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Electrophysiological Signatures of Reward Processing in Anhedonia

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Anhedonia: A Comprehensive Handbook Volume I

Abstract

Anhedonia is characterized by a reduced capacity to experience pleasure in response to rewarding stimuli and has been considered a possible candidate endophenotype in depression and schizophrenia. In this chapter we will focus on recent studies in which new electrophysiological brain measures (event-related brain potentials and oscillatory activity) have been used to understand the deficits in reward processing in anhedonic subclinical and clinical samples. The advantage of these neuroimaging techniques is that they provide time-sensitive measures that could be especially relevant to disentangle the differences between anticipatory and/or consummatory experiences of pleasure in anhedonia. Furthermore, because of the close interrelationship between reward and learning processes, we will review evidence showing how learning and reinforcement styles could influence the capacity to accurately anticipate positive rewarding experiences in anhedonics as well as in depressive patients. At the motivational level, this cognitive bias could be translated not only into an increased susceptibility to avoid potential negative events but also into a reduced tendency to seek positive experiences or rewards. This interpretation is therefore in agreement with the idea that the effects observed in anhedonia with regard reward processing are more related to anticipatory rather than consummatory processes.

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Abbreviations

ACC:

Anterior Cingulate Cortex

BOLD:

Blood-Oxygenation-Level Dependent contrast

BRS:

Brain Reward System

DBS:

Deep Brain Stimulation

ERN:

Error related negativity

ERPs:

Event-related brain potentials

FCPS:

Fawcett-Clarke Pleasure Scale

fMRI:

Functional Magnetic Resonance Imaging

FRN:

Feedback related negativity

MFN:

Medial Frontal Negativity

MDD:

Major Depressive Disorder

NAcc:

Nucleus Accumbens

OFC:

Orbitofrontal cortex

PAS:

Chapman Physical Anhedonia Scale

SAS:

Chapman Social Anhedonia Scale

SHAPS:

Snaith–Hamilton Pleasure Scale

VMPFC:

Ventro medial Prefrontal Cortex

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Acknowledgements

This research has been supported by a grant from the Spanish Government (PSI2011-29219 to A.R.F.) and the Catalan Government (Generalitat de Catalunya, 2009 SGR 93).

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Authors and Affiliations

  1. Sant Pere Claver Health Foundation, Mental Health Services, Barcelona, 08004, Spain

    Aida Mallorquí

  2. Cognition and Brain Plasticity Group, ICREA and Department of Basic Psychology (Campus de Bellvitge) [Bellvitge Biomedical Research Institute], IDIBELL, L’Hospitalet de Llobregat, University of Barcelona, Barcelona, 08097, Spain

    Gonçalo Padrao & Antoni Rodriguez-Fornells

  3. Department of Basic Psychology, Faculty of Psychology, Campus Bellvitge, University of Barcelona, L’Hospitalet de Llobregat, Barcelona, 08097, Spain

    Gonçalo Padrao & Antoni Rodriguez-Fornells

  4. Catalan Institution for Research and Advanced Studies, ICREA, Barcelona, Spain

    Antoni Rodriguez-Fornells

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  1. Aida Mallorquí
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  2. Gonçalo Padrao
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  3. Antoni Rodriguez-Fornells
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Correspondence to Antoni Rodriguez-Fornells .

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  1. Haifa & Sha'ar Menashe Mental Health Center, Israel Institute of Technology, Hadera, Israel

    Michael S. Ritsner

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Mallorquí, A., Padrao, G., Rodriguez-Fornells, A. (2014). Electrophysiological Signatures of Reward Processing in Anhedonia. In: Ritsner, M. (eds) Anhedonia: A Comprehensive Handbook Volume I. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8591-4_11

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