Zusammenfassung
Schon lange weiß man, dass psychische Störungen innerhalb von Familien gehäuft vorkommen. Dies bedeutet zunächst nichts anderes, als dass Personen aus derselben Familie häufiger an derselben Störung leiden als Personen, die nicht miteinander verwandt sind. Kann man bei bestimmten Merkmalen (z. B. bestimmten Störungsbildern) eine solche familiäre Häufung (sog. Aggregation) beobachten, so liegt der Schluss nahe, dass diese – über welche Mechanismen oder Prozesse auch immer – innerhalb der Familie weitergegeben bzw. übertragen werden. Unter familiärer Transmission psychischer Störungen versteht man daher die familiäre Weitergabe psychischer Störungen zwischen den Generationen.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Bagot, R.C., van Hasselt, F.N., Champagne, D.L., Meaney, M.J., Krugers, H.J. & Joels, M. (2009). Maternal care determines rapid effects of stress mediators on synaptic plasticity in adult rat hippocampal dentate gyrus. Neurobiology of Learning & Memory, 92(3), 292–300.
Caspi, A., Sugden, K., Moffit, T.E., Taylor, A., Craig, I.W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A. & Poulton, R. (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HAT Gene. Science, 301, 386–389.
Faraone, A.V., Tsuang, D.D. & Tsuang, D.W. (1999). Genetics of mental disorders. A guide for students, clinicians, and researchers. New York: Guilford.
Keck, M.E., Ohl, F., Holsboer F. & Müller, M.B. (2005). Listening to mutant mice: a spotlight on the role of CRF/CRF receptor systems in affective disorders. Neuroscience and Biobehavioral Reviews, 29, 867– 889.
Kendler, K.S., Gardner, C.O., Annas, P., Neale, M.C., Eaves, L.J. & Lichtenstein, P. (2008). Evidence for a developmentally dynamic genome. Archives of General Psychiatry, 65, 421–429.
Kendler, K.S., Karkowski, L.M. & Prescott, C.A. (1999). Fears and phobias: Reliability and heritability. Psychological Medicine, 29, 539–553.
Kendler, K.S., Neale, M.C., Kessler, R.C. & Eaves, L.J. (1992). A populationbased twin study of major depression in women – the impact of varying definitions of illness. Archives of General Psychiatry, 49, 257–266.
Kendler, K.S., Neale, M.C., Kessler, R.C., Heath, A.C. & Eaves, L.J. (1993). Major depression and phobias: The genetic and environmental sources of comorbidity. Psychological Medicine, 23, 361–371.
Kendler, K.S., Kuhn, J.W., Vittum, J., Prescott, C.A. & Riley, B. (2005). The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression. Archives of General Psychiatry, 62, 529–535.
Kendler, K.S., Prescott, C.A., Jacobson, K., Myers, J. & Neale, M. C. (2002). The joint analysis of personal interview and family history diagnoses: Evidence for validity of diagnosis and increased heritability estimates. Psychological Medicine, 32(5), 829–845.
Knappe, S., Lieb, R., Beesdo, K., Fehm, L., Low, N.C.P., Gloster, A.T., & Wittchen, H.-U. (2009). The role of parental psychopathology and family environment for social phobia in the first three decades of life. Depression and Anxiety 26, 363–370.
Klein, D.N., Lewinsohn, P.M., Seeley, J.R. & Rohde, P. (2001). A family study of major depressive disorder in a community sample of adolescents. Archives of General Psychiatry, 58, 13–20.
Kety, S.S., Wender, P.H., Jacobson, B., Ingraham, L.J., Jannson, L., Faber, B. & Kinney, D.K. (1994). Mental illness in the biological and adoptive relatives of schizophrenic adoptees. Archives of General Psychiatry, 51, 442–455.
Lieb, R., Wittchen, H.-U., Höfler, M., Fuetsch, M., Stein, M. & Merikangas, K.R. (2000). Parental psychopathology, parenting styles and the risk of social phobia in offspring: A prospective-longitudinal community study. Archives of General Psychiatry, 57, 859–866.
Lieb, R., Isensee, B., Höfler, M., Pfister, H. & Wittchen, H.-U. (2002). Parental major depression and the risk of depressive and other mental disorders in offspring: A prospective-longitudinal community study. Archives of General Psychiatry, 59, 365–374.
Maier, W., Zobel, A. & Schwab, S. (2007). Genetik psychischer Störungen. In: H.-J. Möller, G. Laux & H.-P. Kapfhammer (Hrsg). Psychiatrie und Psychotherapie(3. vollst. neu bearb. und aktual. Aufl., S. 71–108). Berlin, Heidelberg: Springer
McGowan, P.O., Sasaki, A., D‘Alessio, A.C., Dymov, S., Labonte, B., Szyf, M., Turecki, G. & Meaney, M. J. (2009). Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nature Neuroscience, 12(3), 342–348.
Meaney, M.J. (2001) Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. Annual Review of Neuroscience, 24, 1161–1192.
Merikangas, K.R & Low, N.C.P. (2005). Genetic epidemiology of anxiety disorders. In F. Holsboer & A. Ströhle (Eds.), Handbook of experimental pharmacology. Anxiety and anxiolytic drugs(pp. 163–179). Berlin, Heidelberg, New York: Springer.
Moffitt, T.E., Caspi, A. & Rutter, M. (2005). Strategy for investigating interactions between measured genes and measured environments. Archives of General Psychiatry, 62, 473–481.
Müller, M.B. & Keck, M.E. (2002). Genetically engineered mice for studies of stress-related clinical conditions. Journal of Psychiatric Research, 36, 53–76.
Plomin, R., DeFries, J.C., McClearn, G.E. & Rutter, M. (1999). Gene, Umwelt und Verhalten. Einführung in die Verhaltensgenetik. Bern: Huber.
Risch, N., Herrell, R., Lehner, T. et al. (2009). Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA, 301(23), 2462–2471.
Rothman, K J. & Greenland, S. (1998). Modern epidemiology(2nd ed.). Philadelphia: Lippincott-Raven.
Rutter, M., Thapar, A. & Pickles, A. (2009). Gene-environment-interactions: Biologically valid pathway or artifact? Archives of General Psychiatry, 66(12), 1287–1289.
Souery, D., Lipp, O., Mahieu, B., Mendelbaum, K., DeMartelaer, V., Van-Broeckhoven, C. & Mendlewicz, J. (1996). Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DA.T.1, and TH genes. American Journal of Medical Genetics, 67, 551–555.
Sullivan, P.F., Neale, M.C. & Kendler, K.S. (2000). Genetic epidemiology of major depression: Review and meta-analysis. American Journal of Psychiatry, 157, 1552–1562.
Warner, V., Weissman, M., Mufson, L. & Wickramaratne, P.J. (1999). Grandparents, parents, and children at high-risk for depression: a three generation study. Journal of the American Academy of Child and Adolescent Psychiatry, 38, 289–296.
Weissman, M.M., Wickramarathe, P., Nomura, Y., Warner, V., Verdeli, H., Pilowsky, D.J., Grillon, Ch. & Bruder, G. (2005). Families at high and low risk for depression. A 3-generation study. Archives of General Psychiatry, 62, 29–36.
Wilhelm, K., Mitchell, P. B., Niven, H., Finch, A., Wedgwood, L. et al. (2006). Life events, first depression onset and the serotonin transporter gene. British Journal of Psychiatry, 188, 210–215.
Zobel, A. & Maier, W. (2004). Endophänotypen – ein neues Konzept zur biologischen Charakterisierung psychischer Störungen. Nervenarzt, 75, 205–214.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Lieb, R., Knappe, S. (2011). Familiäre Transmission psychischer Störungen. In: Wittchen, HU., Hoyer, J. (eds) Klinische Psychologie & Psychotherapie. Springer-Lehrbuch. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-13018-2_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-13018-2_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-13017-5
Online ISBN: 978-3-642-13018-2
eBook Packages: Humanities, Social Science (German Language)