Abstract
A follow-up study involving 85 autistic boys and 35 girls, c. 5 1/2 years of age at initial evaluation and 12 years at follow-up, is presented and discussed in considerable detail. Measures, also applied to 26 non-psychotic subnormal controls, included speech, social, educational, and family adequacy ratings, IQ's, and neurological data. Most autistic children remained educationally retarded and 42% were institutionalized. Good agreement with 2 studies by other authors indicated the following prognosis in autism: 1–2% recovery to normal, 5–15% borderline, 16–25% fair, and 60–75% poor. The best predictor of functional capacity in a work/school setting was the child's rating at intake. Performance IQ and severity of illness were next to best predictors. Case histories of 20 children with the best outcome, including 2 functioning normally, are compared and analyzed. Also, etiological implications of results are outlined in support of theories linking the cause of autism to biological factors.
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Alpern, G. D. & Boll, T. J.Development profile manual. Indianapolis: Psychological Development Publications, 1972.
Alpern, G. D., & Kimberlin, C. C. Short intelligence test ranging from infancy levels through childhood levels for use with the retarded.American Journal of Mental Deficiency, 1970,75, 65–71.
Beery, K. E.Development test of visual-motor integration: Administration and scoring manual. Chicago: Follet Educational Corp., 1967.
Chess, S., Korn, S. J., & Fernandez, P. B.Psychiatric disorders of children with congenital rubella. New York: Brunner/Mazel, 1971.
Churchill, D. W. The relation of infantile autism and early childhood schizophrenia to developmental language disorders of childhood.Journal of Autism and Childhood Schizophrenia, 1972,2, 182–197.
Conel, J.The postnatal development of the human cerebral cortex, Vol. I–VIII. Cambridge, Mass.: Harvard Unversity Press, 1968.
DeMyer, M. K., Alpern, G. D., Barton, S., DeMyer, W. E., Churchill, D. W., Hingtgen, J. N., Bryson, C. Q., Pontius, W., & Kimberlin, C. Imitation in autistic, early schizophrenic, and non-psychotic subnormal children.Journal of Autism and Childhood Schizophrenia, 1972,2, 264–287. (a)
DeMyer, M. K., Barton, S., & Norton, J. A. A comparison of adaptive, verbal and motor profiles of psychotic and non-psychotic subnormal children.Journal of Autism and Childhood Schizophrenia, 1972,2, 359–377. (b)
DeMyer, M. K., Churchill, D. W., Pontius, W., & Gilkey, K. A comparison of five diagnostic systems for childhood schizophrenia and infantile autism.Journal of Autism and Childhood Schizophrenia, 1971,1, 175–189.
DeMyer, M. K., Norton, J. A., & Barton, S. Social and adaptive behaviors of autistic children as measured in a structured psychiatric interview. In D. W. Churchill, G. D. Alpern, & M. K. DeMyer (Eds.),Infantile Autism: Proceedings of the Indiana University Colloquium. Springfield: Charles C Thomas, 1971.
DeMyer, M. K., Norton, J., & Barton, S.A system for predicting outcome in autistic and other subnormal children. Research Report No. 11. Indianapolis: Clinical Research Center for Early Childhood Schizophrenia, 1973.
DeMyer, M. K., Pontius, W., Norton, J. A., Barton, S., Allen, J., & Steele, R. Parental practices and innate activity in normal, autistic, and brain-damaged infants.Journal of Autism and Childhood Schiophrenia, 1972,2, 49–66. (c)
Dixon, W. J. (Ed.)BMD-biomedical computer programs. Berkeley: University of California Press, 1967.
Doll, E. A.Vineland social maturity scale manual of directions. Minneapolis: Educational Test Bureau, 1947.
EEG-Olofsson, O. The development of the electroencephalogram in normal children and adolescents from the age of 1 through 21 years.Acta Paediatrica Scandinavica, Supplementum 208, 1971.
Eisenberg, L. The autistic child in adolescence.American Journal of Psychiatry, 1956,112, 607–613.
Gesell, A., & Amatruda, C.Developmental diagnosis. New York: Paul B. Hoeber, 1951.
Gittelman, M., & Birch, H. G. Childhood schizophrenia: Intellect, neurologic status, perinatal risk, prognosis, and family pathology.Archives of General Psychiatry, 1967,17, 16–25.
Goodenough, F. L.Measurement of intelligence by drawings. New York: Harcourt, Brace, & World, 1926.
Hingtgen, J. N., & Churchill, D. W. Identification of perceptual limitations in mute autistic children.Archives of General Psychiatry, 1969,21, 68–71.
Kanner, L. Follow-up study of eleven autistic children originally reported in 1943.Journal of Autism and Childhood Schizophrenia, 1971,1, 119–145.
Koppitz, E. M.The Bender-Gestalt test for young children. New York: Grune & Stratton, 1971.
Lobascher, M. D., Kingerlee, P. E., & Gubbay, S. S. Childhood autism: An investigation of aetiological factors in 25 cases.British Journal of Psychiatry, 1970,117, 525–540.
Mittler, P., Gillies, S., & Jukes, E. Prognosis in psychotic children: Report of follow-up study.Journal of Mental Deficiency Research, 1966,10, 73–83.
Rutter, M., & Lockyer, L. A five to fifteen year follow-up study of infantile psychosis. I. Description of the sample.British Journal of Psychiatry, 1967,113, 1169–1182. (a)
Rutter, M., & Lockyer, L. A five to fifteen year follow-up study of infantile psychosis. II. Social and behavioural outcome.British Journal of Psychiatry, 1967,113, 1183–1199. (b)
Sheridan, M. D.The developmental progress of infants and young children: Ministry of Health reports on public health and medical subjects. London: Her Majesty's Stationery Office, No. 102, 1960.
Small, J. G., DeMyer, M. K., & Milstein, V. CNV responses of autistic and normal children.Journal of Childhood Schizophrenia, 1971,1, 215–231.
Stutsman, R.Mental measurement of preschool children with a guide for administering the Merrill-Palmer scale of mental tests. New York: Harcourt, Brace, & World, 1948.
Terman, L. M., & Merrill, M. A.Stanford-Binet intelligence scale, manual for the third revision Form L-M. Boston: Houghton Mifflin, 1960.
Wechsler, D.Wechsler intelligence scale for children: Manual. New York: The Psychological Corp., 1949.
Yakovlev, P. K. Morphological criteria of growth and maturation in the nervous system in man.Research Publication of the Association for Nervous and Mental Diseases, 1962,39, 3–46.
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This study was supported in part by Public Health Service Grant No. MH05154, PHS Grant RR-00162, and also by LaRue D. Carter Memorial Hospital, Indianapolis, Indiana. The assistance of the Indiana University Medical Center's Research Computation Center, which is supported in part by PHS Grant RR-00162, is gratefully acknowledged.
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DeMyer, M.K., Barton, S., DeMyer, W.E. et al. Prognosis in autism: A follow-up study. J Autism Dev Disord 3, 199–246 (1973). https://doi.org/10.1007/BF01538281
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DOI: https://doi.org/10.1007/BF01538281