Skip to main content
Log in

Towards a universal approach for screening of retinopathy of prematurity (ROP)

  • Published:
Documenta Ophthalmologica Aims and scope Submit manuscript

Abstract

To improve the cost-benefit ratio of our current screening program for retinopathy of prematurity (ROP), the records of 312 infants who had been screened for ROP were studied retrospectively. Using a safety-index containing three well known risk factors (birthweight, gestational age, oxygen use), infants were classified to be at high risk or low risk for the development of ROP. When all high risk infants would have been screened extensively from the 5th postnatal week onwards and all low risk infants would have been screened once at the 7th postnatal week, a 9.8% reduction of ophthalmological examinations would have been obtained at the expense of missing 2.9% of non vision threatening ROP.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Cryotherapy for Retinopathy of Prematurity Cooperative Group. Multicenter trial of cryotherapy for retinopathy of prematurity: one year outcome—structure and function. Arch Ophthalmol 1990; 108: 1408–1416.

    Google Scholar 

  2. Holmstrom G, El Azazi M, Jacobson L, Sachs D, Sule J, Lennerstrand G. Epidemiology of ROP in the Stockholm area of Sweden. Acta Ophthalmol 1993; 71 suppl 210: 44–47.

    Google Scholar 

  3. Jacobson L, Stenstrom I. Visually impairing ROP in children born in Sweden 1975–89. Acta Ophthalmol 1993; 71 suppl 210: 16–19.

    Google Scholar 

  4. Bech N, Fledelius H, Rosenberg T. Retinopathy of prematurity 1974–91. An analysis of the Danish register for the visually impaired. Acta Ophthalmol 1993; 71 suppl 210: 12–15.

    Google Scholar 

  5. Fledelius HC, Rosenberg T. Retinopathy of prematurity. Where to set screening limits? Acta Paediatr Scand 1990; 79: 906–910.

    PubMed  CAS  Google Scholar 

  6. Fielder AR, Levene MI. Screening for retinopathy of prematurity. Arch Dis Child 1992; 67: 860–867.

    PubMed  CAS  Google Scholar 

  7. Schulenburg WE, Prendiville A, Ohri R. Natural history of retinopathy of prematurity. Br J Ophthalmol 1987; 71: 837–843.

    PubMed  CAS  Google Scholar 

  8. Stannard KP, Mushin AS, Gamsu HR. Screening for retinopathy of prematurity in a regional neonatal intensive care unit. Eye 1989; 3: 371–378.

    PubMed  Google Scholar 

  9. Cats BP, Tan KEWP. Retinopathy of prematurity: review of a four-year period. Br J Ophthalmol 1985; 69: 500–503.

    PubMed  CAS  Google Scholar 

  10. Meier-Gibbons F, Körner F, Vogelberg Böhnke, K. The safety index and its significance for the selection of premature infants with a low risk for ROP. Invest Ophthalmol Vis Sci 1992; 33/4 suppl: 1281.

    Google Scholar 

  11. Flynn JT, Sola A, Good WV, Phibbs RH. Screening for retinopathy of prematurity—a problem solved? Pediatrics 1995; 95: 755–757

    PubMed  CAS  Google Scholar 

  12. Palmer EA, Flynn JT, Hardy RJ, Phelps DL, Phillips CL, Schaffer DB et al. The Cryotherapy for Retinopathy of Prematurity Cooperative Group. Incidence and early course of Retinopathy of Prematurity. Ophthalmol 1991; 98: 1628–1640

    CAS  Google Scholar 

  13. Fielder AR, Ng YK, Levene MI. Retinopathy of prematurity: age at onset. Arch Dis Child 1986; 61: 774–778

    PubMed  CAS  Google Scholar 

  14. Palmer EA. Optimal timing of examination for acute retrolental fibroplasia. Ophthalmology 1981; 88: 662–668

    PubMed  CAS  Google Scholar 

  15. Flynn JT, Bancalari E, Bachynski BN, Buckley EB, Bawol R, Goldberg R et al. Retinopathy of prematurity. Diagnosis, severity and natural history. Ophthalmol, 1987; 94: 620–629

    CAS  Google Scholar 

  16. Brown DR, Biglan AW, Stretabsky MAM. Screening criteria for the detection of retinopathy of prematurity in patients in a neonatal intensive care unit. J Pediatr Ophthalmol Strabismus 1987; 24: 213–214

    Google Scholar 

  17. Schalij-Delfos NE, Zijlmans BLM, Wittebol-Post D, Tan KEWP, Cats BP. Screening for Retinopathy of Prematurity: do former guidelines still apply. J Pediatr Ophthalmol Strabismus 1996; 33: 35–38

    PubMed  CAS  Google Scholar 

  18. Darlow BA, Clemett RS. Retinopathy of prematurity: screening and optimal use of the ophthalmologist's time. Aust N Z J Ophthalmol 1990 18(1): 41–46

    PubMed  CAS  Google Scholar 

  19. Javitt J, Dei Cas R, Chiang Y. Cost- effectiveness of screening and cryotherapy for threshold retinopathy of prematurity. Pediatrics 1993; 91(5): 859–866

    PubMed  CAS  Google Scholar 

  20. Cooke RWI. Annual audit of three year outcome in very low birthweight infants. Arch Dis Child 1993; 69: 295–298

    PubMed  CAS  Google Scholar 

  21. Gibson DL, Sheps SB, Hong Uh S, Schechter MT, McCormick AQ. Retinopathy of prematurity-induced blindness: birth weight-specific survival and the new epidemic. Pediatrics 1990; 86: 405–412

    PubMed  CAS  Google Scholar 

  22. Jakobi P, Weissman A, Paldi E. The extremely low birthweight infant: the twenty-first century dilemma. Am J Perinatol 1993; 10: 155–159

    Article  PubMed  CAS  Google Scholar 

  23. Cats BP, Tan KEWP. Optimal strategy for ROP screening. In BenEzra D, Ryan SJ, Glaser BM, Murphy RP eds Ocular circulation and neovascularisation. Martinus Nijhoff/Dr W Junk Publishers 1987; 50: 135–139.

  24. Committee for the Classification of Retinopathy of Prematurity. An international Classification of retinopathy of prematurity. Arch ophthalmol 1984; 102: 1130–1134

    Google Scholar 

  25. Cryotherapy for Retinopathy of Prematurity Cooperative Group. Multicenter trial of cryotherapy for retinopathy of prematurity: three month outcome. Arch Ophthalmol 1990; 108: 195–204

    Google Scholar 

  26. Fledelius HC. Retinopathy of Prematurity. Final discussion on general and Nordic aspects. Acta Ophthalmol 1993; 71 suppl 210: 79–83

    Google Scholar 

  27. Cats BP, Tan KEWP. Unexpected occurence of retinopathy of prematurity: is there a need for custom-made screening procedures? Act Ped Scand 1987; 76: 751–753.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schalij-Delfos, N.E., Zijlmans, B.L.M. & Cats, B.P. Towards a universal approach for screening of retinopathy of prematurity (ROP). Doc Ophthalmol 92, 137–144 (1996). https://doi.org/10.1007/BF02583285

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02583285

Key words

Navigation