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A case of infantile autism associated with Down's syndrome

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Abstract

There is increasing recognition that autism is a syndrome, not a disease entity. But it is not yet clear why some children develop autistic behavior more easily than others. It has been noted that autistic symptoms occur more frequently in children with mental retardation, blindness, congenital rubella, phenylketonuria, etc., and that there are very few cases of classical infantile autism in the general population. Very rarely has autism been associated with Down's syndrome. This is a report of a case of Down's syndrome and infantile autism.

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References

  • Abrams, N., & Pergament, E. Childhood psychosis combined with XYY abnormalities.Journal of Genetic Psychology, 1971,118, 13–16.

    PubMed  Google Scholar 

  • Bender, L., & Sankar, D. V. S. Chromosome damage not found in leukocytes of children treated with LSD-25.Science, 1968,159, 749.

    Google Scholar 

  • Biesele, J. J., Schmid, W., & Laulis, M. G. Mentally retarded schizoid twin girls with 47 chromosomes.Lancet, 1962,1, 403–405.

    PubMed  Google Scholar 

  • Böök, J. A., Nichtern, S., & Grenberg, E. Cytogenetical investigations in childhood schizophrenia.Acta Psychiatrica Scandinavica, 1963,39, 309–323.

    PubMed  Google Scholar 

  • Chess, S. Autism in children with congenital rubella.Journal of Autism and Childhood Schizophrenia, 1971,1, 34–47.

    Google Scholar 

  • Chess, S. Follow-up report on autism in congenital rubella.Journal of Autism and Childhood Schizophrenia, 1977,7, 69–81.

    PubMed  Google Scholar 

  • Coleman, M. Introduction. In M. Coleman (Ed.),The autistic syndromes. Amsterdam: North-Holland, 1976.

    Google Scholar 

  • Domino, G., Goldshmid, M., & Kaplan, M. Personality traits of institutionalized mongoloid girls.American Journal of Mental Deficiency, 1963,68, 498–502.

    Google Scholar 

  • Friedman, E. The “autistic syndrome” and phenylketonuria.Schizophrenia, 1969,1, 249–261.

    Google Scholar 

  • Hackney, I. M. Autistic behavior patterns in phenylketonuric children.Canadian Psychiatric Association Journal, 1967,12, 333–334.

    PubMed  Google Scholar 

  • Judd, L. L., & Mandel, A. J. Chromosome studies in early infantile autism.Archives of General Psychiatry, 1968,18, 450–457.

    PubMed  Google Scholar 

  • Kanner, L. Autistic disturbances of affective contact.Nervous Child, 1943,2, 217–250.

    Google Scholar 

  • Kanner, L.Child psychiatry (4th ed.). Springfield, Illinois: Charles C Thomas, 1972.

    Google Scholar 

  • Knobloch, H., & Pasamanick, B. (Eds.).Gesell and Amaturda's developmental diagnosis (3rd ed.). New York: Harper & Row, 1974.

    Google Scholar 

  • Krug, O., Gardner, G. E., Hirscberg, J. C., Lourie, R. S., Rexford, E. N., & Robinson, J. F. (Eds.).Career training in child psychiatry. Report of the Conference on Training in Child Psychiatry, Washington, D.C., January, 1963. Washington, D.C.: American Psychiatric Association, 1964. Pp. 126–127.

    Google Scholar 

  • Langdon-Down, J. Observation on an ethnic classification of idiots.London Hospital Reports, 1866,3, 259–269.

    Google Scholar 

  • Makita, K. Diagnostic criteria and nosology of infantile autism.Japanese Journal of Child Psychiatry, 1966,7, 54–72. (in Japanese)

    Google Scholar 

  • Menolascino, F. J. Psychiatric aspects of mongolism.American Journal of Mental Deficiency, 1964,69, 653–660.

    Google Scholar 

  • Nielsen, J., Christensen, K. R., Friedrich, U., Zeuthen, E., & Ostergaard, O. Childhood of males with XYY syndrome.Journal of Autism and Childhood Schizophrenia, 1973,3, 5–26.

    PubMed  Google Scholar 

  • Rollin, H. R. Personality in mongolism with special reference to the incidence of catatonic psychosis.American Journal of Mental Deficiency, 1946,51, 219–237.

    Google Scholar 

  • Rutter, M. The influence of organic and emotional factors on the origins, nature and outcome of childhood psychosis.Developmental Medicine and Child Neurology, 1965,7, 518–528.

    PubMed  Google Scholar 

  • Turner, B., & Jennings, A. N. Trisomy for chromosome 22.Lancet, 1961,2, 49–50.

    Google Scholar 

  • Werkman, S. Childhood emotional disorders. In A. Deutsch & H. Fishman (Eds.),The encyclopedia of mental health (Vol. 1). New York: Franklin Watts, 1963. Pp. 303–312.

    Google Scholar 

  • Wing, L. The handicaps of autistic children—a comparative study.Journal of Child Psychology and Psychiatry, 1969,10, 1–40.

    PubMed  Google Scholar 

  • Wolraich, M., Bzostek, B., Neu, R. L., & Gardner, L. T. Lack of chromosome aberrations in autism.New England Journal of Medicine, 1910,283, 1231.

    Google Scholar 

  • Warkman, S. InEncyclopedia of mental health, I. New York: Franklin Watts, 1963. Pp. 311–313.

    Google Scholar 

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The author is greatly indebted to Prof. Y. Kasahara of Nagoya University for his revision of the manuscript and to Prof. K. Makita of Tokai University for his comments and help in preparing the manuscript.

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Wakabayashi, S. A case of infantile autism associated with Down's syndrome. J Autism Dev Disord 9, 31–36 (1979). https://doi.org/10.1007/BF01531289

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  • DOI: https://doi.org/10.1007/BF01531289

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