Skip to main content

Potential Cellular and Biochemical Mechanisms of Exercise and Physical Activity on theĀ Ageing Process

  • Chapter
  • First Online:
Biochemistry and Cell Biology of Ageing: Part II Clinical Science

Part of the book series: Subcellular Biochemistry ((SCBI,volume 91))

Abstract

Exercise in young adults has been consistently shown to improve various aspects of physiological and psychological health but we are now realising the potential benefits of exercise with advancing age. Specifically, exercise improves cardiovascular, musculoskeletal, and metabolic health through reductions in oxidative stress, chronic low-grade inflammation and modulating cellular processes within a variety of tissues. In this this chapter we will discuss the effects of acute and chronic exercise on these processes and conditions in an ageing population, and how physical activity affects our vasculature, skeletal muscle function, our immune system, and cardiometabolic risk in older adults.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abdul-Ghani MA, Tripathy D, DeFronzo RA (2006) Contributions of beta-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose. Diabetes Care 29:1130ā€“1139

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • ADA (2014) Diagnosis and classification of diabetes mellitus. Diabetes Care 37(Suppl 1):S81ā€“S90

    Google ScholarĀ 

  • Aguirre LE, Jan IZ, Fowler K et al (2014) Testosterone and adipokines are determinants of physical performance, strength, and aerobic fitness in frail, obese, older adults. Int J Endocrinol 2014:507395

    ArticleĀ  PubMedĀ  PubMed CentralĀ  CASĀ  Google ScholarĀ 

  • Aly YE, Abdou AS, Rashad MM et al (2016) Effect of exercise on serum vitamin D and tissue vitamin D receptors in experimentally induced type 2 diabetes mellitus. J Adv Res 7:671ā€“679

    ArticleĀ  CASĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Amati F, DubĆ© JJ, Coen PM et al (2009) Physical inactivity and obesity underlie the insulin resistance of ageing. Diabetes Care 32:1547ā€“1549

    ArticleĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Ari Z, Kutlu N, Uyanik BS et al (2004) Serum testosterone, growth hormone, and insulin-like growth factor-1 levels, mental reaction time, and maximal aerobic exercise in sedentary and long-term physically trained elderly males. Int J Neurosci 114:623ā€“637

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Asahara T, Murohara T, Sullivan A et al (1997) Isolation of putative progenitor endothelial cells for angiogenesis. Science 275:964ā€“966

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Asahara T, Masuda H, Takahashi T et al (1999) Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res 85:221ā€“228

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Atkinson RA, Srinivas-Shankar U, Roberts SA et al (2010) Effects of testosterone on skeletal muscle architecture in intermediate-frail and frail elderly men. J Gerontol A Biol Sci Med Sci 65A:1215ā€“1219

    ArticleĀ  CASĀ  Google ScholarĀ 

  • Bar-Shai M, Carmeli E, Ljubuncic P et al (2008) Exercise and immobilization in ageing animals: the involvement of oxidative stress and NF-ĪŗB activation. Free Rad Biol Med 44:202ā€“214

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Basu R, Breda E, Oberg AL et al (2003) Mechanisms of the age-associated deterioration in glucose tolerance: contribution of alterations in insulin secretion, action, and clearance. Diabetes 52:1738ā€“1748

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Bejma J, Ji LL (1999) Ageing and acute exercise enhance free radical generation in rat skeletal muscle. J Appl Physiol 87:465ā€“470

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Birk GK, Dawson EA, Atkinson C et al (2012) Brachial artery adaptation to lower limb exercise training: role of shear stress. J Appl Physiol 112:1653ā€“1658

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  • Bischoff HA, Borchers M, Gudat F et al (2001) In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue. Histochem J 33:19ā€“24

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Bischoff HA, Stahelin HB, Dick W et al (2003) Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res 18:343ā€“351

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Bischoff-Ferrari HA, Borchers M, Gudat F et al (2004a) Vitamin D receptor expression in human muscle tissue decreases with age. J Bone Miner Res 19:265ā€“269

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Bischoff-Ferrari HA, Dietrich T, Orav EJ et al (2004b) Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults. Am J Med 116:634ā€“639

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Black MA, Green DJ, Cable NT (2008) Exercise prevents age-related decline in nitric-oxide-mediated vasodilator function in cutaneous microvessels. J Physiol 586:3511ā€“3524

    ArticleĀ  CASĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Black MA, Cable NT, Thijssen DH et al (2009) Impact of age, sex, and exercise on brachial artery flow-mediated dilatation. Am J Physiol Heart Circ Physiol 297:H1109ā€“H1116

    ArticleĀ  CASĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Bloomer RJ, Schilling BK, Karlage RE et al (2008) Effect of resistance training on blood oxidative stress in Parkinson disease. Med Sci Sports Exerc 40:1385ā€“1389

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Bobeuf F, Labonte M, Dionne IJ et al (2011) Combined effect of antioxidant supplementation and resistance training on oxidative stress markers, muscle and body composition in an elderly population. J Nutr Health Ageing 15:883ā€“889

    ArticleĀ  CASĀ  Google ScholarĀ 

  • Breen L, Stokes KA, Churchward-Venne TA et al (2013) Two weeks of reduced activity decreases leg lean mass and induces ā€œanabolic resistanceā€ of myofibrillar protein synthesis in healthy elderly. J Clin Endocrinol Metab 98:2604ā€“2612

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Briggs AM, Cross MJ, Hoy DG et al (2016) Musculoskeletal health conditions represent a global threat to healthy ageing: a report for the 2015 World Health Organization World Report on ageing and health. Gerontologist 56:S243ā€“S255

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  • Bruyndonckx L, Hoymans VY, Frederix G et al (2014) Endothelial progenitor cells and endothelial microparticles are independent predictors of endothelial function. J Pediatr 165:300ā€“305

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Butler AE, Janson J, Bonner-Weir S et al (2003) Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52:102ā€“110

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Cannavino J, Brocca L, Sandri M et al (2014) PGC1-Ī± over-expression prevents metabolic alterations and soleus muscle atrophy in hindlimb unloaded mice. J Physiol 592:4575ā€“4589

    ArticleĀ  CASĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Carlsson AC, Arnlov J, Sundstrom J etĀ al (2016) Physical activity, obesity and risk of cardiovascular disease in middle-aged men during a median of 30 years of follow-up. Eur J Prev Cardiol 23:359ā€“365

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  • Case J, Mead LE, Bessler WK et al (2007) Human CD34+AC133+VEGFR-2+ cells are not endothelial progenitor cells but distinct, primitive hematopoietic progenitors. Exp Hematol 35:1109ā€“1118

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Castaldi A, Dodia RM, Orogo AM et al (2017) Decline in cellular function of aged mouse c-kit(+) cardiac progenitor cells. J Physiol 595:6249ā€“6262

    ArticleĀ  CASĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Castle SC (2000) Clinical relevance of age-related immune dysfunction. Clin Infect Dis 31:578ā€“585

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Ceglia L, Harris SS (2013) Vitamin D and its role in skeletal muscle. Calcif Tissue Int 92:151ā€“162

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Ceglia L, Niramitmahapanya S, da Silva Morais M et al (2013) A randomized study on the effect of vitamin D(3) supplementation on skeletal muscle morphology and vitamin D receptor concentration in older women. J Clin Endocrinol Metab 98:E1927ā€“E1935

    ArticleĀ  CASĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Celis-Morales CA, Lyall DM, Welsh P et al (2017) Association between active commuting and incident cardiovascular disease, cancer, and mortality: prospective cohort study. BMJ 357:j1456

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  • Chapuy MC, Durr F, Chapuy P (1983) Age-related changes in parathyroid hormone and 25 hydroxycholecalciferol levels. J Gerontol 38:19ā€“22

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Chen X, Liang H, Van Remmen H et al (2004) Catalase transgenic mice: characterization and sensitivity to oxidative stress. Arch Biochem Biophys 422:197ā€“210

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Chistiakov DA, Orekhov AN, Bobryshev YV (2017) Effects of shear stress on endothelial cells: go with the flow. Acta Physiol (Oxf) 219:382ā€“408

    ArticleĀ  CASĀ  Google ScholarĀ 

  • Choi J, Moon K, Jung S et al (2014) Regular exercise training increases the number of endothelial progenitor cells and decreases homocysteine levels in healthy peripheral blood. Kor J Physiol Pharmacol 18:163ā€“168

    ArticleĀ  CASĀ  Google ScholarĀ 

  • Chrissobolis S, Faraci FM (2008) The role of oxidative stress and NADPH oxidase in cerebrovascular disease. Trends Mol Med 14:495ā€“502

    ArticleĀ  CASĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Chung HY, Cesari M, Anton S et al (2009) Molecular inflammation: underpinnings of ageing and age-related diseases. Ageing Res Rev 8:18ā€“30

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Cnop M, Welsh N, Jonas JC et al (2005) Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes 54(Suppl 2):S97ā€“S107

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Cobley JN, McHardy H, Morton JP et al (2015) Influence of vitamin C and vitamin E on redox signaling: implications for exercise adaptations. Free Radic Biol Med 84:65ā€“76

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Cobley JN, Close GL, Bailey DM et al (2017) Exercise redox biochemistry: conceptual, methodological and technical recommendations. Redox Biol 12:540ā€“548

    ArticleĀ  CASĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Coleman LA, Mishina M, Thompson M et al (2016) Age, serum 25-hydroxyvitamin D and vitamin D receptor (VDR) expression and function in peripheral blood mononuclear cells. Oncotarget 7:35512ā€“35521

    PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Collaboration NRF (2016) Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4Ā·4 million participants. Lancet 387:1513ā€“1530

    ArticleĀ  Google ScholarĀ 

  • Coon PJ, Rogus EM, Drinkwater D et al (1992) Role of body fat distribution in the decline in insulin sensitivity and glucose tolerance with age. J Clin Endocrinol Metab 75:1125ā€“1132

    CASĀ  PubMedĀ  Google ScholarĀ 

  • Cruz-Jentoft AJ, Baeyens JP, Bauer JM et al (2010) Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on sarcopenia in older people. Age Ageing 39:412ā€“423

    ArticleĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Cuthbertson D, Smith K, Babraj J etĀ al (2005) Anabolic signaling deficits underlie amino acid resistance of wasting, ageing muscle. FASEB J 19:422ā€“424

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Dawson-Hughes B, Harris SS, Krall EA et al (1997) Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 337:670ā€“676

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • de Souto Barreto P, Cesari M, Andrieu S et al (2017) Physical activity and incident chronic diseases: a longitudinal observational study in 16 European countries. Am J Prev Med 52:373ā€“378

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  • Deane CS, Hughes DC, Sculthorpe N et al (2013) Impaired hypertrophy in myoblasts is improved with testosterone administration. J Ster Biochem Mol Biol 138:152ā€“161

    ArticleĀ  CASĀ  Google ScholarĀ 

  • Delmonico MJ, Harris TB, Lee JS et al (2007) Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with ageing in older men and women. J Am Geriatr Soc 55:769ā€“774

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  • Delmonico MJ, Harris TB, Visser M et al (2009) Longitudinal study of muscle strength, quality, and adipose tissue infiltration. Am J Clin Nutr 90:1579ā€“1585

    ArticleĀ  CASĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Devries MC, Breen L, Von Allmen M et al (2015) Low-load resistance training during step-reduction attenuates declines in muscle mass and strength and enhances anabolic sensitivity in older men. Physiol Rep 3:e12493

    ArticleĀ  PubMedĀ  PubMed CentralĀ  CASĀ  Google ScholarĀ 

  • Doering T, Jenkins D, Reaburn P et al (2016) Lower integrated muscle protein synthesis in masters compared with younger athletes. Med Sci Sports Exerc 48:1613ā€“1618

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Done AJ, Traustadottir T (2016) Aerobic exercise increases resistance to oxidative stress in sedentary older middle-aged adults. A pilot study. Age (Dordr) 38:505ā€“512

    ArticleĀ  CASĀ  Google ScholarĀ 

  • Duggal NA, Pollock RD, Lazarus NR et al (2018) Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood. Ageing Cell 17:e12750

    ArticleĀ  CASĀ  Google ScholarĀ 

  • Ellison G, Vicinanza C, Smith A et al (2013) Adult c-kitpos cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair. Cell 154:827ā€“842

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Eskurza I, Monahan KD, Robinson JA et al (2004) Effect of acute and chronic ascorbic acid on flow-mediated dilatation with sedentary and physically active human ageing. J Physiol 556:315ā€“324

    ArticleĀ  CASĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Evans WJ (2010) Skeletal muscle loss: cachexia, sarcopenia, and inactivity. Am J Clin Nutr 91:1123Sā€“1127S

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Fiatarone MA, Marks EC, Ryan ND et al (1990) High-intensity strength training in nonagenarians: effects on skeletal muscle. JAMA 263:3029ā€“3034

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Figueiredo PA, Powers SK, Ferreira RM et al (2009) Impact of lifelong sedentary behavior on mitochondrial function of mice skeletal muscle. J Gerontol A Biol Sci Med Sci 64A:927ā€“939

    ArticleĀ  CASĀ  PubMed CentralĀ  Google ScholarĀ 

  • Francaux M, Demeulder B, Naslain D et al (2016) Ageing reduces the activation of the mTORC1 pathway after resistance exercise and protein intake in human skeletal muscle: potential role of REDD1 and impaired anabolic sensitivity. Nutrients 8:47

    ArticleĀ  PubMed CentralĀ  CASĀ  Google ScholarĀ 

  • Frederiksen L, HĆøjlund K, Hougaard DM et al (2012) Testosterone therapy increased muscle mass and lipid oxidation in ageing men. Age 34:145ā€“156

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Furchgott R, Zawadzki J (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288:373ā€“376

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Gallagher JC (1990) The pathogenesis of osteoporosis. Bone Miner 9:215ā€“227

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Garcia LA, King KK, Ferrini MG et al (2011) 1,25(OH)2vitamin D3 stimulates myogenic differentiation by inhibiting cell proliferation and modulating the expression of promyogenic growth factors and myostatin in C2C12 skeletal muscle cells. Endocrinology 152:2976ā€“2986

    ArticleĀ  CASĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Gastaldelli A, Miyazaki Y, Pettiti M et al (2002) Metabolic effects of visceral fat accumulation in type 2 diabetes. J Clin Endocrinol Metab 87:5098ā€“5103

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Ghosh S, Lertwattanarak R, Lefort N et al (2011) Reduction in reactive oxygen species production by mitochondria from elderly subjects with normal and impaired glucose tolerance. Diabetes 60:2051ā€“2060

    ArticleĀ  CASĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Goodpaster BH, Krishnaswami S, Resnick H et al (2003) Association between regional adipose tissue distribution and both type 2 diabetes and impaired glucose tolerance in elderly men and women. Diabetes Care 26:372ā€“379

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  • Goodyear LJ, Kahn BB (1998) Exercise, glucose transport, and insulin sensitivity. Annu Rev Med 49:235ā€“261

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Green D (2005) Point: flow-mediated dilation does reflect nitric oxide-mediated endothelial function. J Appl Physiol 99:1233ā€“1234

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  • Green DJ, Jones H, Thijssen D et al (2011) Flow-mediated dilation and cardiovascular event prediction. Hypertension 57:363ā€“369

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Gumbiner B, Polonsky KS, Beltz WF et al (1989) Effects of ageing on insulin secretion. Diabetes 38:1549ā€“1556

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Hall KS, Cohen HJ, Pieper CF et al (2017) Physical performance across the adult life span: correlates with age and physical activity. J Gerontol A Biol Sci Med Sci 72:572ā€“578

    PubMedĀ  Google ScholarĀ 

  • Hamada K, Vannier E, Sacheck JM et al (2005) Senescence of human skeletal muscle impairs the local inflammatory cytokine response to acute eccentric exercise. FASEB J 19:264ā€“266

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Hamilton CA, Brosnan MJ, McIntyre M et al (2001) Superoxide excess in hypertension and ageing: a common cause of endothelial dysfunction. Hypertension 37:529ā€“534

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Harman D (1956) Ageing: a theory based on free radical and radiation chemistry. J Gerontol 11:298ā€“300

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Hawkins SA, Wiswell RA, Marcell TJ (2003) Exercise and the master athleteĀ ā€“ a model of successful ageing? J Gerontol A Biol Sci Med Sci 58:M1009ā€“M1011

    ArticleĀ  Google ScholarĀ 

  • Hayes LD, Grace FM, Sculthorpe N et al (2013) Does chronic exercise attenuate age-related physiological decline in males? Res Sports Med 21:343ā€“354

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  • Hayes LD, Sculthorpe N, Herbert P et al (2015) Resting steroid hormone concentrations in lifetime exercisers and lifetime sedentary males. Ageing Male 18:22ā€“26

    ArticleĀ  CASĀ  Google ScholarĀ 

  • Hayes LD, Herbert P, Sculthorpe NF et al (2017) Exercise training improves free testosterone in lifelong sedentary ageing men. Endocr Connect 6:306ā€“310

    ArticleĀ  CASĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Henriksen EJ (2002) Invited review: effects of acute exercise and exercise training on insulin resistance. J Appl Physiol 93:788ā€“796

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Herbert P, Hayes LD, Sculthorpe N et al (2017a) High-intensity interval training (HIIT) increases insulin-like growth factor-I (IGF-I) in sedentary ageing men but not mastersā€™ athletes: an observational study. Ageing Male 20:54ā€“59

    ArticleĀ  CASĀ  Google ScholarĀ 

  • Herbert P, Hayes LD, Sculthorpe NF et al (2017b) HIIT produces increases in muscle power and free testosterone in male masters athletes. Endocr Connect 6:430ā€“436

    ArticleĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Hoetzer GL, Van Guilder GP, Irmiger HM et al (2007) Ageing, exercise, and endothelial progenitor cell clonogenic and migratory capacity in men. J Appl Physiol 102:847ā€“852

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  • Holick MF (2007) Vitamin D deficiency. N Engl J Med 357:266ā€“281

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Holick MF, Chen TC (2008) Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 87:1080Sā€“1086S

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Hur J, Yoon C-H, Kim H-S et al (2004) Characterization of two types of endothelial progenitor cells and their different contributions to neovasculogenesis. Arterioscler Thromb Vasc Biol 24:288ā€“293

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Jackson MJ (2016) Reactive oxygen species in sarcopenia: should we focus on excess oxidative damage or defective redox signalling? Mol Asp Med 50:33ā€“40

    ArticleĀ  CASĀ  Google ScholarĀ 

  • Jackson RD, LaCroix AZ, Gass M et al (2006) Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 354:669ā€“683

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Janssen I, Heymsfield SB, Ross R (2002) Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc 50:889ā€“896

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  • Jensen J, Rustad PI, Kolnes AJ et al (2011) The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise. Front Physiol 2:112

    ArticleĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Jessup JV, Horne C, Yarandi H et al (2003) The effects of endurance exercise and vitamin E on oxidative stress in the elderly. Biol Res Nurs 5:47ā€“55

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  • Johnson ML, Irving BA, Lanza IR et al (2015) Differential effect of endurance training on mitochondrial protein damage, degradation, and acetylation in the context of ageing. J Gerontol A Biol Sci Med Sci 70:1386ā€“1393

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Kahn SE (2003) The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 46:3ā€“19

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Kahn SE, Larson VG, Beard JC et al (1990) Effect of exercise on insulin action, glucose tolerance, and insulin secretion in ageing. Am J Phys 258:E937ā€“E943

    CASĀ  Google ScholarĀ 

  • Karolkiewicz J, Michalak E, Pospieszna B et al (2009) Response of oxidative stress markers and antioxidant parameters to an 8-week aerobic physical activity program in healthy, postmenopausal women. Arch Gerontol Ger 49:e67ā€“e71

    ArticleĀ  Google ScholarĀ 

  • Khoo J, Tian H-H, Tan B et al (2013) Comparing effects of low- and high-volume moderate-intensity exercise on sexual function and testosterone in obese men. J Sex Med 10:1823ā€“1832

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Khosla S, Riggs BL (2005) Pathophysiology of age-related bone loss and osteoporosis. Endocrinol Metab Clin N Am 34:1015ā€“1030. xi

    ArticleĀ  CASĀ  Google ScholarĀ 

  • Kloppel G, Lohr M, Habich K et al (1985) Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited. Surv Synth Pathol Res 4:110ā€“125

    CASĀ  PubMedĀ  Google ScholarĀ 

  • Kommalage M, Gunawardena S (2013) Influence of age, gender, and sidedness on ulnar nerve conduction. J Clin Neurophysiol 30:98ā€“101

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  • Koopman R, Walrand S, Beelen M et al (2009) Dietary protein digestion and absorption rates and the subsequent postprandial muscle protein synthetic response do not differ between young and elderly men. J Nutr 139:1707ā€“1713

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Kumar V, Selby A, Rankin D et al (2009) Age-related differences in the doseā€“response relationship of muscle protein synthesis to resistance exercise in young and old men. J Physiol 587:211ā€“217

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Kushner E, Van Guilder G, MacEneaney O et al (2010) Ageing and endothelial progenitor cell release of proangiogenic cytokines. Age Ageing 39:268ā€“272

    ArticleĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Kushner EJ, MacEneaney OJ, Weil BR et al (2011) Ageing is associated with a proapoptotic endothelial progenitor cell phenotype. J Vasc Res 48:408ā€“414

    ArticleĀ  CASĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Laufs U, Werner N, Link A et al (2004) Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis. Circulation 109:220ā€“226

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Laufs U, Urhausen A, Werner N et al (2005) Running exercise of different duration and intensity: effect on endothelial progenitor cells in healthy subjects. Eur J Cardio Prev Rehab 12:407ā€“414

    ArticleĀ  Google ScholarĀ 

  • Lazuardi L, Jenewein B, Wolf AM et al (2005) Age-related loss of naive T cells and dysregulation of T-cell/B-cell interactions in human lymph nodes. Immunology 114:37ā€“43

    ArticleĀ  CASĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Lee I-M, Shiroma EJ, Lobelo F et al (2012) Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet 380:219ā€“229

    ArticleĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Leite CF, Lopes CS, Alves AC et al (2015) Endogenous resident c-Kit cardiac stem cells increase in mice with an exercise-induced, physiologically hypertrophied heart. Stem Cell Res 15:151ā€“164

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Leveille SG, Gray S, Lacroix AZ et al (2000) Physical inactivity and smoking increase risk for serious infections in older women. J Am Geriatr Soc 48:1582ā€“1588

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Lexell J (1995) Human ageing, muscle mass, and fiber type composition. J Gerontol A Biol Sci Med Sci 50 Spec No:11ā€“16

    CASĀ  PubMedĀ  Google ScholarĀ 

  • Lithgow H, Leggate M (2018) The effect of a single bout of high intensity intermittent exercise on glucose tolerance in non-diabetic older adults. Int J Exerc Sci 11:95ā€“105

    PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Lozano R, Naghavi M, Foreman K et al (2012) Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the global burden of disease study 2010. Lancet 380:2095ā€“2128

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  • Luk T-H, Dai Y-L, Siu C-W et al (2012) Effect of exercise training on vascular endothelial function in patients with stable coronary artery disease: a randomized controlled trial. Eur J Prev Cardiol 19:830ā€“839

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  • Luttrell M, Seawright J, Wilson E et al (2013) Effect of age and exercise training on protein: protein interactions among eNOS and its regulatory proteins in rat aortas. Eur J Appl Physiol 113:2761ā€“2768

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Makanae Y, Ogasawara R, Sato K et al (2015) Acute bout of resistance exercise increases vitamin D receptor protein expression in rat skeletal muscle. Exp Physiol 100:1168ā€“1176

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Malm C (2006) Susceptibility to infections in elite athletes: the S-curve. Scand J Med Sci Sports 16:4ā€“6

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Manfredini F, Rigolin GM, Malagoni AM et al (2009) Exercise training and endothelial progenitor cells in haemodialysis patients. J Int Med Res 37:534ā€“540

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Manini TM, Clark BC (2012) Dynapenia and ageing: an update. J Gerontol A Biol Sci Med Sci 67A:28ā€“40

    ArticleĀ  Google ScholarĀ 

  • Mann S, Beedie C, Balducci S et al (2014) Changes in insulin sensitivity in response to different modalities of exercise: a review of the evidence. Diabetes Metab Res Rev 30:257ā€“268

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Margaritelis NV, Theodorou AA, Paschalis V et al (2018) Adaptations to endurance training depend on exercise-induced oxidative stress: exploiting redox interindividual variability. Acta Physiol (Oxf) 222:e12898

    ArticleĀ  CASĀ  Google ScholarĀ 

  • Mayhan WG, Arrick DM, Sharpe GM et al (2008) Age-related alterations in reactivity of cerebral arterioles: role of oxidative stress. Microcirculation 15:225ā€“236

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Mikkelsen UR, CouppĆ© C, Karlsen A et al (2013) Life-long endurance exercise in humans: circulating levels of inflammatory markers and leg muscle size. Mech Age Dev 134:531ā€“540

    ArticleĀ  CASĀ  Google ScholarĀ 

  • Mitchell WK, Williams J, Atherton P et al (2012) Sarcopenia, dynapenia, and the impact of advancing age on human skeletal muscle size and strength; a quantitative review. Front Physiol 3:260

    ArticleĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Moore DR, Churchward-Venne TA, Witard O et al (2015) Protein ingestion to stimulate myofibrillar protein synthesis requires greater relative protein intakes in healthy older versus younger men. J Gerontol A Biol Sci Med Sci 70:57ā€“62

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Mooren FC, Kruger K (2015) Apoptotic lymphocytes induce progenitor cell mobilization after exercise. J Appl Physiol 119:135ā€“139

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Muller-Delp JM (2006) Ageing-induced adaptations of microvascular reactivity. Microcirculation 13:301ā€“314

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Murphy MP (2009) How mitochondria produce reactive oxygen species. Biochem J 417:1ā€“13

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Navarro A, Gomez C, LĆ³pez-Cepero JM et al (2004) Beneficial effects of moderate exercise on mice ageing: survival, behavior, oxidative stress, and mitochondrial electron transfer. Am J Physiol Regul Integr Comp Physiol 286:R505ā€“R511

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Newman AB, Kupelian V, Visser M et al (2006) Strength, but not muscle mass, is associated with mortality in the health, ageing and body composition study cohort. J Gerontol A Biol Sci Med Sci 61:72ā€“77

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  • Nieman DC (1994) Exercise, infection, and immunity. Int J Sports Med 15(Suppl 3):S131ā€“S141

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  • Otis JS, Niccoli S, Hawdon N et al (2014) Pro-inflammatory mediation of myoblast proliferation. PLoS One 9:e92363

    ArticleĀ  PubMedĀ  PubMed CentralĀ  CASĀ  Google ScholarĀ 

  • Pan XR, Li GW, Hu YH et al (1997) Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care 20:537ā€“544

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Paneni F, Costantino S, Cosentino F (2015) Role of oxidative stress in endothelial insulin resistance. World J Diabetes 6:326ā€“332

    ArticleĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Parise G, Brose AN, Tarnopolsky MA (2005a) Resistance exercise training decreases oxidative damage to DNA and increases cytochrome oxidase activity in older adults. Exp Gerontol 40:173ā€“180

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Parise G, Phillips SM, Kaczor JJ et al (2005b) Antioxidant enzyme activity is up-regulated after unilateral resistance exercise training in older adults. Free Rad Biol Med 39:289ā€“295

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Park D-R, Park K-H, Kim B-J et al (2015) Exercise ameliorates insulin resistance via Ca2+ signals distinct from those of insulin for GLUT4 translocation in skeletal muscles. Diabetes 64:1224ā€“1234

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Patel RS, Li Q, Ghasemzadeh N et al (2015) Circulating CD34+ progenitor cells and risk of mortality in a population with coronary artery disease. Circ Res 116:289ā€“297

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Pawelec G, Ferguson FG, Wikby A (2001) The SENIEUR protocol after 16 years. Mech Ageing Dev 122:132ā€“134

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Petersen KF, Dufour S, Savage DB et al (2007) The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. PNAS 104:12587ā€“12594

    ArticleĀ  CASĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Phillips SM (2015) Nutritional supplements in support of resistance exercise to counter age-related sarcopenia. Adv Nutr (Bethesda, MD) 6:452ā€“460

    ArticleĀ  CASĀ  Google ScholarĀ 

  • Phillips SM, Chevalier S, Leidy HJ (2016) Protein ā€œrequirementsā€ beyond the RDA: implications for optimizing health. Appl Physiol Nutr Metab 41:565ā€“572

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Pierre N, Appriou Z, Gratas-Delamarche A et al (2016) From physical inactivity to immobilization: dissecting the role of oxidative stress in skeletal muscle insulin resistance and atrophy. Free Radic Biol Med 98:197ā€“207

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Provinciali M, Moresi R, Donnini A et al (2009) Reference values for CD4+ and CD8+ T lymphocytes with naive or memory phenotype and their association with mortality in the elderly. Gerontology 55:314ā€“321

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  • Rakobowchuk M, Tanguay S, Burgomaster KA et al (2008) Sprint interval and traditional endurance training induce similar improvements in peripheral arterial stiffness and flow-mediated dilation in healthy humans. Am J Physiol Regul Integr Comp Physiol 295:R236ā€“R242

    ArticleĀ  CASĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Renko O, Tolonen A-M, RysƤ J etĀ al (2018) SDF1 gradient associates with the distribution of c-Kit+ cardiac cells in the heart. Sci Rep 8:1160

    ArticleĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Rennie MJ (2009) Anabolic resistance: the effects of ageing, sexual dimorphism, and immobilization on human muscle protein turnover. Appl Physiol Nutr Metab 34:377ā€“381

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Robson PJ, Blannin AK, Walsh NP et al (1999) Effects of exercise intensity, duration and recovery on in vitro neutrophil function in male athletes. Int J Sports Med 20:128ā€“135

    CASĀ  PubMedĀ  Google ScholarĀ 

  • Rosa EF, Silva AC, Ihara SSM et al (2005) Habitual exercise program protects murine intestinal, skeletal, and cardiac muscles against ageing. J Appl Physiol 99:1569ā€“1575

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  • Ross MD, Wekesa AL, Phelan JP et al (2014) Resistance exercise increases endothelial progenitor cells and angiogenic factors. Med Sci Sports Exerc 46:16ā€“23

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Ross MD, Malone EM, Simpson R et al (2018) Lower resting and exercise-induced circulating angiogenic progenitors and angiogenic T cells in older men. Am J Physiol Heart Circ Physiol 314:H392ā€“H402

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  • Sallam N, Laher I (2016) Exercise modulates oxidative stress and inflammation in ageing and cardiovascular diseases. Oxidative Med Cell Longev 2016:7239639

    ArticleĀ  CASĀ  Google ScholarĀ 

  • Santos-Parker JR, Strahler TR, Vorwald VM et al (2017) Habitual aerobic exercise does not protect against micro- or macrovascular endothelial dysfunction in healthy estrogen-deficient postmenopausal women. J Appl Physiol 122:11ā€“19

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Sarto P, Balducci E, Balconi G et al (2007) Effects of exercise training on endothelial progenitor cells in patients with chronic heart failure. J Cardiac Fail 13:701ā€“708

    ArticleĀ  CASĀ  Google ScholarĀ 

  • Schlager O, Giurgea A, Schuhfried O et al (2011) Exercise training increases endothelial progenitor cells and decreases asymmetric dimethylarginine in peripheral arterial disease: a randomized controlled trial. Atherosclerosis 217:240ā€“248

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Sculthorpe N, Herbert P, Grace FM (2015) Low-frequency high-intensity interval training is an effective method to improve muscle power in lifelong sedentary ageing men: a randomized controlled trial. J Am Geriatr Soc 63:2412ā€“2413

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  • Shimokata H, Muller DC, Fleg JL et al (1991) Age as independent determinant of glucose tolerance. Diabetes 40:44ā€“51

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Short KR, Vittone JL, Bigelow ML et al (2003) Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity. Diabetes 52:1888ā€“1896

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Simpson RU, Thomas GA, Arnold AJ (1985) Identification of 1,25-dihydroxyvitamin D3 receptors and activities in muscle. J Biol Chem 260:8882ā€“8891

    CASĀ  PubMedĀ  Google ScholarĀ 

  • Simpson RJ, Florida-James GD, Whyte GP et al (2006) The effects of intensive, moderate and downhill treadmill running on human blood lymphocytes expressing the adhesion/activation molecules CD54 (ICAM-1), CD18 (beta2 integrin) and CD53. Eur J Appl Physiol 97:109ā€“121

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Simpson RJ, Florida-James GD, Whyte GP et al (2007) Apoptosis does not contribute to the blood lymphocytopenia observed after intensive and downhill treadmill running in humans. Res Sports Med 15:157ā€“174

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  • Simpson RJ, Lowder TW, Spielmann G et al (2012) Exercise and the ageing immune system. Ageing Res Rev 11:404ā€“420

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Sipila S, Narici M, Kjaer M et al (2013) Sex hormones and skeletal muscle weakness. Biogerontology 14:231ā€“245

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  • Smith GI, Yoshino J, Reeds DN et al (2014) Testosterone and progesterone, but not estradiol, stimulate muscle protein synthesis in postmenopausal women. J Clin Endocrinol Metab 99:256ā€“265

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Sonnenschein K, HorvĆ”th T, Mueller M et al (2011) Exercise training improves in vivo endothelial repair capacity of early endothelial progenitor cells in subjects with metabolic syndrome. Eur J Cardio Prev Rehab 18:406ā€“414

    ArticleĀ  Google ScholarĀ 

  • Soucy KG, Ryoo S, Benjo A et al (2006) Impaired shear stress-induced nitric oxide production through decreased NOS phosphorylation contributes to age-related vascular stiffness. J Appl Physiol 101:1751ā€“1759

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Spielmann G, McFarlin BK, O'Connor DP et al (2011) Aerobic fitness is associated with lower proportions of senescent blood T-cells in man. Brain Behav Immun 25:1521ā€“1529

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  • Spielmann G, Bollard CM, Bigley AB et al (2014) The effects of age and latent cytomegalovirus infection on the redeployment of CD8+ T cell subsets in response to acute exercise in humans. Brain Behav Immun 39:142ā€“151

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Spranger J, Kroke A, Mohlig M et al (2003) Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European prospective investigation into cancer and nutrition (EPIC)-Potsdam Study. Diabetes 52:812ā€“817

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Steiner S, Niessner A, Ziegler S et al (2005) Endurance training increases the number of endothelial progenitor cells in patients with cardiovascular risk and coronary artery disease. Atherosclerosis 181:305ā€“310

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Stenholm S, Koster A, Valkeinen H et al (2016) Association of physical activity history with physical function and mortality in old age. J Gerontol A Biol Sci Med Sci 71:496ā€“501

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  • Strle K, Broussard SR, McCusker RH et al (2004) Proinflammatory cytokine impairment of insulin-like growth factor I-induced protein synthesis in skeletal muscle myoblasts requires ceramide. Endocrinology 145:4592ā€“4602

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Symons TB, Sheffield-Moore M, Mamerow MM et al (2011) The anabolic response to resistance exercise and a protein-rich meal is not diminished by age. J Nutr Health Ageing 15:376ā€“381

    ArticleĀ  CASĀ  Google ScholarĀ 

  • Taddei S, Virdis A, Ghiadoni L et al (2001) Age-related reduction of NO availability and oxidative stress in humans. Hypertension 38:274ā€“279

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Takahashi M, Miyashita M, Kawanishi N et al (2013) Low-volume exercise training attenuates oxidative stress and neutrophils activation in older adults. Eur J Appl Physiol 113:1117ā€“1126

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Talbert EE, Smuder AJ, Min K et al (2013) Immobilization-induced activation of key proteolytic systems in skeletal muscles is prevented by a mitochondria-targeted antioxidant. J Appl Physiol 115:529ā€“538

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Tang BM, Eslick GD, Nowson C et al (2007) Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet 370:657ā€“666

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Tatchum-Talom R, Martin DS (2004) Tempol improves vascular function in the mesenteric vascular bed of senescent rats. Can J Physiol Pharmacol 82:200ā€“207

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Thijssen DH, Vos JB, Verseyden C et al (2006) Haematopoietic stem cells and endothelial progenitor cells in healthy men: effect of ageing and training. Ageing Cell 5:495ā€“503

    ArticleĀ  CASĀ  Google ScholarĀ 

  • Tidball JG (2017) Regulation of muscle growth and regeneration by the immune system. Nat Rev Immunol 17:165ā€“178

    ArticleĀ  CASĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Torella D, Rota M, Nurzynska D et al (2004) Cardiac stem cell and myocyte ageing, heart failure, and insulin-like growth factor-1 overexpression. Circ Res 94:514ā€“524

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Torjesen I (2016) Global cost of physical inactivity is estimated at $67.5bn a year. BMJ 354:i4187

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  • Urbanek K, Quaini F, Tasca G et al (2003) Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy. PNAS 100:10440ā€“10445

    ArticleĀ  CASĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Utriainen T, Takala T, Luotolahti M et al (1998) Insulin resistance characterizes glucose uptake in skeletal muscle but not in the heart in NIDDM. Diabetologia 41:555ā€“559

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Van Craenenbroeck EM, Vrints CJ, Haine SE et al (2008) A maximal exercise bout increases the number of circulating CD34+/KDR+ endothelial progenitor cells in healthy subjects. Relation with lipid profile. J Appl Physiol 104:1006ā€“1013

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  • Van Craenenbroeck E, Hoymans V, Beckers P et al (2010a) Exercise training improves function of circulating angiogenic cells in patients with chronic heart failure. Bas Res Cardiol 105:665ā€“676

    ArticleĀ  CASĀ  Google ScholarĀ 

  • Van Craenenbroeck EM, Beckers PJ, Possemiers NM et al (2010b) Exercise acutely reverses dysfunction of circulating angiogenic cells in chronic heart failure. Eur Heart J 31:1924ā€“1934

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  • Veldurthy V, Wei R, Oz L et al (2016) Vitamin D, calcium homeostasis and ageing. Bone Res 4:16041

    ArticleĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Vincent HK, Bourguignon C, Vincent KR (2006) Resistance training lowers exercise-induced oxidative stress and homocysteine levels in overweight and obese older adults. Obesity 14:1921ā€“1930

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Visser M, Goodpaster BH, Kritchevsky SB et al (2005) Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons. J Gerontol A Biol Sci Med Sci 60:324ā€“333

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  • Volpi E, Mittendorfer B, Rasmussen BB et al (2000) The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly. J Clin Endocrinol Metab 85:4481ā€“4490

    CASĀ  PubMedĀ  Google ScholarĀ 

  • Wang J-S, Lee M-Y, Lien H-Y et al (2014) Hypoxic exercise training improves cardiac/muscular hemodynamics and is associated with modulated circulating progenitor cells in sedentary men. Int J Cardiol 170:315ā€“323

    ArticleĀ  PubMedĀ  Google ScholarĀ 

  • Wang P, Li CG, Qi Z et al (2015) Acute exercise induced mitochondrial H(2)O(2) production in mouse skeletal muscle: association with p(66Shc) and FOXO3a signaling and antioxidant enzymes. Oxidative Med Cell Longev 2015:536456

    Google ScholarĀ 

  • Wannamethee SG, Shaper AG, Walker M (1998) Changes in physical activity, mortality, and incidence of coronary heart disease in older men. Lancet 351:1603ā€“1608

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Webb R, Hughes MG, Thomas AW et al (2017) The ability of exercise-associated oxidative stress to trigger redox-sensitive signalling responses. Antioxidants (Basel) 6:63

    ArticleĀ  CASĀ  Google ScholarĀ 

  • Xia W-H, Li J, Su C et al (2012a) Physical exercise attenuates age-associated reduction in endothelium-reparative capacity of endothelial progenitor cells by increasing CXCR4/JAK-2 signaling in healthy men. Ageing Cell 11:111ā€“119

    ArticleĀ  CASĀ  Google ScholarĀ 

  • Xia WH, Yang Z, Xu SY et al (2012b) Age-related decline in reendothelialization capacity of human endothelial progenitor cells is restored by shear stress. Hypertension 59:1225ā€“1231

    ArticleĀ  CASĀ  PubMedĀ  Google ScholarĀ 

  • Xiao J, Xu T, Li J etĀ al (2014) Exercise-induced physiological hypertrophy initiates activation of cardiac progenitor cells. Int J Clin Exp Pathol 7:663ā€“669

    CASĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Xu X, C-N C, Arriaga EA et al (2010) Asymmetric superoxide release inside and outside the mitochondria in skeletal muscle under conditions of ageing and disuse. J Appl Physiol 109:1133ā€“1139

    ArticleĀ  CASĀ  PubMedĀ  PubMed CentralĀ  Google ScholarĀ 

  • Zhang J-M, An J (2007) Cytokines, inflammation and pain. Int Anesth Clin 45:27ā€“37

    ArticleĀ  CASĀ  Google ScholarĀ 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mark Ross .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

Ā© 2019 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Ross, M., Lithgow, H., Hayes, L., Florida-James, G. (2019). Potential Cellular and Biochemical Mechanisms of Exercise and Physical Activity on theĀ Ageing Process. In: Harris, J., Korolchuk, V. (eds) Biochemistry and Cell Biology of Ageing: Part II Clinical Science. Subcellular Biochemistry, vol 91. Springer, Singapore. https://doi.org/10.1007/978-981-13-3681-2_12

Download citation

Publish with us

Policies and ethics