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The neuropsychology of depression and its implications for cognitive therapy

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Abstract

The past few years have witnessed a growing interest in the specialty of neuropsychology as well as continued support for cognitive therapy of depression. The purpose of this paper is the examination of the neuropsychology of depression and its implications for A. T. Beck's cognitive theory and therapy of depression ([1963] “Thinking and Depression: Idiosyncratic Content and Cognitive Distortions,”Archives of General Psychiatry, Vol. 9, pp. 324–333; [1964] “Thinking and Depression,”Archives of General Psychiatry, Vol. 10, pp. 561–571; [1967]Depression: Clinical, Experimental, and Theoretical Aspects, New York: Harper & Row). Specifically, the neuropsychological and cognitive theory and therapy literatures related to depression are reviewed followed by an antegration of these areas. Neuropsychological evidence is presented that both supports cognitive theory and therapy of depression and helps explain why such therapy may prove ineffective in treating depression. Implications for clinical practice, including neuropsychological assessment of depressives, and potential future research directions are also provided.

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References

  • Abrams, R., and Taylor, M. A. (1987). Cognitive dysfunction in melancholia.Psychological Medicine 17:359–362.

    PubMed  Google Scholar 

  • Ahern, G. L., and Schwartz, G. E. (1985). Differential lateralization for positive and negative emotion in the human brain: EEG spectral analysis.Neuropsychologia 23:745–755.

    PubMed  Google Scholar 

  • Anastasi, A. (1982).Psychological Testing (5th ed.), Macmillan, New York.

    Google Scholar 

  • Baxter, L. R., Jr., Phelps, M. E., Mazziotta, J. C., Schwartz, J. M., Gerner, R. H., Selin, C. E., and Sumida, R. M. (1985). Cerebral metabolic rates for glucose in mood disorders.Archives of General Psychiatry 42:441–447.

    PubMed  Google Scholar 

  • Baxter, L. R., Jr., Schwartz, J. M., Phelps, M. E., Mazziotta, J. C., Guze, B. H., Selin, C. E., Gerner, R. H., and Sumida, R. M. (1989). Reduction of prefrontal cortex glucose metabolism common to three types of depression.Archives of General Psychiatry 46:243–250.

    PubMed  Google Scholar 

  • Beck, A. T. (1963). Thinking and depression: ldiosyncratic content and cognitive distortions.Archives of General Psychiatry 9:324–333.

    Google Scholar 

  • Beck, A. T. (1964). Thinking and depression.Archives of General Psychiatry 10:561–571.

    PubMed  Google Scholar 

  • Beck, A. T. (1967).Depression: Clinical, Experimental, and Theoretical Aspect, Harper and Row, New York.

    Google Scholar 

  • Beck, A. T. (1976).Cognitive Therapy of the Emotional Disorders, International Universities Press, New York.

    Google Scholar 

  • Beck, A. T. (1987). Cognitive models of depression.Journal of Cognitive Psychotherapy An International Quarterly 1:5–37.

    Google Scholar 

  • Beck, A. T. (1991). Cognitive therapy: A 30-year retrospective.American Psychologist 46:368–375.

    PubMed  Google Scholar 

  • Beck, A. T., and Clark, D. A. (1988). Anxiety and depression: An information processing perspective.Anxiety Research 1:23–36.

    Google Scholar 

  • Beck, A. T., Epstein, N., and Harrison, R. (1983). Cognitions, attitudes and personality dimensions in depression.British Journal of Cognitive Psychotherapy 1:1–16.

    Google Scholar 

  • Beck, A. T., Rush, A. J., Shaw, B. F., and Emery, G. (1979).Cognitive Therapy of Depression, Guilford Press, New York.

    Google Scholar 

  • Beckham, E. E. (1989). Improvement after evaluation in psychotherapy of depression: Evidence of a placebo effect?Journal of Clinical Psychology 45:945–950.

    PubMed  Google Scholar 

  • Bench, C. J., Friston, K. J., Brown, R. G., Scott, L. C., Frackowiak, R. S. J., and Dolan, R. J. (1992). The anatomy of melancholia—Focal abnormalities of cerebral blood flow in major depression.Psychological Medicine 22:607–615.

    PubMed  Google Scholar 

  • Berent, S. (1981). Lateralization of brain function. In Filskov, S. B., and Boll, T. J. (Eds.),Handbook of Clinical Neuropsychology, John Wiley and Sons, New York, pp. 74–101.

    Google Scholar 

  • Bigler, E. D. (1988).Diagnostic Clinical Neuropsychology (rev. ed.), University of Texas Pres, Austin.

    Google Scholar 

  • Blackburn, I. M., and Eunson, K. M. (1989). A content analysis of thoughts and emotions clicited from depressed patients during cognitive therapy.British Journal of Medical Psychology 62:23–33.

    PubMed  Google Scholar 

  • Bloom, R. L., Borod, J. C., Obler, L. K., and Koff, E. (1990). A preliminary characterization of lexical emotional expression in right and left brain-damaged patients.International Journal of Neuroscience 55:71–80.

    PubMed  Google Scholar 

  • Bloom, R. L., Borod, J. C., Obler, L. K., and Gerstman, L. J. (1992). Impact of emotional content on discourse production in patients with unilateral brain damage.Brain and Language 42:153–164.

    PubMed  Google Scholar 

  • Borod, J. C., Koff, E., and White, B. (1983). Facial asymmetry in posed and spontaneous expressions of emotion.Brain and Cognition 2:165–175.

    PubMed  Google Scholar 

  • Borod, J. C., Koff, E., Lorch, M. P., and Nicholas, M. (1986). The expression and perception of facial emotion in brain-damaged patients.Neuropsychologia 24:169–180.

    PubMed  Google Scholar 

  • Borod, J. C., Kent, J., Koff, E., Martin, C., and Alpert M. (1988). Facial asymmetry while posing positive and negative emotions: Support for the right hemisphere hypothesis.Neuropsychologia 26:759–764.

    PubMed  Google Scholar 

  • Borod, J. C., Andelman, F., Obler, L. K., Tweedy, J. R., and Welkowitz, J. (1992). Right hemisphere specialization for the identification of emotional words and sentences: Evidence from stroke patients.Neuropsychologia 30:827–844.

    PubMed  Google Scholar 

  • Braff, D. L., and Beck, A. T. (1974). Thinking disorder in depression.Archives of General Psychiatry 31:456–459.

    PubMed  Google Scholar 

  • Breslow, R., Kocsis, J., and Belkin, B. (1980). Memory deficits in depression: Evidence utilizing the Wechsler Memory Scale.Perceptual and Motor Skills 51:541–542.

    PubMed  Google Scholar 

  • Bruder, G. E., Quitkin, F. M., Stewart, J. W., Martin, C., Voglmaier, M. M., and Harrison, W. M. (1989). Cerebral laterality and depression: Differences in perceptual asymmetry among diagnostic subtypes.Journal of Abnormal Psychology 98:177–186.

    PubMed  Google Scholar 

  • Bryden, M. P. (1982). Laterality:Functional Asymmetry in the Intact Brain, Academic Press, New York.

    Google Scholar 

  • Cassens, G., Wolfe, L., and Zola, M. (1990). The neuropsychology of depressions.The Journal of Neuropsychiatry and Clinical Neurosciences 2:202–213.

    PubMed  Google Scholar 

  • Clark, D. A., Beck, A. T. and Brown, G. (1989). Cognitive mediation in general psychiatric outpatients: A test of the content specificity hypothesis.Journal of Personality and Social Psychology 56:958–964.

    PubMed  Google Scholar 

  • Clark, D. A., Beck, A. T., and Stewart, B. (1990). Cognitive specificity and positive-negative affectivity: Complementary or contradictory views on anxiety and depression?Journal of Abnormal Psychology 99:148–155.

    PubMed  Google Scholar 

  • Coffey, C. E. (1987). Cerebral laterality and emotion: The neurology of depression.Comprehensive Psychiatry 28:197–219.

    PubMed  Google Scholar 

  • Cohen, R. M., Weingartner, H., Smallberg, S. A., Pickar, D., and Murphy, D. L. (1982). Effort and cognition in depression.Archives of General Psychiatry 39:593–597.

    PubMed  Google Scholar 

  • Crews, W. D., Jr., and Harrison, D. W. (1992). Cerebral asymmetry in facial affect perception of women: Neuropsychological effects of depression. Unpublished master's thesis, Virginia Polytechnic Institute and State University, Blacksburg, VA.

    Google Scholar 

  • Davidson, R. J. (1984). Affect, cognition and hemispheric specialization. In Izard, C. E., Kagan, J., and Zajonic, R. (Eds.),Emotion, Cognition and Behavior, pp. 320–365.

  • Davidson, R. J. (1992). Anterior asymmetry, affective style and depression.Psychophysiology 29:S4.

    Google Scholar 

  • Davidson, R. J., and Fox, N. A. (1988). Cerebral asymmetry and emotion: Developmental and individual differences. In Molfese, D. L., and Segalowitz, S. J. (Eds.)Brain Lateralization in Children: Developmental Considerations, The Guiford Press, New York.

    Google Scholar 

  • Davidson, R. J., Chapman, J. P., and Chapman, L. J. (1987). Task-dependent EEG asymmetry discriminates between depressed and nondepressed subjects.Psychophysiology 24:585.

    Google Scholar 

  • Davidson, R. J., Schwartz, G. E., Saron, C., Bennett, J., and Goleman, D. (1979), Frontal versus parietal asymmetry during positive and negative affect.Psychophysiology 16:202–203.

    Google Scholar 

  • Davidson, R. J., Ekman, P., Saron, C. D., Senulis, J. A., and Friesen, W. V. (1990). Approach-withdrawal and cerebral asymmetry: Emotional expression and brain physiology I.Journal of Personality and Social Psychology 58:330–341.

    PubMed  Google Scholar 

  • Dean, R. S., Gray, J. W., and Seretny, M. L. (1987). Cognitive aspects of schizophrenia and primary affective depression.The International Journal of Clinical Neuropsychology 9:33–36.

    Google Scholar 

  • d'Elia, G., and Perris, C. (1973). Cerebral functional dominance and depression.Acta Psychiatrica Scandinavica 49:191–197.

    PubMed  Google Scholar 

  • d'Elia, G., and Perris, C. (1974). Cerebral functional dominance and memory functions.Acta Psychiatrica Scandinavica Suppl. 255:143–157.

    Google Scholar 

  • DeFilippis, N. A., and McCampbell, E. (1979).The Booklet Category Test Manual, Psychological Assessment Resources. Odessa, FL.

    Google Scholar 

  • Delis, D. C., Kramer, J. H., Kaplan, E., and Ober, B. A. (1987).California Verbal Learning Test Manual, The Psychological Corporation, San Antonio, TX.

    Google Scholar 

  • Delvenne, M., Delecluse, F., Hubain, P., Schouten, A., DeMaertelaer, V., and Mendlewicz, J. (1990). Regional cerebral blood flow in patients with affective disorders.British Journal of Psychiatry 157:359–365.

    PubMed  Google Scholar 

  • Denman, S. B. (1984).Denman Neuropsychology Memory Scale, Charleston, SC.

  • Deptula, D., and Yozawitz, A. (1984). Lateralized brain dysfunction in depression: Analysis of memory.International Journal of Neuroscience 23:319.

    Google Scholar 

  • Derry, P. A., and Kuiper, N. A. (1981). Schematic processing and self-reference in clinical depression.Journal of Abnormal Psychology 90:286–297.

    PubMed  Google Scholar 

  • DeRubeis, R. J., Evans, M. D., Hollon, S. D., Garvey, M. J., Grove, W. M., and Tuason, V. B. (1990). How does cognitive therapy work? Cognitive change and symptom change in cognitive therapy and pharmacotherapy for depression.Journal of Consulting and Clinical Psychology 58:862–829.

    PubMed  Google Scholar 

  • Dimond, S. J., and Beaumont, J. G. (1974). Experimental studies of hemisphere function in the human brain. In Dimond, S. J., and Beaumont, J. G. (Eds.),Hemisphere Function in the Human Brain, Wiley, New York.

    Google Scholar 

  • Dobson, K. S. (1989). A meta-analysis of the efficacy of cognitive therapy for depression.Journal of Consulting and Clinical Psychology 57:414–419.

    PubMed  Google Scholar 

  • Dobson, K. S., and Shaw, B. F. (1986). Cognitive assessment with major depressive disorders.Cognitive Therapy and Research 10:13–29.

    Google Scholar 

  • Dolan, R. J., Bench, C. J., Brown, R. G., Scott, L. C., Friston, K. J., and Frackowiak, R. S. J. (1992). Regional cerebral blood flow abnormalities in depressed patients with cognitive impairment.Journal of Neurology, Neurosurgery, and Psychiatry 55:768–773.

    Google Scholar 

  • Eccles, J. C. (1977). Evolution of the brain in relation to the development of the self-conscious mind. In Dimond, S. J., and Blizard, D. A. (Eds.),Evolution and lateralization of the brain. Annals of the New York Academy of Science 299:161–279.

  • Evans, I. M. (1986). Response structure and the triple response-mode concept. In Nelson, R. O., and Hayes, S. C. (Ed.),Conceptual Foundations of Behavioral Assessment, Guilford Press, New York, pp. 131–151.

    Google Scholar 

  • Fennell, M. J. V. (1983). Cognitive therapy of depression: The mechanisms of change.Behavioral Psychotherapy 11:97–108.

    Google Scholar 

  • Fisher, D. G., Sweet, J. J., and Pfaelzer-Smith, E. A. (1986). Influence of depression on repeated neuropsychological testing.The International Journal of Clinical Neuropsychology 8:14–18.

    Google Scholar 

  • Flor-Henry, P. (1978). Gender, hemispheric specialization and psychopathology.Social Science and Medicine 12B:155–162.

    Google Scholar 

  • Flor-Henry, P. (1979). On certain aspects of the localization of the cerebral systems regulating and determining emotion.Biological Psychiatry 14:677–698.

    PubMed  Google Scholar 

  • Folstein, M. F., Maiberger, R., and McHugh, P. R. (1977). Mood disorder as a specific complication of stroke.Journal of Neurology, Neurosurgery, and Psychiatry 40:1018–1020.

    Google Scholar 

  • Frith, C. D., Stevens, M., Johnstone, E. C., Deakin, J. F. W., Lawler, P., and Crow, T. J. (1983). Effects of ECT and depression on various aspects of memory.British Journal of Psychiatry 142:610–617.

    PubMed  Google Scholar 

  • Fromm, D., and Schopflocher, D. (1984). Neuropsychological test performance in depressed patients before and after drug therapy.Biological Psychiatry 19:55–71.

    PubMed  Google Scholar 

  • Gainotti, G. (1972). Emotional behavior and hemispheric side of lesion.Cortex, 8:41–55.

    PubMed  Google Scholar 

  • Gasparrini, W. G., Satz, P., Heilman, K. M., and Coolidge, F. L. (1978). Hemispheric asymmetries of affective processing as determined by the Minnesota Multiphasic Personality Inventory.Journal of Neurology, Neurosurgery, and Psychiatry 41:470–473.

    Google Scholar 

  • Gauthier, J., Pellerin, D., and Renaud, P. (1983). The enhancement of self-esteem: A comparison of two cognitive strategies.Cognitive Therapy and Research 7:389–398.

    Google Scholar 

  • Gilley, D. W. (1990). Depression in cortical and subcortical demential syndromes. Dissertation, Virginia Polytechnic Institute and State University, Blacksburg, VA.

    Google Scholar 

  • Golden, C. J. (1978).Stroop Color and Word Test Manual, Stoelting Company, Chicago:

    Google Scholar 

  • Goldstein, K. (1939).The organism, Academic Book Publishers, New York.

    Google Scholar 

  • Grafman, J., Vance, S. C., Weingartner, H., Salazar, A. M., and Amin, D. (1986). The effects of lateralized frontal lesions on mood regulation.Brain, 109:1127–1148.

    PubMed  Google Scholar 

  • Greenberg, M. S., and Beck, A. T. (1989). Depression versus anxiety: A test of the contentspecificity hypothesis.Journal of Abnormal Psychology 98:9–13.

    PubMed  Google Scholar 

  • Gur, R. C., and Reivich, M. (1980). Cognitive task effects on hemispheric blood flow in humans: Evidence for individual differences in hemispheric activation.Brain and Language 9:78–92.

    PubMed  Google Scholar 

  • Gur, R. C., Gur, R. E., Obrist, W. D., Hungerbuhler, J. P., Younkin, D., Rosen, A. D., Skolnick, B. E., and Reivich, M. (1982). Sex and handedness differences in cerebral blood flow during rest and cognitive activity.Science 217:659–660.

    PubMed  Google Scholar 

  • Heaton, R. K. (1981).Wisconsin Card Sorting Test Manual, Psychological Assessment Resources, Odessa, FL.

    Google Scholar 

  • Heilman, K. M., and Valenstein, E. (1985).Clinical Neuropsychology, Oxford University Press, New York.

    Google Scholar 

  • Henriques, J. B., and Davidson, R. J. (1991). Left frontal hypoactivation in depression.Journal of Abnormal Psychology 100:535–545.

    PubMed  Google Scholar 

  • Hollon, S. D., DeRubeis, R. J., and Evans, M. D. (1987). Causal mediation of change in treatment for depression: Discriminating between nonspecificity and noncausality.Psychological Bulletin 102:139–149.

    PubMed  Google Scholar 

  • Hollon, S. D., Kendall, P. C., and Lumry, A. (1986). Specificity of depressotypic cognitions in clinical depression.Journal of Abnormal Psychology 95:52–59.

    PubMed  Google Scholar 

  • Hurwitz, T. A., Clark, C., Murphy, E., Klonoff, H., Martin, W. R. W., and Pate, B. D (1990). Regional cerebral glucose metabolism in major depressive disorder.Canadian Journal of Psychiatry 35:684–688.

    Google Scholar 

  • Ingram, R. E., Kendall, P. C., Smith, T. W., Donnell, C., and Ronan, K. (1987). Cognitive specificity in emotional distress.Journal of Personality and Social Psychology 53:734–742.

    PubMed  Google Scholar 

  • Jarrett, R. B., and Nelson, R. O. (1987). Mechanisms of change in cognitive therapy of depression.Behavior Therapy 18:227–241.

    Google Scholar 

  • Jarrett, R. B., Eaves, G. G., Grannemann, B. D., and Rush, A. J. (1991). Clinical, cognitive, and demographic predictors of response to cognitive therapy for depression: A preliminary report.Psychiatry Research 37:245–260.

    PubMed  Google Scholar 

  • Johnson, O., and Crockett, D. (1982). Changes in perceptual asymmetries with clinical improvement of depression and schizophrenia.Journal of Abnormal Psychology 91:45–54.

    PubMed  Google Scholar 

  • Jorge, R. E., Robinson, R. G., Starkstein, S. E. and Arndt, S. V. (1993). Depression and anxiety following traumatic brain injury.Journal of Neuropsychiatry and Clinical Neurosciences 5:369–374.

    PubMed  Google Scholar 

  • Kano, K., Nakamura, M., Matsuoka, T., Iida, H., and Nakajima, T. (1992). The topographical features of EEGs in patients with affective disorders.Electroencephalography and Clinical Neuropsychology 83:124–129.

    Google Scholar 

  • Keller, K. E. (1983). Dysfunctional attitudes and the cognitive therapy for depression.Cognitive Therapy and Research 7:437–444.

    Google Scholar 

  • Knott, V. J., and Lapierre, Y. D. (1987). Computerized EEG correlates of depression and antidepressant treatment.Progress in Neuro-Psychopharmacology Biological Psychiatry 11:213–221.

    PubMed  Google Scholar 

  • Kolb, B., and Whishaw, I. Q. (1990).Fundamentals of Human Neuropsychology (3rd ed.), W. H. Freeman, New York.

    Google Scholar 

  • Kovacs, M., and Beck, A. T. (1978). Maladaptive cognitive structures in depression.The American Journal of Psychiatry 135:525–533.

    PubMed  Google Scholar 

  • Kronfol, Z., Hamsher, K. deS., Digre, K., and Waziri, R. (1978). Depression and hemispheric functions: Changes associated with unilateral ECT.British Journal of Psychiatry 132:560–567.

    PubMed  Google Scholar 

  • Kulper, N. A., and MacDonald, M. R. (1983). Reason, emotion, and cognitive therapy.Clinical Psychology Review 3:297–316.

    Google Scholar 

  • Kwon, S. M., and Oei, T. P. S. (1992). Differential causal roles of dysfunctional attitudes and automatic thoughts in depression.Cognitive Therapy and Research 16:309–328.

    Google Scholar 

  • Lenhart, R. E., and Katkin, E. S. (1986). Psychophysiological evidence for cerebral laterality effects in a high-risk sample of students with subsyndromal bipolar depressive disorder.American Journal of Psychiatry 143:602–607.

    PubMed  Google Scholar 

  • Lezak, M. O. (1976).Neuropsychological Assessment, Oxford University Press, New York.

    Google Scholar 

  • Luria, A. R. (1973).The Working Brain: An Introduction to Neuropsychology, Penguin Books, New York.

    Google Scholar 

  • Martin, D. J., Oren, Z., and Boone, K. (1991). Major depressives' and dysthymics' performance on the Wisconsin Card Sorting Test.Journal of Clinical Psychology 47:684–690.

    PubMed  Google Scholar 

  • Mathew, R. J., Meyer, J. S., Francis, D. J., Semchuk, K. M., Mortel, K., and Claghorn, J. L. (1980). Cerebral blood flow in depression.American Journal of Psychiatry 137:1449–1450.

    PubMed  Google Scholar 

  • McAllister, T. W. (1981). Cognitive functioning in the affective disorders.Comprehensive Psychiatry 22:572–586.

    PubMed  Google Scholar 

  • McNamara, K., and Horan, J. J. (1986). Experimental construct validity in the evaluation of cognitive and behavioral treatments for depression.Journal of Counseling Psychology 33:23–30.

    Google Scholar 

  • Miller, I. W., III, and Norman, W. H. (1986). Persistence of depressive cognitions within a subgroup of depressed inpatients.Cognitive Therapy and Research 10:211–224.

    Google Scholar 

  • Miller, I. W., Norman, W. H., and Keitner, G. I. (1990). Treatment response of high cognitive dysfunction depressed inpatients.Comprehensive Psychiatry 30:62–71.

    Google Scholar 

  • Miller, W. R. (1975). Psychological deficit in depression.Psychological Bulletin 82:238–260.

    PubMed  Google Scholar 

  • Moreno, C. R., Borod, J. C., Welkowitz, J., and Alpert, M. (1990). Lateralization for the expression and perception of facial emotion as a function of age.Neuropsychologia 28:199–209.

    PubMed  Google Scholar 

  • Moscovitch, M., Strauss, E., and Olds, J. (1981). Handedness and dichotic listening performance in patients with unipolar endogenous depression who received ECT.American Journal of Psychiatry 138:988–990.

    PubMed  Google Scholar 

  • Myslobodsky, M. S., and Horesh, N. (1978). Bilateral electrodermal activity in depressive patients.Biological Psychology 6:111–120.

    PubMed  Google Scholar 

  • National Institute of Mental Health. (1989).Approaching the 21st century: Opportunities for NIMH neuroscience research (DHHS Publication No. ADM 89-1580) U. S. Government Printing Office, Washington, DC.

    Google Scholar 

  • Newman, P. J., and Silverstein, M. L. (1987). Neuropsychological test performance among major clinical subtypes of depression.Archives of Clinical Neuropsychology 2:115–125.

    PubMed  Google Scholar 

  • Newman, P. J., and Sweet, J. J. (1986). The effects of clinical depression on the Luria-Nebraska Neuropsychological Battery.International Journal of Clinical Neuropsychology 8:109–114.

    Google Scholar 

  • Otto, M. W., Yeo, R. A., and Dougher, M. J. (1987). Right hemisphere involvement in depression: Toward a neuropsychological theory of negative affective experiences.Biological Psychiatry 22:1201–1215.

    PubMed  Google Scholar 

  • Parikh, R. M., Lipsey, J. R., Robinson, R. G., and Price, T. R. (1988). A two-year longitudinal study of poststroke mood disorders: Prognostic factors related to one and two-year out-come.International Journal of Psychiatry in Medicine 18:45–56.

    PubMed  Google Scholar 

  • Persons, J. B., and Burns, D. B. (1985). Mechanisms of action of cognitive therapy: The relative contributions of technical and interpersonal interventions.Cognitive Therapy and Research 9:539–551.

    Google Scholar 

  • Phelps, M. E., Mazziotta, J. C., Baxter, L., and Gerner, R. (1984). Positron emission tomographic study of affective disorders: Problems and strategies.Annals of Neurology 15:S149-S156.

    PubMed  Google Scholar 

  • Reitan, R. M. (1979).Manual for Administration of Neuropsychological Test Batteries for Adults and Children, Reitan Neuropsychological Press, Tucson, AZ.

    Google Scholar 

  • Reitan, R. M., and Wolfson, D. (1993).Halstead-Reitan Neuropsychological Test Battery: Theory and Clinical Interpretation (2nd ed.), Neuropsychology Press, Tucson, AZ.

    Google Scholar 

  • Robinson, R. G., and Lipsey, J. R. (1985). Cerebral localization of emotion based on clinical-neuropathological correlations: Methodological issues.Psychiatric Developments 3:335–347.

    PubMed  Google Scholar 

  • Robinson, R. G., and Starkstein, S. E. (1989). Mood disorders following stroke: New findings and future directions.Journal of Geriatric Psychiatry 22:1–15.

    Google Scholar 

  • Robinson, R. G., and Szetela, B. (1981). Mood change following left hemispheric brain injury.Annals of Neurology 9:447–453.

    PubMed  Google Scholar 

  • Robinson, R. G., Kubos, K. L., Starr, L. B., Rao, K., and Price, T. R. (1983). Mood changes in stroke patients: Relationship to lesion location.Comprehensive Psychiatry 24:555–566.

    PubMed  Google Scholar 

  • Robinson, R. G., Kubos, K. L., Starr, L. B., Rao, K., and Price, T. R. (1984). Mood disorders in stroke patients: Importance of location of lesion.Brain 107:81–93.

    PubMed  Google Scholar 

  • Robinson, R. G., Lipsey, J. R., Bolla-Wilson, K., Bolduc, P. L., Pearlson, G. D., Rao, K., and Price, T. R. (1985a). Mood disorders in left-handed stroke patients.American Journal of Psychiatry 142:1424–1429.

    PubMed  Google Scholar 

  • Robinson, R. G., Starr, L. B., Lipsey, J. R., Rao, K., and Price, T. R. (1985). A two-year longitudinal study of poststroke mood disorders. In-hospital prognostic factors associated with six-month outcome.Journal of Nervous and Mental Disease 173:221–226.

    PubMed  Google Scholar 

  • Robinson, R. G., Lipsey, J.R., Rao, K., and Price, T. R. (1986). Two-year longitudinal study of poststroke mood disorders: Comparison of acute-onset with delayed-onset depression.American Journal of Psychiatry 143:1238–1244.

    PubMed  Google Scholar 

  • Rosenthal, M. (1984). Strategies for intervention with families of brain-injured patients. In Edelstein, B. A., and Couture, E. T. (Ed.),Behavioral Assessment and Rehabilitation of the Traumatic Brain-Damaged, Plenum Press, New York, pp. 227–246.

    Google Scholar 

  • Ross, E. D. (1981). The aprosodias: Functional-anatomic organization of the affective components of language in the right hemisphere.Archives of Neurology 38:561–569.

    PubMed  Google Scholar 

  • Ross, E. D. (1993). Nonverbal aspects of language.Behavioral Neurology 11:9–23.

    Google Scholar 

  • Ross, E. D., and Rush, A. J. (1981). Diagnosis and neuroanatomical correlates of depression in brain-damaged patients.Archives of General Psychiatry 38:1344–1354.

    PubMed  Google Scholar 

  • Ross, E. D., and Stewart, R. S. (1987). Pathological display of affect in patients with depression and right frontal brain damage.The Journal of Nervous and Mental Disease 175:165–172.

    PubMed  Google Scholar 

  • Ruckdeschel-Hibbard, M., Gordon, W. A., and Diller, L. (1986). Affective disturbances associated with brain damage. In Filskov, S. B., and Boll, T. J. (Eds.),Handbook of Clinical Neuropsychology. John Wiley and Sons. New York, pp. 305–337.

    Google Scholar 

  • Rush, A. J., Kovacs, M., Beck, A. T., Weissenburger, J., and Hollon, S. D. (1981). Differential effects of cognitive therapy and pharmacotherapy on depressive symptoms.Journal of Affective Disorders 3:221–229.

    PubMed  Google Scholar 

  • Sackeim, H. A., Greenberg, M. S., Weiman, A. L., Gur, R. C., Hungerbuhler, J. P., and Geschwind, N. (1982). Hemispheric asymmetry in the expression of positive and negative emotions.Archives of Neurology 39:210–218.

    PubMed  Google Scholar 

  • Savard, R. J., Rey, A. C., and Post, R. M. (1980). Halstead-Reitan category test in bipolar and unipolar affective disorders.The Journal of Nervous and Mental Disease 168:297–304.

    PubMed  Google Scholar 

  • Schaffer, C. E., Davidson, R. J., and Saron, C. (1983). Frontal and parietal electroencephalogram asymmetry in depressed and nondepressed subjects.Biological Psychiatry 18:753–761.

    PubMed  Google Scholar 

  • Schwartz, J. M., Baxter, L. R., Jr., Mazziotta, J. C., Gerner, R. H., and Phelps, M. E. (1987). The differential diagnosis of depression: Relevance of positron emission tomography studies of cerebral glucose metabolism to the bipolar-unipolar dichotomy.Journal of the American Medical Association 258:1368–1374.

    PubMed  Google Scholar 

  • Shipley, J. E., Kupfer, D. J., Spiker, D. G., Shaw, D. H., Coble, P. A., Neil, J. F., and Cofsky, J. (1981). Neuropsychological assessment and EEG sleep in affective disorders.Biological Psychiatry 16:907–918.

    PubMed  Google Scholar 

  • Silberman, E. K., Weingartner, H., Stillman, R., Chen, H. J., and Post, R. M. (1983). Altered lateralization of cognitive processes in depressed women.American Journal of Psychiatry 140:1340–1343.

    PubMed  Google Scholar 

  • Simons, A. D., Garfield, S. L., and Murphy, G. E. (1984). The process of change in cognitive therapy and pharmacotherapy for depression: Changes in mood and cognition.Archives of General Psychiatry 41:45–51.

    PubMed  Google Scholar 

  • Simons, A. D., Lustman, P. J., Wetzel, R. D., and Murphy, G. E. (1985). Predicting response to cognitive therapy of depression. The role of learned resourcefulness.Cognitive Therapy and Research 9:79–89.

    Google Scholar 

  • Sobotka, S. S., Davidson, R. J., and Senulis, J. A. (1992). Anterior brain electrical asymmetries in response to reward and punishment.Electroencephalography and Clinical Neurophysiology 83:236–247.

    PubMed  Google Scholar 

  • Sotsk, S. M., Elkin, I., Watkins, J. T., Collins, J. F., Shea, M. T., Leber, W. R., and Glass, D. R. (1990). Mode-specific effects among three treatments for depression.Journal of Consulting and Clinical Psychology 58:352–359.

    PubMed  Google Scholar 

  • Starkstein, S. E., Robinson, R. G., and Price, T. R. (1987). Comparison of cortical and subcortical lesions in the production of poststroke mood disorders.Brain, 110:1045–1059.

    PubMed  Google Scholar 

  • Starkstein, S. E., Bryet, J. B., Berthier, M. L., Cohen, B., Price, T. R., and Robinson, R. G. (1991). Depression after stroke: The importance of cerebral hemisphere asymmetries.Journal of Neuropsychiatry and Clinical Neurosciences 3:276–285.

    PubMed  Google Scholar 

  • Starkstein, S. E., Robinson, R. G., Honig, M. A., Parikh, R. M., Joselyn, J., and Price, T. R. (1989). Mood changes after right-hemisphere lesions.British Journal of Psychiatry 155:79–85.

    PubMed  Google Scholar 

  • Sternberg, D. E., and Jarvik, M. E. (1976). Memory functions in depression: Improvement with antidepressant medication.Archives of General Psychiatry 33:219–224.

    PubMed  Google Scholar 

  • Stromgren, L. S. (1977). The influence of depression on memory.Acta Psychiatrica Scandinavica 56:109–128.

    PubMed  Google Scholar 

  • Stuss, D. T., and Benson, D. F. (1984). Neuropsychological studies of the frontal lobes.Psychological Bulletin 95:3–28.

    PubMed  Google Scholar 

  • Swartzburg, M. (1983). Hemispheric laterality and EEG correlates of depression. Research Communications in Psychology.Psychiatry and Behavior 8:187–205.

    Google Scholar 

  • Teasdale, J. D., and Fennell, M. J. V. (1982). Immediate effects on depression of cognitive therapy interventions.Cognitive Therapy and Research 6:343–352.

    Google Scholar 

  • Thase, M. E., Simons, A. D., Cahalane, J. F., and McGeary, J. (1991). Cognitive behavior therapy of endogenous depression: Part 1: An outpatient clinical replication series.Behavior Therapy 22:457–467.

    Google Scholar 

  • Thase, M. E., Simons, A. D., Cahalane, J., McGeary, J., and Harden, T. (1991). Severity of depression and response to cognitive behavior therapy.American Journal of Psychiatry 148:784–789.

    PubMed  Google Scholar 

  • Tucker, D. M. (1981). Lateral brain function, emotion, and conceptualization.Psychological Bulletin 89:19–46.

    PubMed  Google Scholar 

  • Watson, C. G., Davis, W. E., and Gasser, B. (1978). The separation of organics from depressives with ability- and personality-based tests.Journal of Clinical Psychology 34:393–397.

    PubMed  Google Scholar 

  • Wechsler, D. (1981).WAIS-R Manual. Wechsler Adult Intelligence Scale—Revised, The Psychological Corporation, Cleveland, OH.

    Google Scholar 

  • Wechsler, D. (1987).WMS-R Manual: Wechsler Memory Scale Revised. The Psychological Corporation, New York.

    Google Scholar 

  • Weckowicz, T. E., Nutter, R. W., Cruise, D. G., Yonge, K. A., and Cairns, M. (1978). Speed in test performance in relation to depressive illness and age.Canadian Psychiatric Association Journal 23:107–109.

    PubMed  Google Scholar 

  • Wexler, B. E. (1980). Cerebral laterality and psychiatry: A review of the literature.The American Journal of Psychiatry 37:279–291.

    Google Scholar 

  • Wheeler, R. E., Davidson, R. J., and Tomarken, A. J. (1993). Frontal brain asymmetry and emotional reactivity: A biological substrate of affective style.Psychophysiology 30:82–89.

    PubMed  Google Scholar 

  • Whisman, M. A., Miller, I. W., Norman, W. H., and Keitner, G. I. (1991). Cognitive therapy with depressed inpatients: Specific effects on dysfunctional cognitions.Journal of Consulting and Clinical Psychology 59:282–288.

    PubMed  Google Scholar 

  • Wright, J. H., and Beck, A. T. (1983). Cognitive therapy of depression: Theory and practice.Hospital and Community Psychiatry 34:1119–1127.

    PubMed  Google Scholar 

  • Yozawitz, A., Bruder, G., Sutton, S., Sharpe, L., Gurland, B., Fleiss, J., and Costa, L. (1979). Dichotic perception: Evidence for right hemisphere dysfunction in affective psychosis.British Journal of Psychiatry 135:224–237.

    PubMed  Google Scholar 

  • Zeiss, A. M., Lewinsohn, P. M., and Munoz, R. F. (1979). Nonspecific improvement effects in depression using interpersonal skills training, pleasant activity schedules, or cognitive training.Journal of Consulting and Clinical Psychology 47:427–439.

    PubMed  Google Scholar 

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Crews, W.D., Harrison, D.W. The neuropsychology of depression and its implications for cognitive therapy. Neuropsychol Rev 5, 81–123 (1995). https://doi.org/10.1007/BF02208437

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