Abstract
Four patients are described who have two coexistent syndromes: the behavioral syndrome of autism and the biochemical syndrome of lactic acidosis. One of the four patients also had hyperuricemia and hyperuricosuria. These patients raise the possibility that one subgroup of the autism syndrome may be associated with inborn errors of carbohydrate metabolism.
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References
Becker, M. A., Paivio, K. O., Bakay, B., Adams, W. B., & Nyhan, W. L. (1980). Variant human phosphoribosylpyrophosphate synthetase altered in regulatory and catalytic functions.Journal of Clinical Investigation, 65, 109–120.
Blass, J. P. (1979). Disorders of pyruvate metabolism.Neurology, 29, 280–286.
Boullin, D. J., Coleman, M., & O'Brien, R. A. (1970). Abnormalities in platelet 5-hydroxytryptamine efflux in patients with infantile autism.Nature, 226, 371–372.
Brown, W. T., Jenkins, E. C., Friedman, E., Brooks, J., Wisniewski, K., Raguthu, S., & French, J. (1982). Autism is associated with the fragile-X syndrome.Journal of Autism and Development Disorders, 12, 303–308.
Chess, S., Korn, S. J., & Fernandez, P. (1971).Psychiatric disorders of children with congenital rubella. New York: Brunner/Mazel.
Cohen, D. J., Caparulo, B. K., Shaywitz, B. A., & Bowers, M. B. (1977). Dopamine and serotonin metabolism in neuropsychiatrically disturbed children.Archives of General Psychiatry, 34, 545–550.
Coleman, M. (Ed.). (1976).The autistic syndromes. Amsterdam: North-Holland.
Coleman, M., Landgrebe, M. A., & Landgrebe, A. R. (1976a). Purine autism. Hyperuricosuria in autistic children; does this identify a subgroup of autism? In M. Coleman (Ed.),The autistic syndromes. Amsterdam: North-Holland.
Coleman, M., Landgrebe, M. A.,& Landgrebe, A. R. (1976b). Celiac autism. Calcium studies and their relationship to celiac disease in autistic patients. in M. Coleman (Ed.),The autistic syndromes. Amsterdam: North-Holland.
Coleman, M., & Rimland, B. (1976). Familial autism. In M. Coleman (Ed.),The autistic syndromes. Amsterdam: North-Holland.
DeMyer, M. K., Schwier, H., Bryson, C. Q., Solow, E. B., & Roeske, N. (1971). Free fatty acid response to insulin and glucose stimulation in schizophrenic, autistic and emotionally disturbed children.Journal of Autism and Childhood Schizophrenia, 1, 436–452.
Friedman, E. (1969). The “autistic syndrome” and phenylketonuria.Schizophrenia,249.
Goldstein, M., Mahanand, D., Lee, J., & Coleman, M. (1976). Dopamine-eta-hydroxylase and endogenous total 5-hydroxyindole leels in autistic patients and controls. In M. Coleman (Ed.),The autistic syndromes. Amsterdam: North-Holland.
Hartmann, A. F., Wohltmann, H. S., Purkerson, M. L., & Wesley, M. E. (1962). Lactate metabolism — studies of a child with serious congenital deviation.Journal of Pediatrics, 61, 165.
Haworth, J. C., Ford, J. D., & Younoszai, M. K. (1967). Familial chronic acidosis due to an error in lactate and pyruvate metabolism.
Himwich, H. E., Jenkins, R. L., Fujimori, M., Narasimhachari, N., & Ebersole, M. (1972). A biochemical study of early infantile autism.Journal of Autism and Childhood Schizophrenia, 2, 114–126.
Kanner, L. (1943). Autistic disturbances in affective contact.Nervous Child, 2, 217.
Knobloch, H., & Pasamanick, B. (1975). Some etiologic and prognostic factors in early infantile autism and psychosis.Journal of Pediatrics, 55, 182.
Kuroda, Y., et al. (1979). Abnormal pyruvate and alpha-ketoglutarate dehydrogenase complexes in a patient with lactic acidemia.Pediatric Research, 13, 928.
Lake, C. R., Ziegler, M. G., & Murphy, D. L. (1977). Increased norepinephrine levels and decreased dopamine-beta-hydroxylase activity in primary autism.Archives of General Psychiatry, 34, 553–556.
Landgrebe, A. R., & Landgrebe, M. A. (1976). urinary catecholamine studies in autistic children. In M. Coleman (Ed.),The autistic syndromes. Amsterdam: North-Holland.
Nyhan, W. L., James, J. A., Tebert, A. J., Sweetman, L., & Nelson, L. G. (1969). A new disorder of purine metabolism with behavioral manifestations.Journal of Pediatrics, 74, 20.
Schain, R. J., & Freedman, D. X. (1961). Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children.Journal of Pediatrics, 58, 315.
Schain, R. J., & Yannet, H. (1960). Infantile autism. An analysis of 50 cases and a consideration of certain relevant neurophysiologic concepts.Journal of Pediatrics, 57, 560.
Valente, M. (1971). Autism: Symptomatic and idiopathic — and mental retardation.Pediatrics, 48, 495–496.
Yuwiler, A., Plotkin, S., Geller, E., & Ritvo, E. R. (1970). A rapid accurate procedure for the determination of serotonin in whole human blood.Biochemical Medicine, 3, 426.
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Coleman, M., Blass, J.P. Autism and lactic acidosis. J Autism Dev Disord 15, 1–8 (1985). https://doi.org/10.1007/BF01837894
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DOI: https://doi.org/10.1007/BF01837894