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Transcription Factor NF-κB: An Update on Intervention Strategies

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Archivum Immunologiae et Therapiae Experimentalis Aims and scope

Abstract

The nuclear factor (NF)-κB family of transcription factors are ubiquitous and pleiotropic molecules that regulate the expression of more than 150 genes involved in a broad range of processes including inflammation, immunity, cell proliferation, differentiation, and survival. The chronic activation or dysregulation of NF-κB signaling is the central cause of pathogenesis in many disease conditions and, therefore, NF-κB is a major focus of therapeutic intervention. Because of this, understanding the relationship between NF-κB and the induction of various downstream signaling molecules is imperative. In this review, we provide an updated synopsis of the role of NF-κB in DNA repair and in various ailments including cardiovascular diseases, HIV infection, asthma, herpes simplex virus infection, chronic obstructive pulmonary disease, and cancer. Furthermore, we also discuss the specific targets for selective inhibitors and future therapeutic strategies.

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Acknowledgments

We would like to thank Tania Hicks, Gagandeep Kaur and Dhirendra P. Singh from Environmental Toxicology PhD Program, Southern University and A&M College, Baton Rouge, Louisiana 70813 for critical reading of the manuscript. This work was supported by Young Clinical Scientist Award from the Flight Attendant Medical Research Institute (FAMRI- 123253_YCSA_Faculty); NIH R15 (7 R15 ES023151 02); Southern University System Foundation Grant (COSC0016) and Louisiana Biomedical Research Network (LBRN) Startup Funds 2P20GM103424-14 (Subaward No. 100011) to SB.

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Authors and Affiliations

  1. Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, 70803, USA

    Arvind Panday, Diana Osorio & Sanjay Batra

  2. Department of Biological Sciences, Louisiana State University, Baton Rouge, LA, 70803, USA

    Arvind Panday

  3. Departamento de Microbiología, CONICET, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional Rosario, Suipacha 531, Santa Fe, Argentina

    Maria Eugenia Inda

  4. Laboratory of Pulmonary Immunotoxicology, Environmental Toxicology PhD Program, 207 Health Research Center, Southern University and A&M College, Baton Rouge, LA, 70813, USA

    Prathyusha Bagam & Sanjay Batra

  5. Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94304, USA

    Malaya K. Sahoo

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  1. Arvind Panday
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  2. Maria Eugenia Inda
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Correspondence to Sanjay Batra.

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Panday, A., Inda, M.E., Bagam, P. et al. Transcription Factor NF-κB: An Update on Intervention Strategies. Arch. Immunol. Ther. Exp. 64, 463–483 (2016). https://doi.org/10.1007/s00005-016-0405-y

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