Abstract
Sixteen girls with Turner syndrome (TS) were treated for 4 years with biosynthetic growth hormone (GH). The dosage was 4IU/m2 body surface s.c. per day over the first 3 years. In the 4th year the dosage was increased to 61 U/m2 per day in the 6 girls with a poor height increment and in 1 girl oxandrolone was added. Ethinyl oestradiol was added after the age of 13. Mean (SD) growth velocities were 3.4 (0.9), 7.2 (1.7), 5.3 (1.3), 4.3 (2.0) and 3.6 (1.5) cm/year before and in the 1st, 2nd, 3rd and 4th year of treatment. Skeletal maturation advanced faster than usual in Turner patients especially in the youger children. Although the mean height prediction increased by 5.6 cm and 11 of the 16 girls have now exceeded their predicted height, the height of the 4 girls who stopped GH treatment exceeded the predicted adult height by only 0 to 3.4 cm.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- GH:
-
growth hormone
- GP:
-
Greulich and Pyle
- TS:
-
Turner syndrome
- TW-RUS:
-
Bone age according to the method of Tanner and Whitehouse (Radius, ulna and short bones
References
Greulich WW, Pyle SI (1959) Radiographic atlas of skeletal development of the hand and wrist. Stanford University Press, California
Joss EE (1988) Anabolic steroids in girls with Turner's Syndrome. Acta Paediatr Scand [Suppl] 343: 38–42
Laczi F, Julesz J, Janaky T, Laszlo FA (1979) Growth hormone reserve capacity in Turner's syndrome. Horm Metab Res 11: 664–666
Lenko HL (1979) Prediction of adult height with various methods in Finnish children. Acta Paediatr Scand 68: 85–92
Lyon AJ, Preece MA, Grant MB (1985) Growth curve for girls with Turner syndrome. Arch Dis Child 60: 932–935
Meadow SR, Boucher BJ, Mashitter K, King MNR, Stimmler L (1968) Growth hormone secretion in subjects with ovarian dysgenesis and Turner's Syndrome. Arch Dis Child 43: 595–597
Ranke MB, Stubbe P, Majewski F, Bierich JR (1988) Spontaneous growth in Turner's syndrome. Acta Paediatr Scand [Suppl] 343: 22–30
Roede MJ, Van Wieringen JC (1985) Growth diagrams 1980. Netherlands third nationwide survey. Tijdsch Soc Gezondheidszorg 63 [Suppl]: 1–34
Rongen-Westerlaken C, Fokker MH, Wit JM, et al (1990) Two year results of treatment with methionyl human growth hormone in girls with Turner syndrome. Acta Paed Scand 79: 658–663
Rongen-Westerlaken C, Wit JM, Drop SLS, et al (1988) Methionyl human growth hormone in Turner's syndrome. Arch Dis Child 63: 1211–1217
Rosenfeld RG, Hintz RL, Johanson AJ, et al (1988) Three year results of a randomized prospective trial of methionyl human growth hormone and oxandrolone in Turner syndrome. J Pediatr 113: 393–400
Rosenfeld RG, Hintz RL, Johanson AJ, et al (1986) Prospective, randomized trial of methionyl human growth hormone and/or oxandrolone in Turner syndrome. J Pediatr 109: 936–943
Snider ME, Solomon IL (1974) Ultimate height in chromosomal gonadal dysgenesis without androgen therapy. Am J Dis Child 127: 4
Sybert VP (1984) Adult height in Turner syndrome with and without androgen therapy. J Pediatr 104: 365–369
Tanner JM, Whitehouse RH, Takaishi M (1966) Standards from birth to maturity for height, weight, height velocity and weight velocity. British children, 1965 part II. Arch Dis Child 41: 613–694
Tanner JM, Whitehouse RH, Cameron N, Marshall WA, Healy MJR, Goldstein H (1983) Assessment of skeletal maturity and prediction of adult height (TW2-method). Academic Press, London
Zachmann M, Sobradillo B, Frank M, Frisch H, Prader A (1978) Bayley-Pinneau, Roche-Wainer-Thissen and Tanner height predictions in normal children and in patients with various pathologic conditions. J Pediatr 93: 749–755
Author information
Authors and Affiliations
Consortia
Rights and permissions
About this article
Cite this article
Rongen-Westerlaken, C., Wit, J.M., De Muinck Keizer-Schrama, S.M.P.F. et al. Growth hormone treatment in Turner syndrome accelerates growth and skeletal maturation. Eur J Pediatr 151, 477–481 (1992). https://doi.org/10.1007/BF01957747
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01957747