Abstract
The aim of this study is to evaluate the frequency and relative importance of different aspects of health related quality of life (HRQOL) impairment in patients with hypothyroidism. A survey of 200 patients with treated hypothyroidism was undertaken. Patients were identified and questionnaires distributed through family physicians, endocrinologists, and regional branches of the Thyroid Foundation of Canada. Frequency of importance of patients' symptoms attributed to hypothyroidism and resolved or improved with treatment were measured. Establishing the wide variety of patient-specific complaints associated with hypothyroidism provides guidance for clinicians dealing with hypothyroid patients, and investigators interested in HRQOL impairment in these patients.
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References
Pacchiarotti A, Martino E, Bartalena L et al. Serum free thyroid hormones in subclinical hypothyroidism. J Endocrinol Invest 1986; 9: 315–9.
Bell GM, Todd WTA, Forfar JC et al. End-organ responses to thyroxine in subclinical hypothyroidism. Clin Endocrinol 1985; 22: 83–9.
Cooper DS, Halpern R, Wood LC, Levin AA, Ridgway EC. l-Thyroxine therapy in subclinical hypothyroidism. A double blind, placebo controlled trial. Ann Intern Med 1984; 101: 18–24.
Lim SV, Zavala DC, Flanigan MJ, Freeman RM. Basal oxygen uptake: a new technique for an old test. J Clin Endocrinol Metabol 1986; 62: 863–8.
Gupta SP, Kumar V, Ahuija MMS. Evaluation of Achilles reflex time as a test of thyroid function. South Med J 1973; 66: 764–8.
Billewicz WZ, Chapman RS, Crooks J et al. Statistical methods applied to the diagnosis of hypothyroidism. QJ Med 1969; 38: 255–66.
Barker DJP, Bishop JM. Computer-based screening system for patients at risk of hypothyroidism. Lancet 1969; 2: 835–838.
Harrison LC, Buckley JD, Martin FIR. Use of a computer-based postal questionnaire for the detection of hypothyroidism following radioiodine therapy for thyrotoxicosis. Austral NZ J Med 1977; 7: 27–32.
Jaeschke R, Guyatt GH. How to develop and validate a new quality of life instrument. In: Spilker B, ed. Quality of Life Assessment in Clinical Studies. Raven Press, New York, 1990: 47–60.
Guyatt GH, Berman LB, Townsend M, Pugsley SO, Chambers LW. A measure of quality of life for clinical trials in chronic lung disease. Thorax 1987; 42: 773–8.
Guyatt GH, Nogradi S, Halcrow S, Singer J, Sullivan MJ, Fallen EL. Development and testing of a new measure of health status for clinical trials in heart failure. J Gen Intern Med 1989; 4: 101–7.
Juniper EF, Guyatt GH, Epstein RS et al. Evaluation of quality of life in asthma: development of a questionnaire for use in clinical trials. Thorax 1992; 47: 76–83.
Guyatt GH, Eagle DJ, Sackett B et al. Development and testing of a questionnaire to measure quality of life in the frail elderly. J Clin Epidemiol 1993; 46: 1433–1444.
Jaeschke R, Guyatt GH, Cook D. Quality of life instrument in evaluation of new drugs. Pharmaco-Economics 1992; 2: 84–93.
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The study was funded by a grant from Boots Pharmaceuticals. Drs Cook and Guyatt are career scientists of the Ontario Ministry of Health.
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Jaeschke, R., Guyatt, G., Cook, D. et al. Spectrum of quality of life impairment in hypothyroidism. Qual Life Res 3, 323–327 (1994). https://doi.org/10.1007/BF00451724
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DOI: https://doi.org/10.1007/BF00451724