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Rectal absorption of metronidazol from polyethylene glycol suppositories

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Abstract

The rectal absorption of metronidazol from an aqueous suspension, a fatty suppository and three different polyethylene glycol suppositories was studied in healthy volunteers and compared with absorption from an oral solution. Rectal absorption was found to be rather slow for all suppositories. Of all rectal dosage forms, the polyethylene glycol suppositories gave the highest peak plasma levels and the highest relative bioavailability. Compared with oral administration, a relative bioavailability of 80% could be obtained.

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References

  • De Blaey, C.J., andJ. Polderman (1980) In:Drug Design, Vol. 9 (Ariens, E.J., Ed.). Academic Press, London.

    Google Scholar 

  • De Boer, A.G., F. Moolenaar, L.G.J. De Leede andD.D. Breimer (1982)Clin. Pharmacokin. 7, 285–311.

    Google Scholar 

  • Ioannides, L., A. Somogyi, J. Spicer, B. Heinzow, N. Tong, C. Franklin andA. Mclean (1981)N. Eng. J. Med. 305, 1569–1570.

    Google Scholar 

  • Kakemi, K., T. Arita andS. Muranishi (1965)Chem. Pharm. Bull. 13, 969–975.

    PubMed  Google Scholar 

  • Krishnaswamy, K., andP.C. Teoh. (1980) In:Drug Treatment, 2nd ed. (Avery, G.S., Ed.). Adis Press, Sydney-New York, 1174–1210.

    Google Scholar 

  • Marques, R.A., B. Stafford, N. Flynn andW. Sadée (1978)J. Chromatogr. 146, 163–166.

    PubMed  Google Scholar 

  • Mclean, A., L. Ioannides, A. Somogyi, N. Tong andJ. Spicer (1983)Lancet 1, 41–43.

    PubMed  Google Scholar 

  • Moolenaar, F., J. Pronk, J. Visser andD.K.F. Meijer (1984)Int. J. Pharm., in press.

  • Schoonen, A.J.M., F. Moolenaar andT. Huizinga (1976)Pharm. Weekbl. 111, 585–589.

    Google Scholar 

  • Vromans, H., andF. Moolenaar (1984)Int. J. Pharm., submitted for publication.

  • Willis, A.T., I.R. Ferguson andP.H. Jones (1975)J. Antimicrob. Chemother. 1, 393–401.

    PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Pharmacology and Pharmacotherapeutics, Subfaculty of Pharmacy, State University of Groningen, Ant. Deusinglaan 2, 9713, AW Groningen, The Netherlands

    H. Vromans, F. Moolenaar, J. Visser & D. K. F. Meijer

Authors
  1. H. Vromans
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  2. F. Moolenaar
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  3. J. Visser
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  4. D. K. F. Meijer
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Vromans, H., Moolenaar, F., Visser, J. et al. Rectal absorption of metronidazol from polyethylene glycol suppositories. Pharmaceutisch Weekblad Scientific Edition 6, 18–20 (1984). https://doi.org/10.1007/BF01960193

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  • DOI: https://doi.org/10.1007/BF01960193

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