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01-03-2007 | review article

Regulation and characteristics of vascular smooth muscle cell phenotypic diversity

Auteurs: S. S. M. Rensen, P. A. F. M. Doevendans, G. J. J. M. van Eys

Gepubliceerd in: Netherlands Heart Journal | Uitgave 3/2007

Abstract

Vascular smooth muscle cells can perform both contractile and synthetic functions, which are associated with and characterised by changes in morphology, proliferation and migration rates, and the expression of different marker proteins. The resulting phenotypic diversity of smooth muscle cells appears to be a function of innate genetic programmes and environmental cues, which include biochemical factors, extracellular matrix components, and physical factors such as stretch and shear stress. Because of the diversity among smooth muscle cells, blood vessels attain the flexibility that is necessary to perform efficiently under different physiological and pathological conditions. In this review, we discuss recent literature demonstrating the extent and nature of smooth muscle cell diversity in the vascular wall and address the factors that affect smooth muscle cell phenotype. (Neth Heart J 2007;15:100-8.)

vorige artikel Haemodynamic patterns in ST-elevation myocardial infarction: incidence and correlates of elevated filling pressures

volgende artikel Isolated left ventricular noncompaction in a patient presenting with a subacute myocardial infarction

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Titel: Regulation and characteristics of vascular smooth muscle cell phenotypic diversity
Auteurs: S. S. M. Rensen
P. A. F. M. Doevendans
G. J. J. M. van Eys
Publicatiedatum: 01-03-2007
Uitgeverij: Bohn Stafleu van Loghum
Gepubliceerd in: Netherlands Heart Journal / Uitgave 3/2007
Print ISSN: 1568-5888
Elektronisch ISSN: 1876-6250
DOI: https://doi.org/10.1007/BF03085963

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