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Spontaneously (genetic) hypertensive rats: Naloxone-reversible and propranolol-reversible decrease in pain sensitivity

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Summary

Adult spontaneously hypertensive rats (SHR) are less sensitive to painful stimuli than their normotensive controls, Wistar-Kyoto (WKY) rats. This difference can be eliminated by the specific opiate antagonist, naloxone, and by the β-adrenergic blocking agent, propranol.

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Authors and Affiliations

  1. Section on Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health, 9000 Rockville Pike, 20205, Bethesda, Maryland, USA

    J. M. Saavedra

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  1. J. M. Saavedra
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Acknowledgment. The author wishes to thank Miss R. L. Holcomb for her editorial assistance.

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Saavedra, J.M. Spontaneously (genetic) hypertensive rats: Naloxone-reversible and propranolol-reversible decrease in pain sensitivity. Experientia 37, 1002–1003 (1981). https://doi.org/10.1007/BF01971804

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