Abstract
The response of plasma 11-hydroxycorticosteroids (11-OHCS) to intravenous pyrogen as well as the circadian rhythm of plasma 11-OHCS levels were investigated in seven autistic children and in two children with Heller's syndrome. In autistic children, the stress response, which is acquired in an earlier stage of development, was adequately sustained. However, the circadian rhythm, which seems to appear at a later stage with the maturity of the CNS, frequently revealed abnormal patterns. Similar findings were obtained in the Heller's syndrome cases, indicating organic changes in the brain. On the basis of these results, it is postulated that in early infantile autism there exist some functional changes in the CNS that show a close correlation to the regulatory mechanism of ACTH secretion.
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Aarskog, D., Blizzard, R. M., & Migeon, C. J. Response to methopyrapone (SU-4885) and pyrogen test in idiopathic hypopituitary dwarfism.Journal of Clinical Endocrinology, 1965,25, 439–444.
Allen, C., & Kendall, J. W. Maturation of the circadian rhythm of plasma corticosterone in the rat.Endocrinology, 1967,80, 926–930.
Aoyagi, Y. Studies on adreno-cortical function tests in children. Part I. On total urinary excretion of 17-OHCS in healthy children.Acta Paediatrica Japonica, 1960,64, 1842–1848.
Asperger, H. Behavior problems and mental retardation. In P. W. Bowman (Ed.),Mental retardation: Proceedings of the First International Medical Conference. New York: Grune and Stratton, 1950.
Franks, R. C. Diurnal variation of plasma 17-hydroxycorticosteroids in children.Journal of Clinical Endocrinology, 1967,27, 75–78.
Greenberg, R., Gardner, L. T., & Lipfert, A. A. Studies on glucuronide conjugation and diurnal variation of urinary 17-hydroxycorticoids in the neonatal period.Journal of Diseases of Children, 1958,96, 520–521.
Jailer, J. W. The maturation of the pituitary-adrenal axis in the newborn rat.Endocrinology, 1950,46, 420–425.
Kawahara, H. Plasma levels of 17-hydroxycorticosteroids in umbilical cord blood, with special reference to variations of the level between A. umbilicalis and V. umbilicalis.Journal of Clinical Endocrinology, 1958,18, 325–327.
Makita, K. Early infantile autism, autismus infantum and pseudo-autism.Folia Psychiatrica et Neurologica Japonica, 1964,18, 97–111.
Makita, K., Nakamura, T., & Takahashi, T. A case report of Heller's disease.Japanese Journal of Child Psychiatry, 1960,1, 377–386.
Mattingly, D. A simple fluometric method for the estimation of free 11-hydroxycorticoids in human plasma.Journal of Clinical Pathology, 1962,15, 374–379.
Moyano, B. A., Outes, D. L., & Carrillo, A. Comentario sobre las 100 primeras autopsias en la Colonia de Retardos de Torres. Un estudio sobre las anomalias y lesiones en el cerebro de los idiotas.Archivio di Neurocirurgia, 1952,9, 263–331.
Okada, F. The maturation of the circadian rhythm of brain serotonin in the rat.Life Science, 1971,10, 77–86.
Schapiro, S., Geller, E., & Eduson, S. Neonatal adrenal cortical response to stress and vasopressin.Proceedings of the Society for Experimental Biology and Medicine, 1962,109, 937–941.
Takeuchi, S. Studies on urinary excretion of total 17-OHCS in infants and children. ActaPaediatrica Japonica, 1963,67, 44–49.
Tsuchiya, Y. Studies on the adrenocortical function in infants and children. ActaPaediatrica Japonica, 1963,67, 831–840.
Vaclav, H. Dementia infantilis Heller-Weygaudt.Zeitschrift für Kinderpsychiatrie, 1950,17, 97–105.
Yamazaki, K. Neuroendocrinological investigation in mental disorders, particularly in terms of pyrogen test. Part I. Standardization of pyrogen test and a study of general paresis.Psychiatria et Neurologia Japonica, 1970,72, 453–466. (a)
Yamazaki, K. Neuroendocrinological investigations in mental disorders, particularly in terms of pyrogen test. Part II. A study in schizophrenia and manic psychosis.Psychiatria et Neurologia Japonica, 1970,72, 467–483. (b)
Yamazaki, K., Saito, Y., Endo, M., Kato, H., Onodera, I., & Sakashita, A. Changes in concentration of 17-OHCS in blood upon administration of psilocybin.Clinical Endocrinology, 1968,16, 225–231.
Yamazaki, K., Yamashita, I., Moroji, T., Ito, K., & Suwa, N. Plasma 17-hydroxycorticosteroids response to pyrogen; a contribution to the standardization of the pyrogen test.Endocrinologia Japonica, 1969,16, 391–397.
Zappert, J. Dementia infantilis (Heller).Zeitschrift für Kinderpsychiatrie, 1938,41, 161–169.
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The authors are greatly indebted to Professor N. Suwa and Professor K. Makita for their advice and encouragement.
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Yamazaki, K., Saito, Y., Okada, F. et al. An application of neuroendocrinological studies in autistic children and Heller's syndrome. J Autism Dev Disord 5, 323–332 (1975). https://doi.org/10.1007/BF01540679
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DOI: https://doi.org/10.1007/BF01540679