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Brainstem and middle latency auditory evoked potentials in autism and developmental language disorder

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Abstract

Brainstem auditory evoked potentials (BAEP) and middle latency responses (MLR) were studied in 8 nonretarded subjects with infantile autism (mean age=23.3,SD=2.8), 8 subjects with receptive developmental language disorder (mean age=16.3,SD=1.4), and normal control subjects matched to each group for age, gender, and Performance IQ. Click stimuli were delivered monaurally to the left and the right ear and binaurally for both the BAEPs (70-dB HL, 7/sec) and the MLRs (60-dB HL, 13/sec). Amplitudes and latencies (Waves I to VI), interwave latencies (III–V, I–V, and I–III), and Wave I/V amplitude ratio of the BAEPs were determined for each group. For the MLR study, Wave Na, Pa, and Nb latencies, and Wave Na−Pa and Pa−Nb amplitudes were calculated. There were no consistent differences in the BAEP and MLR characteristics of the control and the experimental groups. These results suggest that the abnormal cognitive processes indexed by the cognitive and attention-related event-related potential components in infantile autism and receptive developmental language disorder are not due to abnormal sensory processing in the brainstem and in areas central to the brainstem whose activity generates the BAEPs and MLRs.

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Author notes

  1. Christian Grillon

    Present address: Department of Psychiatry, GERU, Yale University School of Medicine, 40 Temple Street, 06510-3223, New Haven, Connecticut

Authors and Affiliations

  1. Department of Psyhiatry (T-004), School of Medicine, University of California, San Diego, La Jolla

    Christian Grillon & Natacha Akshoomoff

  2. Neuropsychology Research Laboratory, Children's Hospital Research Center, 8001 Frost Street, 92123, San Diego, California

    Christian Grillon, Eric Courchesne & Natacha Akshoomoff

  3. Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla

    Eric Courchesne

  4. San Diego State University, San Diego, USA

    Natacha Akshoomoff

Authors
  1. Christian Grillon
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  2. Eric Courchesne
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  3. Natacha Akshoomoff
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Additional information

The authors thank Jamie Costello who facilitated the use of the evoked potentials equipment at the Speech, Hearing and Neurosensory Center, Children's Hopsital, San Diego. The research reported was supported, in part, by National Institute of Mental Health grant 1-R01-MH36840 and NINCDS grant 5-R01-NS19855 awarded to Eric Courchesne.

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Grillon, C., Courchesne, E. & Akshoomoff, N. Brainstem and middle latency auditory evoked potentials in autism and developmental language disorder. J Autism Dev Disord 19, 255–269 (1989). https://doi.org/10.1007/BF02211845

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