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Gepubliceerd in: Huisarts en wetenschap 7/2009

01-07-2009 | Onderzoek

Routine-ECG’s bij oudste ouderen

De toegevoegde waarde voor cardiovasculair risicomanagement

Auteurs: Wouter de Ruijter, Pim Assendelft, Peter Macfarlane, Rudi Westendorp, Jacobijn Gussekloo

Gepubliceerd in: Huisarts en wetenschap | Uitgave 7/2009

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Samenvatting

De Ruijter W, Assendelft WJJ, Macfarlane PW, Westendorp RGJ, Gussekloo J. Routine-ECG’s bij oudste ouderen. De toegevoegde waarde voor cardiovasculair risicomanagement. Huisarts Wet 2009;52(7):318-23.
Doel Wij onderzochten of het routinematig maken van ECG’s bij oudste ouderen uit de algemene populatie toegevoegde waarde heeft voor cardiovasculair risicomanagement boven op de informatie die al beschikbaar is uit het medisch dossier.
Methode In het kader van de Leiden 85-plus Studie, een prospectief-observationeel onderzoek met 566 deelnemers van 85 jaar (377 vrouwen, 189 mannen) uit de algemene populatie, verkregen we de cardiovasculaire voorgeschiedenis uit medische dossiers van huisartsen. We evalueerden baseline-ECG’s op de aanwezigheid van een oud myocardinfarct en/of atriumfibrilleren. Tijdens vijf jaar follow-up verzamelden we totale en cardiovasculaire mortaliteits- en morbiditeitsgegevens.
Resultaten Gedurende de follow-up overleden 262 van de 566 (46%) deelnemers, van wie 102 (39%) aan een cardiovasculaire aandoening. Deelnemers met een cardiovasculaire voorgeschiedenis op 85-jarige leeftijd (284/566, 50%) hadden een verhoogde cardiovasculaire mortaliteit (HR 2,7, 95%-BI 1,8-4,1) en morbiditeit (HRmyocardinfarct 2,1, 95%-BI 1,3-3,6; HRCVA 2,7, 95%-BI 1,6-4,9) in vergelijking met deelnemers zonder cardiovasculaire voorgeschiedenis. Deelnemers met belangrijke afwijkingen op het baseline-ECG (102/566, 18%) hadden een verhoogde cardiovasculaire mortaliteit (HR 1,8, 95%-BI 1,1-2,8), maar geen verhoogde cardiovasculaire morbiditeit in vergelijking met deelnemers zonder deze ECG-afwijkingen. Bij alle deelnemers, zowel met als zonder cardiovasculaire voorgeschiedenis, was de aanwezigheid van belangrijke ECG-afwijkingen niet geassocieerd met een toegenomen cardiovasculaire mortaliteit of morbiditeit.
Conclusie Bij oudste ouderen uit de algemene populatie is een cardiovasculaire voorgeschiedenis een sterke voorspeller van cardiovasculaire mortaliteit en morbiditeit. Hoewel abnormale bevindingen op routine-ECG’s bij deze ouderen cardiovasculaire mortaliteit voorspellen, voegt dit geen prognostische informatie toe aan de reeds beschikbare informatie uit medische dossiers. Als goed bijgehouden medische dossiers beschikbaar zijn, is het niet effectief om programmatisch ECG’s bij oudste ouderen te maken.
Literatuur
1.
go back to reference Strandberg TE, Pitkala KH, Berglind S, Nieminen MS, Tilvis RS. Multifactorial intervention to prevent recurrent cardiovascular events in patients 75 years or older: The Drugs and Evidence-Based Medicine in the Elderly (DEBATE) study: A randomized, controlled trial. Am Heart J 2006;152:585-92. Strandberg TE, Pitkala KH, Berglind S, Nieminen MS, Tilvis RS. Multifactorial intervention to prevent recurrent cardiovascular events in patients 75 years or older: The Drugs and Evidence-Based Medicine in the Elderly (DEBATE) study: A randomized, controlled trial. Am Heart J 2006;152:585-92.
2.
go back to reference Antithrombotic Trialists’ Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 2002;324:71-86. Antithrombotic Trialists’ Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 2002;324:71-86.
3.
go back to reference Bulpitt CJ. Secondary prevention of coronary heart disease in the elderly. Heart 2005;91:396-400. Bulpitt CJ. Secondary prevention of coronary heart disease in the elderly. Heart 2005;91:396-400.
4.
go back to reference Fox KM, Bertrand M, Ferrari R, Remme WJ, Simoons ML, Remme WJ, et al. Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: Randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). Lancet 2003;362:782-8. Fox KM, Bertrand M, Ferrari R, Remme WJ, Simoons ML, Remme WJ, et al. Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: Randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). Lancet 2003;362:782-8.
5.
go back to reference Gottlieb SS, McCarter RJ, Vogel RA. Effect of beta-blockade on mortality among high-risk and low-risk patients after myocardial infarction. N Engl J Med 1998;339:489-97. Gottlieb SS, McCarter RJ, Vogel RA. Effect of beta-blockade on mortality among high-risk and low-risk patients after myocardial infarction. N Engl J Med 1998;339:489-97.
6.
go back to reference Gotto AM, Jr. Statin Therapy and the Elderly: SAGE Advice? Circulation 2007;115:681-3. Gotto AM, Jr. Statin Therapy and the Elderly: SAGE Advice? Circulation 2007;115:681-3.
7.
go back to reference Hunt D, Young P, Simes J, Hague W, Mann S, Owensby D, et al. Benefits of pravastatin on cardiovascular events and mortality in older patients with coronary heart disease are equal to or exceed those seen in younger patients: Results from the LIPID trial. Ann Intern Med 2001;134:931-40. Hunt D, Young P, Simes J, Hague W, Mann S, Owensby D, et al. Benefits of pravastatin on cardiovascular events and mortality in older patients with coronary heart disease are equal to or exceed those seen in younger patients: Results from the LIPID trial. Ann Intern Med 2001;134:931-40.
8.
go back to reference Shepherd J, Blauw GJ, Murphy MB, Bollen ELEM, Buckley BM, Cobbe SM, et al. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): A randomised controlled trial. Lancet 2002;360:1623-30. Shepherd J, Blauw GJ, Murphy MB, Bollen ELEM, Buckley BM, Cobbe SM, et al. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): A randomised controlled trial. Lancet 2002;360:1623-30.
9.
go back to reference Wei L, Ebrahim S, Bartlett C, Davey PD, Sullivan FM, MacDonald TM. Statin use in the secondary prevention of coronary heart disease in primary care: cohort study and comparison of inclusion and outcome with patients in randomised trials. BMJ 2005;330:821. Wei L, Ebrahim S, Bartlett C, Davey PD, Sullivan FM, MacDonald TM. Statin use in the secondary prevention of coronary heart disease in primary care: cohort study and comparison of inclusion and outcome with patients in randomised trials. BMJ 2005;330:821.
10.
go back to reference Clinical Guideline A. Prophylaxis for patients who have experienced a myocardial infarction. London, UK: National Institute for Clinical Excellence, 2006. Clinical Guideline A. Prophylaxis for patients who have experienced a myocardial infarction. London, UK: National Institute for Clinical Excellence, 2006.
11.
go back to reference De Backer G, Ambrosioni E, Borch-Johnsen K, Brotons C, Cifkova R, Dallongeville J, et al. European guidelines on cardiovascular disease prevention in clinical practice – Third Joint Task Force of European and other Societies on Cardiovascular Disease Prevention in Clinical Practice. Eur Heart J 2003;24:1601-10. De Backer G, Ambrosioni E, Borch-Johnsen K, Brotons C, Cifkova R, Dallongeville J, et al. European guidelines on cardiovascular disease prevention in clinical practice – Third Joint Task Force of European and other Societies on Cardiovascular Disease Prevention in Clinical Practice. Eur Heart J 2003;24:1601-10.
12.
go back to reference Fuster V, Ryden LE, Cannom DS, Crijns HJ, Curtis AB, Ellenbogen KA, et al. ACC/AHA/ESC 2006 Guidelines for the management of patients with atrial fibrillation: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to revise the 2001 Guidelines for the management of patients with atrial fibrillation): Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Circulation 2006;114:e257-e354. Fuster V, Ryden LE, Cannom DS, Crijns HJ, Curtis AB, Ellenbogen KA, et al. ACC/AHA/ESC 2006 Guidelines for the management of patients with atrial fibrillation: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to revise the 2001 Guidelines for the management of patients with atrial fibrillation): Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Circulation 2006;114:e257-e354.
13.
go back to reference Smith SC, Allen J, Blair SN, Bonow RO, Brass LM, Fonarow GC, et al. AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update – Endorsed by the National Heart, Lung, and Blood Institute. Circulation 2006;113:2363-72. Smith SC, Allen J, Blair SN, Bonow RO, Brass LM, Fonarow GC, et al. AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update – Endorsed by the National Heart, Lung, and Blood Institute. Circulation 2006;113:2363-72.
14.
go back to reference Williams MA, Fleg JL, Ades PA, Chaitman BR, Miller NH, Mohiuddin SM, et al. Secondary prevention of coronary heart disease in the elderly (with emphasis on patients ≥ 75 years of age): An American Heart Association Scientific Statement from the Council on Clinical Cardiology Subcommittee on Exercise, Cardiac Rehabilitation, and Prevention. Circulation 2002;105:1735-43. Williams MA, Fleg JL, Ades PA, Chaitman BR, Miller NH, Mohiuddin SM, et al. Secondary prevention of coronary heart disease in the elderly (with emphasis on patients ≥ 75 years of age): An American Heart Association Scientific Statement from the Council on Clinical Cardiology Subcommittee on Exercise, Cardiac Rehabilitation, and Prevention. Circulation 2002;105:1735-43.
15.
go back to reference De Ruijter W, Westendorp RGJ, Macfarlane PW, Jukema JW, Assendelft WJJ, Gussekloo J. The routine electrocardiogram for cardiovascular risk stratification in old age: The Leiden 85-Plus Study. J Am Geriatr Soc 2007;55:872-7. De Ruijter W, Westendorp RGJ, Macfarlane PW, Jukema JW, Assendelft WJJ, Gussekloo J. The routine electrocardiogram for cardiovascular risk stratification in old age: The Leiden 85-Plus Study. J Am Geriatr Soc 2007;55:872-7.
16.
go back to reference Nadelmann J, Frishman WH, Ooi WL, Tepper D, Greenberg S, Guzik H, et al. Prevalence, incidence and prognosis of recognized and unrecognized myocardial infarction in persons aged 75 years or older: The Bronx Aging Study. Am J Cardiol 1990;66:533-7. Nadelmann J, Frishman WH, Ooi WL, Tepper D, Greenberg S, Guzik H, et al. Prevalence, incidence and prognosis of recognized and unrecognized myocardial infarction in persons aged 75 years or older: The Bronx Aging Study. Am J Cardiol 1990;66:533-7.
17.
go back to reference Sheifer SE, Gersh BJ, Yanez ND, III, Ades PA, Burke GL, Manolio TA. Prevalence, predisposing factors, and prognosis of clinically unrecognized myocardial infarction in the elderly. J Am Coll Cardiol 2000;35:119-26. Sheifer SE, Gersh BJ, Yanez ND, III, Ades PA, Burke GL, Manolio TA. Prevalence, predisposing factors, and prognosis of clinically unrecognized myocardial infarction in the elderly. J Am Coll Cardiol 2000;35:119-26.
18.
go back to reference Macfarlane PW, Latif S. Automated serial ECG comparison based on the Minnesota code. J Electrocardiol 1996;29 Suppl:29-34. Macfarlane PW, Latif S. Automated serial ECG comparison based on the Minnesota code. J Electrocardiol 1996;29 Suppl:29-34.
19.
go back to reference Prineas RJ, Crow RS, Blackburn H. The Minnesota code manual of electrocardiographic findings: standards and procedures for measurement and classification. Boston, USA: Wright, 1982. Prineas RJ, Crow RS, Blackburn H. The Minnesota code manual of electrocardiographic findings: standards and procedures for measurement and classification. Boston, USA: Wright, 1982.
20.
go back to reference International Statistical Classification of diseases and Related Health Problems, 10th revision. Geneva, Switzerland: World Health Organization, 1992. International Statistical Classification of diseases and Related Health Problems, 10th revision. Geneva, Switzerland: World Health Organization, 1992.
21.
go back to reference Mitka M. Electronic Health Records, After-Hours Care Lag in US Primary Care Practices. JAMA 2006;296:2913-14. Mitka M. Electronic Health Records, After-Hours Care Lag in US Primary Care Practices. JAMA 2006;296:2913-14.
22.
go back to reference Benjamin EJ, Wolf PA, D’Agostino RB, Silbershatz H, Kannel WB, Levy D. Impact of atrial fibrillation on the risk of death. Circulation 1998;98:946-52. Benjamin EJ, Wolf PA, D’Agostino RB, Silbershatz H, Kannel WB, Levy D. Impact of atrial fibrillation on the risk of death. Circulation 1998;98:946-52.
23.
go back to reference Sheifer SE, Manolio TA, Gersh BJ. Unrecognized myocardial infarction. Ann Intern Med 2001;135:801-11. Sheifer SE, Manolio TA, Gersh BJ. Unrecognized myocardial infarction. Ann Intern Med 2001;135:801-11.
24.
go back to reference Wolf PA, Abbott RD, Kannel WB. Atrial-fibrillation as an independent risk factor for stroke – the Framingham-Study. Stroke 1991;22:983-8. Wolf PA, Abbott RD, Kannel WB. Atrial-fibrillation as an independent risk factor for stroke – the Framingham-Study. Stroke 1991;22:983-8.
25.
go back to reference O’Donnell CJ, Glynn RJ, Field TS, Averback R, Satterfield S, Friesenger GC, et al. Misclassification and under-reporting of acute myocardial infarction by elderly persons: implications for community-based observational studies and clinical trials. J Clin Epidemiol 1999;52:745-51. O’Donnell CJ, Glynn RJ, Field TS, Averback R, Satterfield S, Friesenger GC, et al. Misclassification and under-reporting of acute myocardial infarction by elderly persons: implications for community-based observational studies and clinical trials. J Clin Epidemiol 1999;52:745-51.
26.
go back to reference Kors JA, Van Herpen G, Wu J, Zhang Z, Prineas RJ, Van Bemmel JH. Validation of a new computer program for Minnesota coding. J Electrocardiol 1996;29 Suppl:83-8. Kors JA, Van Herpen G, Wu J, Zhang Z, Prineas RJ, Van Bemmel JH. Validation of a new computer program for Minnesota coding. J Electrocardiol 1996;29 Suppl:83-8.
27.
go back to reference Tuinstra CL, Rautaharju PM, Prineas RJ, Duisterhout JS. The performance of three visual coding procedures and three computer programs in classification of electrocardiograms according to the Minnesota Code. J Electrocardiol 1982;15:345-50. Tuinstra CL, Rautaharju PM, Prineas RJ, Duisterhout JS. The performance of three visual coding procedures and three computer programs in classification of electrocardiograms according to the Minnesota Code. J Electrocardiol 1982;15:345-50.
28.
go back to reference Ramsay SE, Whincup PH, Lawlor DA, Papacosta O, Lennon LT, Thomas MC, et al. Secondary prevention of coronary heart disease in older patients after the national service framework: population based study. BMJ 2006;332:144-5. Ramsay SE, Whincup PH, Lawlor DA, Papacosta O, Lennon LT, Thomas MC, et al. Secondary prevention of coronary heart disease in older patients after the national service framework: population based study. BMJ 2006;332:144-5.
29.
go back to reference Sudlow M, Rodgers H, Kenny RA, Thomson R. Population based study of use of anticoagulants among patients with atrial fibrillation in the community. BMJ 1997;314:1529-30. Sudlow M, Rodgers H, Kenny RA, Thomson R. Population based study of use of anticoagulants among patients with atrial fibrillation in the community. BMJ 1997;314:1529-30.
30.
go back to reference Tran CTT, Laupacis A, Mamdani MM, Tu JV. Effect of age on the use of evidence-based therapies for acute myocardial infarction. Am Heart J 2004;148:834-41. Tran CTT, Laupacis A, Mamdani MM, Tu JV. Effect of age on the use of evidence-based therapies for acute myocardial infarction. Am Heart J 2004;148:834-41.
Metagegevens
Titel
Routine-ECG’s bij oudste ouderen
De toegevoegde waarde voor cardiovasculair risicomanagement
Auteurs
Wouter de Ruijter
Pim Assendelft
Peter Macfarlane
Rudi Westendorp
Jacobijn Gussekloo
Publicatiedatum
01-07-2009
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Huisarts en wetenschap / Uitgave 7/2009
Print ISSN: 0018-7070
Elektronisch ISSN: 1876-5912
DOI
https://doi.org/10.1007/BF03085666

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