Skip to main content
Log in

Can standard measures identify subclinical markers of autism?

  • Published:
Journal of Autism and Developmental Disorders Aims and scope Submit manuscript

Abstract

This study compared the executive function and theory-of-mind abilities of siblings of autistic individuals to those of siblings of learning-disabled controls. Three different analyses of the dependent measures provided convergent support for a potential subclinical marker in the executive function domain. No group differences in theory-of-mind abilities were found. However, power analyses revealed that the measures employed in this study, which are typically used with autistic individuals, were not sufficiently sensitive to detect any group differences that might exist in “unaffected” family members. Suggestions for future research are provided, including the need to develop more sensitive tasks that produce larger effects and measure more elementary cognitive operations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • August, G. J., Stewart, M. A. & Tsai, L. (1981). The incidence of cognitive disabilities in the siblings of autistic children.British Journal of Psychiatry, 138, 416–422.

    Google Scholar 

  • Baird, T. D. & August, G. J. (1985). Familial heterogeneity in infantile autism.Journal of Autism and Developmental Disorders, 15, 315–321.

    Google Scholar 

  • Baron-Cohen, S. (1989). The autistic child's theory of mind: A case of specific developmental delay.Journal of Child Psychology and Psychiatry, 30, 285–297.

    Google Scholar 

  • Baron-Cohen, S., Leslie, A. M., & Frith, U. (1985). Does the autistic child have a “theory of mind?”Cognition, 21, 37–46.

    Google Scholar 

  • Baron-Cohen, S., Leslie, A. M., & Frith, U. (1986). Mechanical, behavioral and intentional understanding of picture stories in autistic children.British Journal of Developmental Psychology, 4, 113–125.

    Google Scholar 

  • Borys, S. V., Spitz, H. H., & Dorans, B. A. (1982). Tower of Hanoi performance of retarded young adults and nonretarded children as a function of solution length and goal state.Journal of Experimental Child Psychology, 33, 87–110.

    Google Scholar 

  • Courchesne, E., Townsend, J. P., Akshoomoff, N. A., Yeung-Courchesne, R., Press, G. A., Murakami, J. W., Lincoln, A. J., James, H. E., Saitoh, O., Haas, R. H., & Schreibman, L. (in press). A new finding in autism: Impairment in shifting attention. In S. H. Broman & J. Grafman (Eds.),Atypical cognitive deficits in developmental disorders: Implications for brain function. Hillsdale, NJ: Lawrence Erlbaum.

  • Flavell, J. H., Botkin, P. T., Fry, C. L., Wright, J. W., & Jarvis, P. E. (1968).The development of role-taking and communication skills in children. New York: Wiley.

    Google Scholar 

  • Folstein, S. E., & Rutter, M. (1977). Infantile autism: A genetic study of 21 twin pairs.Journal of Child Psychology and Psychiatry, 18, 297–321.

    Google Scholar 

  • Folstein, S. E., & Rutter, M. (1988). Autism: Familial aggregation and genetic implications.Journal of Autism and Developmental Disorders, 18, 3–30.

    Google Scholar 

  • Freeman, B. J., Ritvo, E. R., Mason-Brothers, A., Pingree, C., Hokota, A., Jenson, W. R., McMahon, W. M., Petersen, P. B., Mo, A., & Schroth, P. (1989). Psychometric assessment of first-degree relatives of 62 autistic probands in Utah.American Journal of Psychiatry, 146, 361–364.

    Google Scholar 

  • Garfin, D. G., McCallon, D., & Cox, R. (1988). Validity and reliability of the Childhood Autism Rating Scale with autistic adolescents.Journal of Autism and Developmental Disorders, 18, 367–378.

    Google Scholar 

  • Harris, P. L. (1993). Petending and planning. In S. baron-Cohen, H. Tager-Flusberg, & D. Cohen (Eds.),Understanding other minds: Perspectives from autism (pp. 228–246). New York: Oxford University Press.

    Google Scholar 

  • Heaton, R. K. (1981).Wisconsin card sorting test manual. Odessa, FL: Psychological Assessment Resources.

    Google Scholar 

  • Hughes, C., & Russell, J. (1993). Autistic children's difficulty with mental disengagement from an object: its implications for theories of autism.Developmental Psychology, 29, 498–510.

    Google Scholar 

  • Jensen, R. A. (1991). Family characteristics of autistic children: A further report [Letter to the Editor].Journal of Autism and Developmental Disorders, 21, 557–558.

    Google Scholar 

  • Kraemer, H. C., & Thiemann, S. (1987).How many subjects: Statistical power analysis in research. Beverly Hills: Sage.

    Google Scholar 

  • Landa, R., Folstein, S. E., & Isaacs, C. (1991). Spontaneous narrative discourse performance of parents of autistic individuals.Journal of Speech and Hearing Research, 34, 1339–1345.

    Google Scholar 

  • McEvoy, R. E., Rogers, S. J., & Pennington, B. F. (1993). Executive function and social communication deficits in young autistic children.Journal of Child Psychology and Psychiatry, 34, 563–578.

    Google Scholar 

  • Minton, J., Campbell, M., Green, W. H., Jennings, S., & Samit, C. (1982). Cognitive assessment of siblings of autistic children.Journal of the American Academy of Child Psychiatry, 21, 256–261.

    Google Scholar 

  • Ozonoff, S. (in press). Executive functions in autism. In E. Schopler & G. B. Mesibov (Eds.),Learning and cognition in autism. New York: Plenum Press.

  • Ozonoff, S., Pennington, B. F., & Rogers, S. J. (1991). Executive function deficits in high-functioning autistic individuals: Relationship to theory of mind.Journal of Child Psychology and Psychiatry, 32, 1081–1105.

    Google Scholar 

  • Pennington, B. F. (in press). The working memory function of the prefrontal cortices: Implications for developmental and individual differences in cognition. In M. Haith (Ed.),Future-oriented processes in development. Chicago: University of Chicago Press.

  • Perner, J., Frith, U., Leslie, A. M., & Leekam, S. R. (1989). Exploration of the autistic child's theory of mind: Knowledge, belief and communication.Child Development, 60, 689–700.

    Google Scholar 

  • Prior, M., & Hoffmann, W. (1990). Neuropsychological testing of autistic children through an exploration with frontal lobe tests.Journal of Autism and Developmental Disorders, 20, 581–590.

    Google Scholar 

  • Rumsey, J. M., & Hamburger, S. D. (1988). Neurosychological findings in high-functioning autistic men with infantile autism, residual state.Journal of Clinical and Experimental Neuropsychology, 10, 201–221.

    Google Scholar 

  • Rumsey, J. M., & Hamburger, S. D. (1990). Neuropsychological divergence of high-level autism and severe dyslexia.Journal of Autism and Developmental Disorders, 20, 155–168.

    Google Scholar 

  • Sattler, J. M. (1988).Assessment of children (3rd ed.). San Diego: J. M. Sattler.

    Google Scholar 

  • Schopler, E., Reichler, R. J., & Renner, B. R. (1988).The Childhood autism rating scale (CARS), Los Angeles: Western Psychological Services.

    Google Scholar 

  • Smalley, S. L., & Asarnow, R. F. (1990). Brief report: Cognitive subclinical markers in autism.Journal of Autism and Developmental Disorders, 20, 271–278.

    Google Scholar 

  • Smalley, S. L., Asarnow, R. F., & Spence, M. A. (1988). Autism and genetics: A decade of research.Archives of General Psychiatry, 45, 953–961.

    Google Scholar 

  • Welsh, M. C., Pennington, B. F., & Groisser, D. B. (1991). A normative-developmental study of executive function: A window on prefrontal function in children.Developmental Neuropsychology, 7, 131–149.

    Google Scholar 

  • Wolff, S., Narayan, S., & Moyes, B. (1988). Characteristics of parents of autistic children: A controlled study.Journal of Child Psychology and Psychiatry, 29, 143–153.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Preparation of this article was supported in part by a National Institute of Mental Health Grant MH46035-01 to Sally Rogers and Sally Ozonoff, and by an NIMH RSDA (MH00419) and MERIT award (MH38820) to Bruce Pennington. We gratefully acknowledge Joseph Piven for his suggestions for data analysis, John Flavell for sharing his measures with us, Larry Epstein and Chris Saiz for aid in data collection, and two anonymous reviewers for their helpful comments.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ozonoff, S., Rogers, S.J., Farnham, J.M. et al. Can standard measures identify subclinical markers of autism?. J Autism Dev Disord 23, 429–441 (1993). https://doi.org/10.1007/BF01046049

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01046049

Keywords

Navigation