Abstract
Effects of cerebellar lesions on the production of isometric pinch force and the coordination of pinch and lift force were examined. Twenty-one patients, mostly with degenerative cerebellar disorders, and ten healthy controls lifted an instrumented test object using the precision grip of thumb and index finger. The load of the object could be varied to study the adaptation of pinch force generation. The results were: (1) Cerebellar patients were able to adapt their pinch force levels to the different object loads. (2) Patients showed a longer latency between the onset of pinch force and onset of lift force than controls. The level of pinch force at the start of lift force was elevated. (3) Patients were able to use sensori-motor memory about object load to adapt force output based on previous experience through repetitive testing, but they were significantly less efficient than healthy controls. (4) The temporal profile of pinch force rate of change featured an irregular pattern characteristic for a lack of sufficient anticipatory parameterization.
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References
Athènes S, Wing AM (1989) Knowledge-directed coordination in reaching for objects in the environment. In: Wallace SA (ed) Perspectives on the coordination of movement. North-Holland, Amsterdam, pp 285–301
Becker WJ, Kunesch E, Freund HJ (1990) Coordination of a multi-joint movement in normal humans and in patients with cerebellar dysfunction. Can J Neurol Sci 17:264–274
Cole KJ (1991) Grasp force control in older adults. J Mot Behav 23:251–258
Cooke JD (1980) The organization of simple, skilled movements. In: Stelmach GE, Requin J (ed) Tutorials in motor behavior. North-Holland, Amsterdam, pp 199–212
Diener HC, Dichgans J, Guschlbauer B, Bacher M, Rapp H, Klockgether T (1992) The coordination of posture and voluntary movement in patients with cerebellar dysfunction. Mov Disord 7:14–22
Espinoza E, Smith AM (1990) Purkinje cell simple spike activity during grasping and lifting objects of different textures and weights. J Neurophysiol 64:698–714
Favilla M, Gordon J, Hening W, Ghez C (1990) Trajectory control in targeted force impulses. VII. Independent setting of amplitude and direction in response preparation. Exp Brain Res 79:530–538
Goodkin HP, Keating JG, Martin TA, Thach WT (1993) Preserved simple and impaired compound movement after infarction in the territory of the superior cerebellar artery. Can J Neurol Sci [Suppl 3] 20:S93-S104
Gordon AM, Forssberg H, Johansson RS, Westling G (1991) Visual size cues in the programming of manipulative forces during precision grip. Exp Brain Res 83:477–482
Gordon J, Ghez C (1987) Trajectory control in targeted force impulses. II. Pulse height control. Exp Brain Res 76:241–252
Harding AE (1983) Classification of the hereditary ataxias and paraplegias. Lancet 1:1151–1154
Holmes G (1917) The symptoms of acute cerebellar injuries due to gunshot injuries. Brain 40:461–535
Holmes G (1939) The cerebellum of man. Brain 62:1–30
Hore J, Wild B, Diener HC (1991) Cerebellar dysmetria at the elbow, wrist and fingers. J Neurophysiol 65:563–571
Johansson RS, Cole KJ (1992) Sensory-motor coordination during grasping and manipulative actions. Curr Opin Neurobiol 2:815–23
Johansson RS, Westling G (1984) Roles of glabrous skin receptors and sensorimotor memory in automatic control of precision grip when lifting rougher or more slippery objects. Exp Brain Res 56:550–564
Johansson RS, Westling G (1988) Coordinated isometric muscle commands adequately and erroneously programmed for the weight during lifting task with precision grip. Exp Brain Res 71:59–71
Klockgether T, Wüllner U, Dichgans J, Grodd W, Nägele T, Petersen D, Schroth G, Schmidt O, Voigt K (1993) Clinical and imaging correlations in inherited ataxias. Adv Neurol 61:77–96
Mai N, Bolsinger P, Avarello M, Diener HC, Dichgans J (1988) Control of isometric finger force in patients with cerebellar disease. Brain 111:973–998
Müller F, Dichgans J (1994) Impairments of precision grip in two patients with acute unilateral cerebellar lesions: a simple parametric test for clinical use. Neuropsychologia 32:265–269
Thach WT, Goodkin HP, Keating JG (1992) The cerebellum and the adaptive coordination of movement. Annu Rev Neurosci 15:403–442
Thompson PD, Day BL (1993) The anatomy and physiology of cerebellar disease. Adv Neurol 61:15–31
Westling G, Johansson RS (1984) Factors influencing the force control during precision grip. Exp Brain Res 53:277–284
Winstein CJ, Abbs JH, Petashnick D (1991) Influences of object weight and instruction on grip force adjustments. Exp Brain Res 87:465–469
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Müller, F., Dichgans, J. Dyscoordination of pinch and lift forces during grasp in patients with cerebellar lesions. Exp Brain Res 101, 485–492 (1994). https://doi.org/10.1007/BF00227341
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DOI: https://doi.org/10.1007/BF00227341