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Neonatal polycythaemia: Effect of partial dilutional exchange transfusion with human albumin on whole blood viscosity

  • Neonatology
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Abstract

Haematocrit (HCT) and viscosity of whole blood were measured in ten polycythaemic hyperviscous newborn infants both before and after dilutional partial exchange transfusion with 5% albumin. This was performed in order to evaluate the effect on the lowering of HCT and whole blood viscosity. Mean umbilical HCT values decreased from 68.7% before, to 54.4% post transfusion. This decrease in HCT and viscosity was highly significant (P<0.001). Safety and lack of complications make human albumin solution superior to human plasma for exchange transfusion in neonatal polycythaemia.

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Abbreviations

HCT:

haematocrit

References

  1. Black VD, Rumack CM, Lubchenco LD, Koops BL (1985) Gastrointestinal injury in polycythemic term infants. Pediatrics 76:225–231

    Google Scholar 

  2. Cuthbertson B, Rennie JG, Aw D, Reid KG (1987) Safety of albumin preparations manufactured from plasma not tested for HIV antibody. Lancet II:41

    Google Scholar 

  3. Ghosh S, Paton L (1985) Complications of therapeutic plasma exchange. Clin Lab Haematol 7:219–224

    Google Scholar 

  4. Linderkamp O, Versmold HT, Riegel KP, Betke K (1984) Contributions of red cells and plasma to blood viscosity in preterm and full term infants and adults. Pediatrics 74:45–51

    Google Scholar 

  5. Ring J, Messmer K (1977) Incidence and severity of anaphylactoid reactions to colloid volume substitutes. Lancet I:466–469

    Google Scholar 

  6. Shohat M, Merlob P, Reisner SH (1984) Neonatal polycythemia: I. Early diagnosis and incidence relating to time of sampling. Pediatrics 73:7–10

    Google Scholar 

  7. Shohat M, Reisner SH, Mimouni F, Merlob P (1984) Neonatal polycythemia: II. Definition related to time of sampling. Pediatrics 73:11–13

    Google Scholar 

  8. Wells JV, King MA (1980) Adverse reactions to human plasma protein. Anaesth Intensive Care 8:139–143

    Google Scholar 

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Authors and Affiliations

  1. Department of Neonatology, Beilinson Medical Centre, 49 100, Petah Tiqva, Israel

    I. Levy, P. Merlob, S. Ashkenazi & S. H. Reisner

  2. Tel Aviv University Sackler School of Medicine, 49 100, Petah Tiqva, Israel

    I. Levy, P. Merlob, S. Ashkenazi & S. H. Reisner

Authors
  1. I. Levy
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  2. P. Merlob
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  3. S. Ashkenazi
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  4. S. H. Reisner
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Levy, I., Merlob, P., Ashkenazi, S. et al. Neonatal polycythaemia: Effect of partial dilutional exchange transfusion with human albumin on whole blood viscosity. Eur J Pediatr 149, 354–355 (1990). https://doi.org/10.1007/BF02171566

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  • DOI: https://doi.org/10.1007/BF02171566

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