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Gepubliceerd in:

01-02-2009 | Interuniversity Cardiology Institute of the Netherlands

Ultrasound and microbubble-targeted delivery of therapeutic compounds

ICIN Report Project 49: Drug and gene delivery through ultrasound and microbubbles

Auteurs: L. J. M. Juffermans, A. van Wamel, R. H. Henning, K. Kooiman, M. Emmer, N. de Jong, W. H. van Gilst, R. Musters, W. J. Paulus, A. C. van Rossum, L. E. Deelman, O. Kamp

Gepubliceerd in: Netherlands Heart Journal | Uitgave 2/2009

Abstract

The molecular understanding of diseases has been accelerated in recent years, producing many new potential therapeutic targets. A noninvasive delivery system that can target specific anatomical sites would be a great boost for many therapies, particularly those based on manipulation of gene expression. The use of microbubbles controlled by ultrasound as a method for delivery of drugs or genes to specific tissues is promising. It has been shown by our group and others that ultrasound increases cell membrane permeability and enhances uptake of drugs and genes. One of the important mechanisms is that microbubbles act to focus ultrasound energy by lowering the threshold for ultrasound bioeffects. Therefore, clear understanding of the bioeffects and mechanisms underlying the membrane permeability in the presence of microbubbles and ultrasound is of paramount importance. (Neth Heart J 2009;17:82-6.)

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Schlicher RK, Radhakrishna H, Tolentino TP, Apkarian RP, Zarnitsyn V, et al. Mechanism of intracellular delivery by acoustic cavitation. Ultrasound Med Biol 2006;32:915-24.

Mayer CR, Bekeredjian R. Ultrasonic gene and drug delivery to the cardiovascular system. Adv Drug Deliv Rev 2008;60:1177-92.

Dijkmans PA, Juffermans LJM, Musters RJP, van Wamel A, ten Cate F, van Gilst W, et al. Microbubbles and ultrasound: from diagnosis to therapy. Eur J Echocardiography 2004;5:245-56.

Bekeredjian R, Chen S, Grayburn PA, Shohet RV. Augmentation of cardiac protein delivery using ultrasound targeted microbubble destruction. Ultrasound Med Biol 2005;31:687-91.

Tachibana K, Uchida T, Ogawa K, Yamashita N, Tamura K. Induction of cell-membrane porosity by ultrasound. Lancet 1999;353:1409.

Miller DL, Pislaru SV, Greenleaf JE. Sonoporation: mechanical DNA delivery by ultrasonic cavitation. Somat Cell Mol Genet 2002;27:115-34.

Ohl CD, Arora M, Ikink R, de Jong N, Versluis M, Delius M, et al. Sonoporation from jetting cavitation bubbles. Biophys J 2006;91:4285-95.

van Wamel A, Kooiman K, Harteveld M, Emmer M, Ten Cate FJ, Versluis M, et al. Vibrating microbubbles poking individual cells: Drug transfer into cells via sonoporation. J Control Release 2006;112:149-55.

Juffermans LJ, Dijkmans PA, Musters RJ, Visser CA, Kamp O. Transient permeabilization of cell membranes by ultrasound-exposed microbubbles is related to formation of hydrogen peroxide. Am J Physiol Heart Circ Physiol 2006;291:H1595-601.

10.

van der Wouw PA, Brauns AC, Bailey SE, Powers JE, Wilde AA. Premature ventricular contractions during triggered imaging with ultrasound contrast. J Am Soc Echocardiogr 2000;13:288-94.

11.

Li P, Armstrong WF, Miller DL. Impact of myocardial contrast echocardiography on vascular permeability: comparison of three different contrast agents. Ultrasound Med Biol 2004;30:83-91.

12.

Dijkmans PA, van Dijk J, Juffermans LJM, Musters RJP, Spreeuwenberg, Visser CA, et al. Safety and feasibility of real-time adenosine myocardial contrast echocardiography with emphasis on induction of arrhythmias: a study in healthy volunteers and patients with stable coronary artery disease. Echocardiography 2009. In press.

13.

Juffermans LJ, Kamp O, Dijkmans PA, Visser CA, Musters RJ. Lowintensity ultrasound-exposed microbubbles provoke local hyperpolarization of the cell membrane via activation of BK(Ca) channels. Ultrasound Med Biol 2008;34:502-8.

14.

Nelson MT, Cheng H, Rubart M, Santana LF, Bonev AD, Knot HJ, et al. Relaxation of arterial smooth muscle by calcium sparks. Science 1995;270:633-7.

15.

Berridge MJ, Bootman MD, Lipp P. Calcium–a life and death signal. Nature 1998;395:645-8.

16.

van Wamel A, Bouakaz A, Versluis M, de Jong N. Micromanipulation of endothelial cells: ultrasound-microbubbles-cell interaction. Ultrasound Med Biol 2004;30:1255-8.

17.

Seksek O, Biwersi J, Verkman AS. Translational diffusion of macromoleculesized solutes in cytoplasm and nucleus. J Cell Biol 1997;138:131-42.

18.

Miller DL, Quddus J. Sonoporation of monolayer cells by diagnostic ultrasound activation of contrast-agent gas bodies. Ultrasound Med Biol 2003;26:661-7.

19.

Meijering BDM, Juffermans LJM, van Wamel A, Henning RH, Zuhorn IS, Emmer M, et al. Ultrasound and microbubble-targeted delivery of macromolecules is regulated by induction of endocytosis and pore formation. Revision submitted. 2008.

20.

Meijering BDM, Henning RH, Deelman LE. Ultrasound and microbubble mediated gene therapy: effectiveness of siRNA versus plasmid DNA delivery. Submitted. 2008.

Titel: Ultrasound and microbubble-targeted delivery of therapeutic compounds
ICIN Report Project 49: Drug and gene delivery through ultrasound and microbubbles
Auteurs: L. J. M. Juffermans
A. van Wamel
R. H. Henning
K. Kooiman
M. Emmer
N. de Jong
W. H. van Gilst
R. Musters
W. J. Paulus
A. C. van Rossum
L. E. Deelman
O. Kamp
Publicatiedatum: 01-02-2009
Uitgeverij: Bohn Stafleu van Loghum
Gepubliceerd in: Netherlands Heart Journal / Uitgave 2/2009
Print ISSN: 1568-5888
Elektronisch ISSN: 1876-6250
DOI: https://doi.org/10.1007/BF03086223

Bohn Stafleu van Loghum

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