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Gepubliceerd in: Netherlands Heart Journal 3/2010

01-03-2010 | Interuniversity Cardiology Institute of the Netherlands

Fever-triggered ventricular arrhythmias in Brugada syndrome and type 2 long-QT syndrome

Auteurs: A. S. Amin, C. A. Klemens, P. G. Meregalli, A. Asghari-Roodsari, J. M. T. de Bakker, C. T. January, A. A. M. Wilde, H. L. Tan

Gepubliceerd in: Netherlands Heart Journal | Uitgave 3/2010

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Abstract

The risk for lethal ventricular arrhythmias is increased in individuals who carry mutations in genes that encode cardiac ion channels. Loss-of-function mutations in SCN5A, the gene encoding the cardiac sodium channel, are linked to Brugada syndrome (BrS). Arrhythmias in BrS are often preceded by coved-type ST-segment elevation in the right-precordial leads V1 and V2. Loss-of-function mutations in KCNH2, the gene encoding the cardiac ion channel that is responsible for the rapidly activating delayed rectifying potassium current, are linked to long-QT syndrome type 2 (LQT-2). LQT-2 is characterised by delayed cardiac repolarisation and rate-corrected QT interval (QTc) prolongation. Here, we report that the risk for ventricular arrhythmias in BrS and LQT-2 is further increased during fever. Moreover, we demonstrate that fever may aggravate coved-type ST-segment elevation in BrS, and cause QTc lengthening in LQT-2. Finally, we describe molecular mechanisms that may underlie the proarrhythmic effects of fever in BrS and LQT-2. (Neth Heart J 2010;18:165-9.)
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Metagegevens
Titel
Fever-triggered ventricular arrhythmias in Brugada syndrome and type 2 long-QT syndrome
Auteurs
A. S. Amin
C. A. Klemens
P. G. Meregalli
A. Asghari-Roodsari
J. M. T. de Bakker
C. T. January
A. A. M. Wilde
H. L. Tan
Publicatiedatum
01-03-2010
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Netherlands Heart Journal / Uitgave 3/2010
Print ISSN: 1568-5888
Elektronisch ISSN: 1876-6250
DOI
https://doi.org/10.1007/BF03091755

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