Tashiro A, Utumi A et al (2000) Insulin resistance in patients with depression and its changes during the clinical course of depression: minimal model analysis. Metabolism 49:1255–1260
Weber B, Schweiger U, Deuschle M, Heuser I (2000) Major depression and impaired glucose tolerance. Exp Clin Endocrinol Diabetes 108:187–190
Weber-Hamann B, Kopf D, Lederbogen F et al (2005) Activity of the hypothalamus-pituitary-adrenal system and oral glucose tolerance in depressed patients. Neuroendocrinology 81:200–204
Reynolds RM, Labad J, Strachan MWJ et al (2010) Elevated fasting plasma cortisol is associated with ischemic heart disease and its risk factors in people with type 2 diabetes: the Edinburgh type 2 diabetes study. J Clin Endocrinol Metab 95:1602–1608
Lawlor DA, Smith GD, Ebrahim S (2003) Association of insulin resistance with depression: cross sectional findings from the British women‘ s heart and health study. BMJ 327:1383–1384
Timonen M, Salmenkaita I, Jokelainen J et al (2007) Insulin resistance and depressive symptoms in young adult males: findings from Finnish military conscripts. Psychosom Med 69:723–728
Kinder LS, Carnethon M, Palaniappan L et al (2004) Depression and the metabolic syndrome in young adults: findings from the Third National Health and Nutrition Examination Survey. Psychosom Med 66:316–322
Anderson RJ, Freedland KE, Clouse RE LP (2001) The prevalence of comorbid depression in adults with diabetes. Diabetes Care 24:1069–1078
Lustman PJ, Griffith LS, Freedland KE, Clouse RE (1997) The course of major depression in diabetes. Gen Hosp Psychiatry 19:138–143
Rubin RR, Ciechanowski P, Egede LE, Lin EH LP (2004) Recognizing and treating depression in patients with diabetes. Curr Diab Rep 4:119–125
Räikkönen K, Matthews K, Kuller LH (2002) The relationship between psychological risk attributes and the metabolic syndrome in healthy women: antecedent or consequence? Metabolism 51:1573–1577
McCaffery JM, Niaura R, Todaro J et al (2003) Depressive symptoms and metabolic risk in adult male twins enrolled in the National Heart, Lung, and Blood Institute Twin Study. Psychosom Med 65:490–497
Vogelzangs N, Penninx B (2007) Cortisol and insulin in depression and metabolic syndrome. Psychoneuroendocrinol 32:856
Golden SH, Williams JE, Ford DE et al (2004) Depressive symptoms and the risk of type 2 diabetes: The Atherosclerosis Risk in Communities Study. Diabetes Care 27:429–435
Kumari M, Head J, Marmot M (2004) Prospective study of social and other risk factors for incidence of type 2 diabetes in the Whitehall II Study. Arch Intern Med 164:1873–1880
Eaton WW, Armenian H, Gallo J et al (1996) Depression and risk for onset of type II diabetes. A prospective population-based study. Diabetes Care 19:1097–1102
Kawakami N, Takatsuka N, Shimizu H, Ishhibashi H (1999) Depressive symptoms and occurrence of type 2 diabetes among japanese men. Diabetes Care 22:1071–1076
Everson-Rose SA, Meyer PM, Powell LH et al (2004) Depressive symptoms, insulin resistance, and risk of diabetes in women at midlife. Diabetes Care 27:2856–2862
Knol MJ, Twisk JWR, Beekman ATF et al (2006) Depression as a risk factor for the onset of type 2 diabetes mellitus. A meta-analysis. Diabetologia 49:837–845
Mezuk B, Eaton WW, Albrecht S, Golden SH (2008) Depression and type 2 diabetes over the lifespan: a meta-analysis. Diabetes Care 31:2383–2390
Boyko EJ, Courten M de, Zimmet PZ et al (2000) Features of the metabolic syndrome predict higher risk of diabetes and impaired glucose tolerance: a prospective study in Mauritius. Diabetes Care 23:1242–1248
Ford ES, Li C, Sattar N (2008) Metabolic syndrome and incident diabetes: current state of the evidence. Diabetes Care 31:1898–1904
Pan A, Keum N, Okereke OI et al (2012) Bidirectional association between depression and metabolic syndrome: a systematic review and meta-analysis of epidemiological studies. Diabetes Care 35:1242–1248
Vogelzangs N, Kritchevsky SB, Beekman ATF et al (2010) Obesity and onset of significant depressive symptoms: results from a prospective community-based cohort study of older men and women. J Clin Psychiatry 71:391–399
Groot M de, Anderson R, Freedland KE, Clouse RE LP (2001) Association of depression and diabetes complications: a meta-analysis. Psychosom Med 63:619–630
Lin EH, Rutter CM, Katon W et al (2010) Depression and advanced complications of diabetes. Diabetes Care 33:264–269
Nouwen A, Nefs G, Caramlau I et al (2011) Prevalence of depression in individuals with impaired glucose metabolism or undiagnosed diabetes: a systematic review and meta-analysis of the European Depression in Diabetes (EDID) Research Consortium. Diabetes Care 34:752–762
Li ZB, Ho SY, Chan WM et al (2004) Obesity and depressive symptoms in Chinese elderly. Int J Geriatr Psychiatry 19:68–74
Friedman MA, Brownell KD (1995) Psychological correlates of obesity: moving to the next research generation. Psychol Bull 117:3–20
Onyike CU (2003) Is obesity associated with major depression? Results from the Third National Health and Nutrition Examination Survey. Am J Epidemiol 158:1139–1147
Herva A, Laitinen J, Miettunen J et al (2006) Obesity and depression: results from the longitudinal Northern Finland 1966 Birth Cohort Study. Int J Obes 30:520–527
Pine DS, Cohen P, Brook J, Coplan JD (1997) Psychiatric symptoms in adolescence as predictors of obesity in early adulthood: a longitudinal study. Am J Public Health 87:1303–1310
Hasler G, Pine DS, Kleinbaum DG et al (2005) Depressive symptoms during childhood and adult obesity: the Zurich Cohort Study. Mol Psychiatry 10:842–850
Arner P (2005) Human fat cell lipolysis: biochemistry, regulation and clinical role. Best Pract Res Clin Endocrinol Metab 19:471–482
Park HS, Lee K (2005) Greater beneficial effects of visceral fat reduction compared with subcutaneous fat reduction on parameters of the metabolic syndrome: a study of weight reduction programmes in subjects with visceral and subcutaneous obesity. Diabet Med 22:266–272
Ahlberg A-C, Ljung T, Rosmond R et al (2002) Depression and anxiety symptoms in relation to anthropometry and metabolism in men. Psychiatry Res 112:101–110
Kahl KG, Bester M, Greggersen W et al (2005) Visceral fat deposition and insulin sensitivity in depressed women with and without comorbid borderline personality disorder. Psychosom Med 67:407–412
Thakore JH, Richards PJ, Reznek RH et al (1997) Increased intra-abdominal fat deposition in patients with major depressive illness as measured by computed tomography. Biol Psychiatry 41:1140–1142
Weber-Hamann B, Hentschel F, Kniest A et al (2002) Hypercortisolemic depression is associated with increased intra-abdominal fat. Psychosom Med 64:274–277
Weber-Hamann B, Werner M, Hentschel F et al (2006) Metabolic changes in elderly patients with major depression: evidence for increased accumulation of visceral fat at follow-up. Psychoneuroendocrinology 31:347–354
Wong SYS, Leung JC, Leung PC, Woo J (2011) Depressive symptoms and change in abdominal obesity in the elderly: positive or negative association? Am J Geriatr Psychiatry 19:730–742
McCaffery JM, Duan QL, Frasure-smith N, Lespérance F et al (2010) Genetic predictors of depressive symptoms in cardiac patients. Am J Med Genet B Neuropsychiatr Genet 150:381–388
Scherrer JF, Xian H, Lustman PJ et al (2011) A test for common genetic and environmental vulnerability to depression and diabetes. Twin Res Hum Genet 14:169–172
Gale CR, Martyn CN (2012) Birth weight and later risk of depression in a national birth cohort Birth weight and later risk of depression in a national birth cohort. Br J Psychiatry 184:28–33
Thompson C, Syddall H, Rodin I et al (2001) Birth weight and the risk of depressive disorder in late life. Br J Psychiatry 179:450–455
Leibson CL, Burke JP, Ransom JE et al (2005) Relative risk of mortality associated with diabetes as a function of birth weight. Diabetes Care 28:2839–2843
Lawlor D, Ronalds G, Clark H et al (2005) Birth weight is inversely associated with incident coronary heart disease and stroke among individuals born in the 1950s: findings from the Aberdeen Children of the 1950s prospective cohort study. Circulation 112:1414–1418
Reynolds RM, Walker BR, Syddall HE et al (2005) Is there a gender difference in the associations of birthweight and adult hypothalamic-pituitar-adrenal axis activity? Eur J Endocrinol 152:249–253
Sattar N, McConnachie A, O’Reilly D et al (2004) Inverse association between birth weight and C-reactive protein concentrations in the MIDSPAN Family Study. Arterioscler Thromb Vasc Biol 24:583–587
Schmid B, Blomeyer D, Buchmann AF et al (2011) Quality of early mother-child interaction associated with depressive psychopathology in the offspring: a prospective study from infancy to adulthood. J Psychiatr Res 45:1387–1394
Buchmann AF, Kopf D, Westphal S et al (2010) Impact of early parental child-rearing behavior on young adults‘ cardiometabolic risk profile: a prospective study. Psychosom Med 72:156–162
Veenema AH, Meijer OC, Kloet ER de, Koolhaas JM (2003) Genetic selection for coping style predicts stressor susceptibility. J Neuroendocrinol 15:256–267
Michel C, Levin BE, Dunn-Meynell A (2003) Stress facilitates body weight gain in genetically predisposed rats on medium-fat diet. Am J Physiol Regul Integr Comp Physiol 285:R791–799
Peters A, Schweiger U, Pellerin L et al (2004) The selfish brain: competition for energy resources. Neurosci Biobehav Rev 28:143–180
Otte C, Neylan TC, Pipkin SS et al (2009) Depressive symptoms and 24-hour urinary norepinephrine excretion levels in patients with coronary disease: findings from the Heart and Soul Study. Am J Psychiatry 162:2139–2145
Deuschle M, Schweiger U, Weber B et al (1997) Diurnal activity and pulsatility of the hypothalamus-pituitary-adrenal system in male depressed patients and healthy controls. J Clin Endocrinol Metab 82:234–238
Schweiger U, Greggersen W, Rudolf S et al (2008) Disturbed glucose disposal in patients with major depression; application of the glucose clamp technique. Psychosom Med 70:170–176
Peters A, Kubera B, Hubold C, Langemann D (2011) The selfish brain: stress and eating behavior. Front Neurosci 5:74
Licht CMM, Vreeburg SA, Reedt Dortland AKB van et al (2010) Increased sympathetic and decreased parasympathetic activity rather than changes in hypothalamic-pituitary-adrenal axis activity is associated with metabolic abnormalities. J Clin Endocrinol Metab 95:2458–2466
Robertson SM, Stanley MA, Cully JA, Naik AD (2012) Positive emotional health and diabetes care: concepts, measurement, and clinical implications. Psychosomatics 53:1–12
Vitry AI, Roughead EE, Preiss AK et al (2010) Influence of comorbidities on therapeutic progression of diabetes treatment in Australian veterans: a cohort study. PloS One 5:e14024
Kirmayer LJ, Looper KJ (2006) Abnormal illness behaviour: physiological, psychological and social dimensions of coping with distress. Curr Opin Psychiatry 19:54–60
Abrams RC, Lachs M, McAvay G et al (2002) Predictors of self-neglect in community-dwelling elders. Am J Psychiatry 159:1724–1730
Ziegelstein RC, Fauerbach JA, Stevens SS et al (2000) Patients with depression are less likely to follow recommendations to reduce cardiac risk during recovery from a myocardial infarction. Arch Intern Med 160:1818–1823
Lin EHB, Katon W, Von Korff M et al (2004) Relationship of depression and diabetes self-care, medication adherence, and preventive care. Diabetes Care 27:2154–2160
Gehi A, Haas D, Pipkin S, Whooley M (2005) Depression and medication adherence in outpatients with coronary heart disease: findings from the Heart and Soul Study. Arch Intern Med 165:2508–2513
Ciechanowski P, Russo J, Katon W et al (2004) Influence of patient attachment style on self-care and outcomes in diabetes. Psychosom Med 66:720–728
Gonzalez JS, Peyrot M, McCarl LA et al (2008) Depression and diabetes treatment non-adherence: a meta-analysis. Diabetes Care 31:2398–2403
Makine C, Karíıda Ç, Kadıo P et al (2009) Symptoms of depression and diabetes-specific emotional distress are associated with a negative appraisal of insulin therapy in insulin-naive patients with Type 2 diabetes mellitus. A study from the European Depression. Diabet Med 26:28–33
Lustman PJ, Anderson RJ, Freedland KE et al (2000) Depression and poor glycemic control: a meta-analytic review of the literature. Diabetes Care 23:934–942
Heckbert SR, Rutter CM, Oliver M et al (2010) Depression in relation to long-term control of glycemia, blood pressure, and lipids in patients with diabetes. J Gen Intern Med 25:524–529
Waitzfelder B, Gerzoff RB, Karter AJ et al (2010) Correlates of depression among people with diabetes: The Translating Research Into Action for Diabetes (TRIAD) study. Prim Care Diabetes 4:215–222
Daly JM, Hartz AJ, Xu Y et al (2009) An assessment of attitudes, behaviors, and outcomes of patients with type 2 diabetes. J Am Board Fam Med 22:280–290
Katon W, Russo J, Lin EHB et al (2009) Diabetes and poor disease control: is comorbid depression associated with poor medication adherence or lack of treatment intensification? Psychosom Med 71:965–972
Goodwin RD (2003) Association between physical activity and mental disorders among adults in the United States. Prev Med 36:698–703
Mwamburi DM, Liebson E, Folstein M et al (2011) Depression and glycemic intake in the homebound elderly. J Affect Disord 132:94–98
Ludman EJ, Katon W, Russo J et al (2004) Depression and diabetes symptom burden. Gen Hosp Psychiatry 26:430–436
Simon GE, Von Korff M, Lin E (2005) Clinical and functional outcomes of depression treatment in patients with and without chronic medical illness. Psychol Med 35:271–279
Ali S, Stone M, Skinner TC et al (2010) The association between depression and health-related quality of life in people with type 2 diabetes: a systematic literature review. Diabetes Metab Res Rev 26:75–89
Gilmer TP, O’Connor PJ, Rush WA et al (2005) Predictors of health care costs in adults. Diabetes Care 28:59–64
Clouse RE, Lustman PJ, Freedland KE et al (2003) Depression and coronary heart disease in women with diabetes. Psychosom Med 65:376–383
Davydow DS, Russo JE, Ludman E, Lin EHB et al (2012) The association of comorbid depression with intensive care unit admission in patients with diabetes: a prospective cohort study. Psychosomatics 52:117–126
Katon W, Lyles CR, Parker MM et al (2012) Association of depression with increased risk of dementia in patients with type 2 diabetes: the diabetes and aging study. Arch Gen Psychiatry 69:410–417
Scherrer JF, Garfield LD, Chrusciel T et al (2011) Increased risk of myocardial infarction in depressed patients with type 2 diabetes. Diabetes Care 34:1729–1734
Lin EH, Heckbert SR, Rutter CM et al (2009) Depression and Increased mortality in diabetes: unexpected causes of death. Ann Fam Med 7:414–421
Katon WJ, Rutter C, Simon G et al (2005) The association of comorbid depression with mortality in patients with type 2 diabetes. Diabetes Care 28:2668–2672
Iosifescu DV, Bankier B, Fava M (2004) Impact of medical comorbid disease on antidepressant treatment of major depressive disorder. Curr Psychiatry Rep 6:193–201
Lustman PJ, Griffith LS, Clouse RE et al (1997) Effects of nortriptyline on depression and glycemic control in diabetes: results of a double-blind, placebo-controlled trial. Psychosom Med 250:241–250
Lustman PJ, Freedland KE, Griffith LS, Clouse RE (2000) Fluoxetine for depression in diabetes: a randomized double-blind placebo-controlled trial. Diabetes Care 23:618–623
Lustman PJ, Griffith LS, Freedland KE et al (1998) Cognitive behavior therapy for depression in type 2 diabetes mellitus a randomised controlled trial. Ann Intern Med 129:613–621
Bastelaar KMP van, Pouwer F, Cuijpers P et al (2011) Web-based depression treatment for type 1 and type 2 diabetic patients. Diabetes Care 34:320–325
Williams JW Jr, Katon W, Lin EH et al (2004) The effectiveness of depression care management on diabetes-related outcomes in older patients. Ann Intern Med 140:1015–1024
Katon WJ, Von Korff M, Lin EH et al (2004) The Pathways Study: a randomized trial of collaborative care in patients with diabetes and depression. Arch Gen Psychiatry 61:1042–1049
Sayuk GS, Gott BM, Nix BD, Lustman PJ (2011) Improvement in sexual functioning in patients with type 2 diabetes and depression treated with bupropion. Diabetes Care 34:332–334
Anderson RJ, Gott BM, Sayuk GS et al (2010) Antidepressant pharmacotherapy in adults with type 2 diabetes rates and predictors of initial response. Diabetes Care 33:485–489
Lustman PJ, Clouse RE, Nix BD et al (2006) Sertraline for prevention of depression recurrence in diabetes mellitus. Arch Gen Psychiatry 63:521–529
Katon WJ, Lin EHB, Russo JE et al (2008) Long-term effects on medical costs of improving depression outcomes in patients with depression and diabetes. Diabetes Care 31:1155–1159
Simon GE, Katon WJ, Lin EHB et al (2007) Cost-effectiveness of systematic depression treatment among people with diabetes mellitus. Arch Gen Psychiatry 64:65–72
Katon W, Unützer J, Fan MY et al (2006) Cost-effectiveness and net benefit of enhanced treatment of depression for older adults with diabetes. Diabetes Care 29:265–270
Katon WJ, Simon G, Russo J et al (2004) Quality of depression care in a population-based sample of patients with diabetes and major depression. Med Care 42:1222–1229
Paile-Hyvärinen M, Wahlbeck K, Eriksson JG (2007) Quality of life and metabolic status in mildly depressed patients with type 2 diabetes treated with paroxetine: a double-blind randomised placebo controlled 6-month trial. BMC Fam Pract 8:34
Goodnick PJ, Kumar A, Henry JH et al (1997) Sertraline in coexisting major depression and diabetes mellitus. Psychopharmacol Bull 33:261–264
Goldstein DJ, Lu Y, Detke MJ et al (2005) Duloxetine vs. placebo in patients with painful diabetic neuropathy. Pain 116:109–118
Lustman PJ, Williams MM, Sayuk GS et al (2007) Factors influencing glycemic control in type 2 diabetes during acute- and maintenance-phase treatment of major depressive disorder with bupropion. Diabetes Care 30:459–466
Gregg J, Callaghan GM, Hayes SC, Glenn-Lawson JL (2007) Improving diabetes self-management through acceptance, mindfulness, and values: a randomized controlled trial. J Consult Clin Psychol 75:336–343
Lin EH, Von Korff M, Ciechanowski P et al (2012) Treatment adjustment and medication adherence for complex patients with diabetes, heart disease, and depression: a randomized controlled trial. Ann Fam Med 10:6–14
Lin EH, Katon W, Rutter C et al (2006) Effects of enhanced depression treatment on diabetes self-care. Ann Fam Med 4:46–53
Berkman LF, Blumenthal J, Burg M et al (2003) Effects of treating depression and low perceived social support on clinical events after myocardial infarction: the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) Randomized Trial. JAMA 289:3106–3116
Feltz-Cornelis CM van der, Nuyen J, Stoop C et al (2010) Effect of interventions for major depressive disorder and significant depressive symptoms in patients with diabetes mellitus: a systematic review and meta-analysis. Gen Hosp Psychiatry 32:380–395
Laimer M, Kramer-Reinstadler K, Rauchenzauner M et al (2006) Effect of mirtazapine treatment on body composition and metabolism. J Clin Psychiatry 67:421–424
Weber-Hamann B, Gilles M, Lederbogen F et al (2006) Improved insulin sensitivity in 80 nondiabetic patients with MDD after clinical remission in a double-blind, randomized trial of amitriptyline and paroxetine. J Clin Psychiatry 67:1856–1861
Weber-Hamann B, Gilles M, Schilling C et al (2008) Improved insulin sensitivity in 51 nondiabetic depressed inpatients remitting during antidepressive treatment with mirtazapine and venlafaxine. J Clin Psychopharmacol 28:581–584
Moosa MYH, Panz VR, Jeenah FY, Joffe BI (2003) African women with depression: the effect of imipramine and fluoxetine on body mass index and leptin secretion. J Clin Psychopharmacol 23:549–552
Chen Y-C, Lin W-W, Chen Y-J et al (2010) Antidepressant effects on insulin sensitivity and proinflammatory cytokines in the depressed males. Mediators Inflamm 2010:573594
Laimer M, Kramer-Reinstadler K, Rauchenzauner M et al (2006) Effect of mirtazapine treatment on body composition and metabolism. J Clin Psychiatry 67:421–424
Kauffman RP, Castracane VD, White DL et al (2005) Impact of the selective serotonin reuptake inhibitor citalopram on insulin sensitivity, leptin and basal cortisol secretion in depressed and non-depressed euglycemic women of reproductive age. Gynecol Endocrinol 21:129–137
Chen Y-C, Shen Y-C, Hung Y-J et al (2007) Comparisons of glucose-insulin homeostasis following maprotiline and fluoxetine treatment in depressed males. J Affect Disord 103:257–261
Pinar M, Gulsun M, Tasci I et al (2008) Maprotiline induced weight gain in depressive disorder: changes in circulating ghrelin and adiponectin levels and insulin sensitivity. Progr Neuropsychopharmacol Biol Psychiatry 32:135–139
McIntyre RS, Soczynska JK, Konarski JZ, Kennedy SH (2006) The effect of antidepressants on glucose homeostasis and insulin sensitivity: synthesis and mechanisms. Expert Opin Drug Saf 5:157–168
Knol MJ, Geerlings MI, Egberts AC et al (2007) No increased incidence of diabetes in antidepressant users. Int Clin Psychopharmacol 22:382–386
Kivimäki M, Hamer M, Pentti J et al (2010) Antidepressant medication use, weight gain, and risk of type 2 diabetes. Diabetes Care 33:2611–2616
Rubin RR, Ma Y, Marrero DG et al (2008) Elevated depression symptoms, antidepressant medicine use, and risk of developing diabetes during the diabetes prevention program. Diabetes Care 31:420–426
Andersohn F, Schade R, Suissa S, Garbe E (2009) Long-term use of antidepressants for depressive disorders and the risk of diabetes mellitus. Am J Psychiatry 166:591–598
Raeder MB, Bjelland I, Emil Vollset S, Steen VM (2006) Obesity, dyslipidemia, and diabetes with selective serotonin reuptake inhibitors: the Hordaland Health Study. J Clin Psychiatry 67:1974–1982
Derijks HJ, Meyboom RHB, Heerdink ER et al (2008) The association between antidepressant use and disturbances in glucose homeostasis: evidence from spontaneous reports. Eur J Clin Pharmacol 64:531–538
Brown LC, Majumdar SR, Johnson JA (2008) Type of antidepressant therapy and risk of type 2 diabetes in people with depression. Diabetes Res Clin Pract 79:61–67
Reedt Dortland A van, Giltay E, Veen T van et al (2010) Metabolic syndrome abnormalities are associated with severity of anxiety and depression and with tricyclic antidepressant use. Am J Psychiatry 122:30–39
Kivimäki M, Batty GD, Jokela M et al (2011) Antidepressant medication use and risk of hyperglycemia and diabetes mellitus: a noncausal association? Biol Psychiatry 70:978–984
Pyykkönen A-J, Räikkönen K, Tuomi T et al (2011) Depressive symptoms, antidepressant medication use, and insulin resistance: the PPP-Botnia Study. Diabetes Care 34:2545–2547
Lugtenberg M, Burgers JS, Clancy C et al (2011) Current guidelines have limited applicability to patients with comorbid conditions: a systematic analysis of evidence-based guidelines. PLoS One 6:e25987
De Hert M, Dekker JM, Wood D et al (2009) Cardiovascular disease and diabetes in people with severe mental illness position statement from the European Psychiatric Association (EPA), supported by the European Association for the Study of Diabetes (EASD) and the European Society of Cardiology (ESC). Eur Psychiatry 24:412–424
Kulzer B, Albus C, Herpertz S et al (2007) Psychosoziales und Diabetes mellitus. Diabetologie 2(Suppl 2):184–190
Taylor V, MacQueen G (2006) Associations between bipolar disorder and metabolic syndrome: a review. J Clin Psychiatry 67:1034–1041
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Der korrespondierende Autor weist für sich und seinen Koautor auf folgende Beziehungen hin: MD erhielt Honorare für Vorträge und Teilnahme an Advisory Boards von Otsuka Pharma und Bristol-Myers Squibb sowie Studienunterstützung von Pfizer. VS erhielt Honorare für Vorträge von AstraZeneka.
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Deuschle, M., Schweiger, U. Depression und Diabetes mellitus Typ 2. Nervenarzt 83, 1410–1422 (2012). https://doi.org/10.1007/s00115-012-3656-9
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DOI: https://doi.org/10.1007/s00115-012-3656-9