Abstract
Women often report that they smoke cigarettes to avoid weight gains and that they relapse after abstaining from tobacco because of weight gains. Men also report these concerns but to a lesser extent. This gender difference may reflect sociological and cultural pressures about physical appearance, or it may reflect sex differences in the effects of nicotine. The present research was designed to examine the effects of nicotine administration and cessation of nicotine on body weight, food consumption, and water consumption. Alzet miniosmotic pumps were implanted SC to administer saline or three different concentrations of nicotine to female Sprague-Dawley rats for 17 days. This paradigm has been used in previous studies of nicotine and body weight in male rats. Animals were used as subjects to avoid cultural factors and cognitive concerns about body weight. Nicotine administration decreased normal body weight gains and cessation of nicotine was accompanied by significant increases in body weight compared to controls. In contrast to previous studies of male rats, the nicotine-related changes in body weight were accompanied by changes in bland food and water consumption. These findings indicate that females are more sensitive than males to the effects of nicotine on body weight and feeding during and after drug administration.
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References
Bättig K, Buzzi R, Nil R (1982) Smoke yield of cigarettes and puffing behavior in men and women. Psychopharmacology 76:139–148
Beckett AH, Gorrod JW, Jenner P (1971) The effect of smoking on nicotine metabolism in vivo in man. J Pharm Pharmacol 23:62S–67S
Benowitz NL, Jacob P (1984) Daily intake of nicotine during cigarette smoking. Clin Pharmacol Ther 35:499–504
Dicken C (1978) Sex roles, smoking, and smoking cessation. J Health Soc Behav 19:324–334
Grunberg NE (1982) The effects of nicotine and cigarette smoking on food consumption and taste preferences. Addict Behav 7:317–331
Grunberg NE, Morse DE (1984) Cigarette smoking and food consumption in the United States. J Appl Soc Psychol 14:310–317
Grunberg NE, Bowen DJ, Morse DE (1984) Effects of nicotine on body weight and food consumption in rats. Psychopharmacology 83:93–98
Grunberg NE, Bowen DJ, Maycock VA, Nespor, SM (1985) The importance of sweet taste and caloric content in the effects of nicotine on specific food consumption. Psychopharmacology 87:198–203
Handelmann G, Ravizza R, Ray WJ (1980) Social dominance determines estrous entrainment among female hamsters. Horm Behav 14:107–115
Jarvis M (1985) Nicotine administration via nasal solutions. Presented at the World Congress on the Pharmacologic Treatment of Tobacco Dependence, New York City, New York
Kozlowski LT, Director J, Harford MA (1981) Tobacco dependence, restraint and time to the first cigarette of the day. Addict Behav 6:307–312
Lincoln J (1969) Weight gain after cessation of smoking. JAMA 210:1765
Page RM, Gold RS (1983) Assessing gender differences in college cigarette smoking intenders and nonintenders. JOSH 53:531–535
Rose JE, Herskovic J, Trilling Y, Jarvik ME (1985) Transdermal nicotine reduces cigarette craving and nicotine preference. Clin Pharmacol Ther 38:450–456
Rosecrans JA (1972) Brain area nicotine levels in male and female rats with different levels of spontaneous activity. Neuropharmacology 11:863–870
Russell MAH, Jarvis M, Iyer R, Feyerabend C (1980) Relation of nicotine yield of cigarettes to blood nicotine concentrations in smokers. Br Med J 5 April:972–976
Schechter MD, Cook PG (1976) Nicotine-induced weight loss in rats without an effect on appetite. Eur J Pharmacol 38:63–69
Silverstein B, Feld S, Kozlowski LT (1980) The availability of low-nicotine cigarettes as a cause of cigarette smoking among teenage females. J Health Soc Behav 21:383–388
Silverstein B, Kelly E, Swan J, Kozlowski LT (1982) Physiological predisposition toward becoming a cigarette smoker: experimental evidence for a sex difference. Addict Behav 7:83–86
Tagliacozzo R, Vaughn S (1980) Women's smoking trends and awareness of health risk. Prev Med 9:384–387
Theeuwes F, Yum SI (1977) Principles of the design and operation of generic osmotic pumps for the delivery of semisolid or liquid drug formulations. Ann Biomed Eng 4:343–353
Weizenbaum F, Kenney NJ, Adler NT (1979) Similarities in the regulatory patterns of pregnant and cycling rats. Physiol Behav 23:891–896
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Grunberg, N.E., Bowen, D.J. & Winders, S.E. Effects of nicotine on body weight and food consumption in female rats. Psychopharmacology 90, 101–105 (1986). https://doi.org/10.1007/BF00172879
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DOI: https://doi.org/10.1007/BF00172879