Abstract
One year old mice from a long-lived strain were gradually subjected to life-prolonging dietary restriction. Serum immune complex and immunoglobulin G (abbreviated IgG) levels were measured at 13 and 23 months of age. Longitudinal and cross-sectional analyses showed reduced serum immune complex and IgG levels for mice underfed in adulthood.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Barrows, C. H., Jr., and Kokkonen, G. C.: Diet and life extension in animal model systems. Age, 1: 130–142, 1978.
Masoro, E. J., Bertrand, H., Liepa, G., and Yu, B. P.: Analysis and exploration of age-related changes in mammalian structure and function. Fed. Proc., 38:1956–1961, 1979.
Weindruch, R. H., Kristie, J. A., Cheney, K. E., and Walford, R. L.: Influence of controlled dietary restriction on immunologic function and aging. Fed. Proc., 38:2007–2016, 1979.
Weindruch, R., and Walford, R. L.: Dietary restriction in mice beginning at 1 year of age: effects on lifespan and spontaneous cancer incidence. Science, 215:1415–1418, 1982.
Weindruch, R., Gottesman, S. R. S., and Walford, R. L.: Modification of age-related immune decline in mice dietarily restricted from or after midadulthood. Proc. Natl. Acad. Sci. USA, 79:898–902, 1982.
Rosenthal, M.: Age and immunity. III. Circulating immune complexes in different age groups. Blut, 37: 271–274.
Delespesse, G., Gausset, P. H., Sarafati, M., Dubi-Rucquoy, M., Debisschop, M. J., and Van Haelst, L.: Circulating immune complexes in old people and in diabetics: correlation with autoantibodies. Clin. Exp. Immunol., 40:96–102, 1980.
Andrews, B. S., Eisenberg, R. A., Theofilopoulos, A. N., Izui, S., Wilson, C. B., Mc-Conahey, P. J., Murphy, E. D., Roths, J. B., and Dixon, F. J.: Spontaneous murine lupus like syndromes. Clinical and immunopathological manifestations in several strains. J. Exp. Med., 148:1198–1215, 1978.
Linder, E., Pasternack, A., and Edgington, T. S.: Pathology and immunology of age-associated disease of mice and evidence for an autoiogous immune complex pathogenesis of the associated renal disease. Clin. Immunol. Immunopathol., 1:140–154, 1972.
Theofilapoulos, A. N., and Dixon, F. J.: Immune complexes in human diseases. Am. J. Path., 100: 531–591, 1980.
Safai-Kutti, S., Fernandes, G., Wang, Y., Safai, B., Good, R. A., and Day, N. K.: Reduction of circulating immune complexes by calorie restriction in (NZB x NZW) F1 mice. Clin. Immunol. Immunopathol., 293–300, 1980.
Friend, P. S., Fernandes, G., Good, R. A., Michael, A. F., and Yunis, E. J.: Dietary restrictions early and late. Effects on the nephropathy of the NZB x NZW mouse. Lab. Invest., 38:629–632, 1978.
Barnett, E. V., Chia, D., Knutson, D., Van Lancker, J., Cheney, K., Weindruch, R., and Walford, R. L.: SLE, an accelerated form of aging, in Immunological Aspects of Aging, edited by Segre, D. and Smith, L., New York, M. Dekker, 1981, pp. 467–474.
Chia, D., Barnett, E. V., Yamagata, J., Knutson, D., Restivo, C., and Furst, D.: Quanitation and characterization of soluble immune complexes precipitated from sera by polyethylene glycol (PEG). Clin. Exp. Immunol., 37:399–407, 1979.
Author information
Authors and Affiliations
About this article
Cite this article
Weindruch, R., Chia, D., Barnett, E.V. et al. Dietary restriction in mice beginning at 1 year of age: Effects on serum immune complex levels. AGE 5, 111–112 (1982). https://doi.org/10.1007/BF02431272
Issue Date:
DOI: https://doi.org/10.1007/BF02431272