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Hypertrophic Cardiomyopathy

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Cardiovascular Genetics for Clinicians

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 239))

Abstract

Up till a decade ago, diagnostic identification of acquired or hereditary cardiac diseases was based upon clinical observations and pedigree analysis and supported by instrumental and biochemical diagnostic tests. The molecular basis of the majority of these disorders was grossly unknown or speculative. In the last ten years, rapidly evolving and innovative strategies in molecular biology and genetics have completely changed this scenario. Families with well-documented hereditary disorders, sometimes known for several decades, appeared very attractive to start the search for the causative molecular defect. Using linkage analysis with DNA markers (DNA variants scattered along the genome), it became possible to search for linkage of particular markers and the disease-causing locus in a given family. Once the risk locus was identified, several strategies to identify the gene defect could be applied. By comparing families with identical genetic defects and by an inventory on the clinical features of all affected individuals it may be possible to establish genotype-phenotype correlations, which in turn can lead to an exact diagnosis.

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Authors
  1. L. Carrier
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  2. R. J. E. Jongbloed
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  3. H. J. M. Smeets
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  4. P. A. Doevendans
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Editors and Affiliations

  1. Academic Hospital Maastricht, Maastricht, The Netherlands

    P. A. Doevendans

  2. Academic Medical Center, Amsterdam, The Netherlands

    A. A. M. Wilde

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Carrier, L., Jongbloed, R.J.E., Smeets, H.J.M., Doevendans, P.A. (2001). Hypertrophic Cardiomyopathy. In: Doevendans, P.A., Wilde, A.A.M. (eds) Cardiovascular Genetics for Clinicians. Developments in Cardiovascular Medicine, vol 239. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-1019-1_12

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  • DOI: https://doi.org/10.1007/978-94-010-1019-1_12

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