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Brief report: Neuroanatomic observations of the brain in pervasive developmental disorders

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Abstract

TheDiagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV; American Psychiatric Association, 1994) defines Pervasive Developmental Disorders (PDD) as those syndromes which are characterized by severe and pervasive impairment of reciprocal social skills, communication, or the presence of stereotyped interests and activities. Included under PDD are Autism, Rett's disorder, childhood disintegrative disorder, Asperger's Disorder, and Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS). To date, detailed neuroanatomic studies have been initiated in only two of these disorders, Autism and Rett syndrome (RS) and some very preliminary data are available for Asperger syndrome (AS).

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References

  • American Psychiatric Association. (1994).The diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.

    Google Scholar 

  • Armstrong, D. D. (1992). The neuropathology of Rett syndrome.Brain Development, 14(Suppl.), S89-S98.

    Google Scholar 

  • Bachevalier, J. (1991). An animal model for childhood autism. In C. A. Tamminga & S. C. Schultz (Eds.),Advances in neuropsychiatry and psychopharmacology (pp. 129–140). New York: Raven.

    Google Scholar 

  • Bachevalier, J., & Merjanian, P. (1994). The contribution of medial temporal lobe structures in autism: Neurobehavioral study in primates. In M. L. Bauman & T. L. Kemper (Eds.),The neurobiology of autism (pp. 146–169). Baltimore: Johns Hopkins University Press.

    Google Scholar 

  • Bauman, M. L., & Kemper, T. L. (1994). Neuroanatomic observations of the brain in autism. In M. L. Bauman & T. L. Kemper (Eds.),The neurobiology of autism (pp. 119–145). Baltimore: Johns Hopkins University Press.

    Google Scholar 

  • Bauman, M. L., & Kemper, T. L. (1995a). Brain weight in autism: Unexpected change with age. Unpublished data.

  • Bauman, M. L., & Kemper, T. L. (1995b). Quantitative analysis of Purkinje cell numbers in the vermis in autism as compared with controls. Unpublished data.

  • Bauman, M. L., Kemper, T. L., & Arin, D. M. (1995). Pervasive neuroanatomic abnormalities of the brain in Rett's syndrome.Neurology, 45, 1581–1586.

    Google Scholar 

  • Courchesne, E., Akshoomoff, N. A., & Townsend, J. (1992). Recent advances in autism. In H. Naruse & E. M. Ornitz (Eds.),Neurobiology of infantile autism (pp. 111–128). Amsterdam, The Netherlands: Elsevier.

    Google Scholar 

  • Fitzgerald, P. M., Jankovic, J., Glaze, D. G., Schultz, R., & Percy, A. K. (1990). Extrapyramidal involvement in Rett's syndrome.Neurology, 40, 293–295.

    Google Scholar 

  • Heath, R. G., & Harper, J. W. (1974). Ascending projections of the cerebellar nucleus to the hippocampus, amygdala and other temporal lobe sites: Evoked potential and histological studies in monkeys and cats.Experimental Neurology, 45, 268–287.

    Google Scholar 

  • Heath, R. G., Dempsey, C. W., Fontana, C. J., & Myers, W. A. (1978). Cerebellar stimulation: Effects on septal region, hippocampus and amygdala of cats and rats.Biological Psychiatry, 13, 501–529.

    Google Scholar 

  • Holmes, G., & Stewart, T. G. (1908). On the connection of the inferior olives with the cerebellum in man.Brain, 31, 125–137.

    Google Scholar 

  • Jellinger, K., & Seitelberger, F. (1986). Neuropathology of Rett syndrome.American Journal of Medical Genetics, 24(Suppl.), 259–288.

    Google Scholar 

  • Leiner, H. C., Leiner, A. L., & Dow, R. S. (1987). Cerebrocerebellar learning loops in apes and humans.Italian Journal of Neurological Science, 8, 425–436.

    Google Scholar 

  • McCormick, D. A., & Thompson, R. F. (1984). Cerebellum: Essential involvement in the classically conditioned eyelid response.Science, 223, 296–299.

    Google Scholar 

  • Naidu, S. (1994).Rett syndrome—new concepts and hypothesis. Satellite Symposium, conjoint meeting of the International Child Neurology, Association and Child Neurology Society. Portland, Oregon. October 1, 1994.

    Google Scholar 

  • Petersen, S. E., Fox, P. T., Posner, M. I., Mintum, M. A., & Raichle, M. E. (1989). Positron emission tomographic studies of the processing of single words.Journal of Cognitive Neuroscience, 1, 153–170.

    Google Scholar 

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Authors and Affiliations

  1. Department of Neurology, Massachusetts General Hospital, 32 Fruit Street, Burnham 731, 02115, Boston, Massachusetts

    Margaret L. Bauman

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  1. Margaret L. Bauman
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Bauman, M.L. Brief report: Neuroanatomic observations of the brain in pervasive developmental disorders. J Autism Dev Disord 26, 199–203 (1996). https://doi.org/10.1007/BF02172012

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