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Psychophysical Testing of Human Olfactory Function

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Book cover Springer Handbook of Odor

Part of the book series: Springer Handbooks ((SHB))

Abstract

This chapter is an up-to-date review of psychophysical means for testing the human sense of smell. Strengths and weaknesses of major psychophysical paradigms are discussed, including ones associated with the measurement of odor detection, discrimination, identification, memory and both suprathreshold intensity and pleasantness assessment. Factors that influence olfactory test results are discussed in detail, including the influences of test parameters, such as test length, on test reliability. It is pointed out that non-forced-choice tests, unlike forced–choice tests, are incapable of discerning subject biases and malingering. Issues related to the comparison and interpretation of test results from nominally disparate tests that differ in sensitivity, reliability, operational demands, and other factors are discussed.

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Abbreviations

2-D:

two-dimensional

3-D:

three-dimensional

JND:

just noticeable difference

UPSIT:

University of Pennsylvania smell identification test

References

  1. E.H. Weber: De Pulsu, Resorptione, Auditu et Tactu: Annotationes Anatomicae et Physiologiae (Koehler, Leipzig 1834)

    Google Scholar 

  2. G.T. Fechner: Elemente der Psychophysik (Breitkopf and Harterl, Leipzig 1860)

    Google Scholar 

  3. L.L. Thurstone: A law of comparative judgment, Psychol Rev. 34, 273–286 (1927)

    Article  Google Scholar 

  4. S.S. Stevens: To honor Fechner and repeal his law – A power function, not a log function, describes operating characteristic of a sensory system, Science 133, 80–84 (1961)

    Article  CAS  Google Scholar 

  5. D.R. Peryam, P.J. Pilgrim: Hedonic scale method for measuring food preferences, Food Technol. 11, 9–14 (1957)

    Google Scholar 

  6. E.G. Boring: Sensation and Perception in the History of Experimental Psychology (Appleton-Century-Crofts, New York 1942)

    Google Scholar 

  7. R.L. Doty: Introduction and historical perspective. In: Handbook of Olfaction and Gustation, ed. by R.L. Doty (Marcel Dekker, New York 2003) pp. xv–xlv

    Chapter  Google Scholar 

  8. G. Ekman, L. Sjoeberg: Scaling, Annu. Rev. Psychol. 16, 451–474 (1965)

    Article  CAS  Google Scholar 

  9. T. Engen: The Perception of Odors (Academic Press, New York 1982)

    Google Scholar 

  10. G.A. Gescheider: Psychophysics: Method and Theory (Lawrence Erlbaum, Hillsdale 1976)

    Google Scholar 

  11. J.P. Guilford: Psychometric Methods (McGraw-Hill, New York 1954)

    Google Scholar 

  12. E.P. Koster: Human psychophysics in olfaction. In: Methods in Olfactory Research, ed. by D.G. Moulton, A. Turk, J.W. Johnston Jr. (Academic, London 1975) pp. 345–374

    Google Scholar 

  13. L.E. Marks: Sensory Processes (Academic, New York 1974)

    Google Scholar 

  14. D.J. Murray: A perspective for viewing the history of psychophysics, Behav. Brain Sci. 16, 115–186 (1993)

    Article  Google Scholar 

  15. W.P. Tanner Jr., J.A. Swets: A decision-making theory of visual detection, Psychol. Rev. 61, 401–409 (1954)

    Article  Google Scholar 

  16. E. von Skramlik: Handbuch der Physiologie der Niederen Sinne (Georg Thieme, Leipzig 1926)

    Google Scholar 

  17. H. Zwaardemaker: Die Physiologie des Geruchs (W. Engelmann, Leipzig 1895)

    Google Scholar 

  18. H.T. Lawless, H. Heymann: Sensory Evaluation of Food: Principles and Practice (Springer, New York 2010)

    Book  Google Scholar 

  19. H. Zwaardemaker: On measurement of the sense of smell in clinical examination, Lancet I, 1300–1302 (1889)

    Article  Google Scholar 

  20. R.L. Doty, T.P. Gregor, R.G. Settle: Influence of intertrial interval and sniff-bottle volume on phenyl ethyl alcohol odor detection thresholds, Chem. Senses 11, 259–264 (1986)

    Article  CAS  Google Scholar 

  21. R.A. Frank, M.F. Dulay, R.C. Gesteland: Assessment of the sniff magnitude test as a clinical test of olfactory function, Physiol. Behavior. 78, 195–204 (2003)

    Article  CAS  Google Scholar 

  22. S. Nordin, A. Bramerson, E. Liden, M. Bende: The Scandinavian odor-identification test: Development, reliability, validity and normative data, Acta Otolaryngol. 118, 226–234 (1998)

    Article  CAS  Google Scholar 

  23. G.H. Cheesman, M.J. Townsend: Further experiments on the olfactory thresholds of pure chemical substances using the sniff-bottle method, Quart. J. Exp. Psychol. 8, 8–14 (1956)

    Article  Google Scholar 

  24. M. Samochocki, A. Hoffle, A. Fehrenbacher, R. Jostock, J. Ludwig, C. Christner, M. Radina, M. Zerlin, C. Ullmer, E.F. Pereira, H. Lubbert, E.X. Albuquerque, A. Maelicke: Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors, J. Pharmacol. Exp. Ther. 305, 1024–1036 (2003)

    Article  CAS  Google Scholar 

  25. F.N. Jones: The reliability of olfactory thresholds obtained by sniffing, Am. J. Psychol. 68, 289–290 (1955)

    Article  CAS  Google Scholar 

  26. H.S. Koelega: Olfaction and sensory asymmetry, Chem. Senses Flav. 4, 89–95 (1979)

    Article  CAS  Google Scholar 

  27. P. Green, G. Iverson: Exaggeration of anosmia in 80 litigating head injury cases, Arch. Clin. Neuropsychol. 13, 138 (1998)

    Article  Google Scholar 

  28. S. Saito, S. Ayabe-Kanamura, Y. Takashima, N. Gotow, N. Naito, T. Nozawa, M. Mise, Y. Deguchi, T. Kobayakawa: Development of a smell identification test using a novel stick-type odor presentation kit, Chem. Senses 31, 379–391 (2006)

    Article  Google Scholar 

  29. G. Semb: The detectability of the odor of butanol, Percept. Psychophys. 4, 335–340 (1968)

    Article  Google Scholar 

  30. B. Toyota, T. Kitamura, S.F. Takagi: Olfactory Disorders – Olfactometry and Therapy (Igaku-Shoin, Tokyo 1978)

    Google Scholar 

  31. T.M. Davidson, C. Murphy: Rapid clinical evaluation of anosmia. The alcohol sniff test, Arch. Otolaryngol. Head Neck Surg. 123, 591–594 (1997)

    Article  CAS  Google Scholar 

  32. T. Hummel, B. Sekinger, S.R. Wolf, E. Pauli, G. Kobal: Sniffin sticks: Olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold, Chem. Senses 22, 39–52 (1997)

    Article  CAS  Google Scholar 

  33. H.R. Briner, D. Simmen: Smell diskettes as screening test of olfaction, Rhinology 37, 145–148 (1999)

    CAS  Google Scholar 

  34. J.E. Amoore, B.G. Ollman: Practical test kits for quantitatively evaluating the sense of smell, Rhinology 21, 49–54 (1983)

    CAS  Google Scholar 

  35. W.S. Cain, J.F. Gent, R.B. Goodspeed, G. Leonard: Evaluation of olfactory dysfunction in the Connecticut chemosensory clinical research center, Laryngoscope 98, 83–88 (1988)

    Article  CAS  Google Scholar 

  36. R.L. Doty: Odor Threshold Test Administration Manual (Sensonics, Haddon Hts., NJ 2000)

    Google Scholar 

  37. D.G. Guadagni, R.G. Buttery, S. Okano: Odour thresholds of some organic compounds associated with food flavours, J. Food Sci. Agri. 14, 761–765 (1963)

    Article  CAS  Google Scholar 

  38. S. Nordin, A. Bramerson, E. Liden, M. Bende: The Scandinavian odor-identification test: Development, reliability, validity and normative data, Acta Otolaryngol. 118, 226–234 (1999)

    Google Scholar 

  39. C.A. Elsberg, I. Levy: The sense of smell: I. A new and simple method of quantitative olfactometry, Bull. Neurol. Inst. 4, 5–19 (1935), N.Y.

    Google Scholar 

  40. K. Ikeda, K. Tabata, T. Oshima, H. Nishikawa, H. Hidaka, T. Takasaka: Unilateral examination of olfactory threshold using the jet stream olfactometer, Auris Nasus Larynx 26, 435–439 (1999)

    Article  CAS  Google Scholar 

  41. E.L. Cameron, R.L. Doty: Odor identification testing in children and young adults using the smell wheel, Int. J. Pediatr. Otorhinolaryngol. 77, 346–350 (2013)

    Article  Google Scholar 

  42. R.L. Doty, P. Shaman, M. Dann: Development of the University of Pennsylvania smell identification test: A standardized microencapsulated test of olfactory function, Physiol. Behav. 32, 489–502 (1984)

    Article  CAS  Google Scholar 

  43. R.L. Doty: The Smell Identification Test Administration Manual – 3rd Edition (Sensonics, Haddon Hts., NJ 1995)

    Google Scholar 

  44. H. Fujio, K. Doi, S. Hasegawa, T. Kobayakawa, K. Nibu: Evaluation of card-type odor identification test for Japanese patients with olfactory disturbance, Ann. Otol. Rhinol. Laryngol. 121, 413–418 (2012)

    Article  Google Scholar 

  45. R.L. Doty, D.A. Deems, R.E. Frye, R. Pelberg, A. Shapiro: Olfactory sensitivity, nasal resistance and autonomic function in patients with multiple chemical sensitivities, Arch. Otolaryngol. Head Neck Surg. 114, 1422–1427 (1988)

    Article  CAS  Google Scholar 

  46. K. Springer: Combustion odors – A case study. In: Human Responses to Environmental Odors, ed. by A. Turk, J.W. Johnston Jr., D.G. Moulton (Academic Press, New York 1974) pp. 227–262

    Google Scholar 

  47. J.D. Prah, S.B. Sears, J.C. Walker: Modern approaches to air dilution olfactometry. In: Handbook of Olfaction and Gustation, ed. by R.L. Doty (Marcel Dekker, New York 1995) pp. 227–255

    Google Scholar 

  48. G. Kobal, K.H. Plattig: Objective olfactometry: Methodological annotations for recording olfactory EEG-responses from the awake human, EEG EMG Z. Elektroenzephalogr. Elektromyogr. Verwandte. Geb. 9, 135–145 (1978)

    CAS  Google Scholar 

  49. B.N. Johnson, N. Sobel: Methods for building an olfactometer with known concentration outcomes, J. Neurosci. Meth. 160, 231–245 (2007)

    Article  Google Scholar 

  50. T.S. Lorig, D.G. Elmes, D.H. Zald, J.V. Pardo: A computer-controlled olfactometer for fMRI and electrophysiological studies of olfaction, Behav. Res. Meth. Instr. Comp. 31, 370–375 (1999)

    Article  CAS  Google Scholar 

  51. P.H. Punter: Measurement of human olfactory thresholds for several groups of structurally related compounds, Chem. Senses 7, 215–235 (1983)

    Article  CAS  Google Scholar 

  52. R. Schmidt, W.S. Cain: Making scents: Dynamic olfactometry for threshold measurement, Chem. Senses 35, 109–120 (2010)

    Article  Google Scholar 

  53. J.C. Walker, D.B. Kurtz, F.M. Shore, M.W. Ogden, J.H. Reynolds: Apparatus for the automated measurement of the responses of humans to odorants, Chem. Senses 15, 165–177 (1990)

    Article  Google Scholar 

  54. B.M. Wenzel: Techniques in olfactometry: A critical review of the last one hundred years, Psychol. Bull. 45, 231–247 (1948)

    Article  CAS  Google Scholar 

  55. B. Berglund, L. Hoegman, M. Olsson: The Combined Effect of Formaldehyde and Radiant Heat on Odor Intensity and Sensory Irritation, Reports from the Department of Psychology, Vol. 681 (University of Stockholm, Stockholm 1988)

    Google Scholar 

  56. P. Dalton, C.J. Wysocki, M.J. Brody, H.J. Lawley: The influence of cognitive bias on the perceived odor, irritation and health symptoms from chemical exposure, Int. Arch. Occup. Environ. Health 69, 407–417 (1997)

    Article  CAS  Google Scholar 

  57. H.R. Blackwell: Psychophysical Thresholds: Experimental Studies of Methods of Measurement (University of Michigan Press, Ann Arbor 1953)

    Google Scholar 

  58. R.L. Doty: Olfactory psychophysics. In: Chemistry of Taste: Mechanisms, Behaviors and Mimics, ed. by P. Given, D. Paredes (American Chemical Society, Washington 2003) pp. 123–139

    Google Scholar 

  59. R.L. Doty: Intranasal trigeminal detection of chemical vapors by humans, Physiol. Behav. 14, 855–859 (1975)

    Article  CAS  Google Scholar 

  60. T.N. Cornsweet: The staircase-method in psychophysics, Am. J. Psychol. 75, 485–491 (1962)

    Article  CAS  Google Scholar 

  61. R.M. Pangborn, H.W. Berg, E.B. Roessler, A.D. Webb: Influence of methodology on olfactory response, Percept. Mot. Skills 18, 91–103 (1964)

    Article  CAS  Google Scholar 

  62. R.L. Doty, J.M. Diez, S. Turnacioglu, D.A. McKeown, J. Gledhill, K. Armstrong, W.W. Lee: Influences of feedback and ascending and descending trial presentations on perithreshold odor detection performance, Chem. Senses 28, 523–526 (2003)

    Article  Google Scholar 

  63. Sensonics, Inc.: http://www.sensonics.com

  64. J.D. Pierce Jr., R.L. Doty, J.E. Amoore: Analysis of position of trial sequence and type of diluent on the detection threshold for phenyl ethyl alcohol using a single staircase method, Percept. Mot. Skills 82, 451–458 (1996)

    Article  Google Scholar 

  65. T. Tsukatani, T. Miwa, M. Furukawa, R.M. Costanzo: Detection thresholds for phenyl ethyl alcohol using serial dilutions in different solvents, Chem. Senses 28, 25–32 (2003)

    Article  CAS  Google Scholar 

  66. K.S. Brown, C.M. MacLean, R.R. Robinette: The distribution of the sensitivity to chemical odors in man, Human Biol. 40, 456–472 (1968)

    CAS  Google Scholar 

  67. J.C. Stevens, W.S. Cain, R.J. Burke: Variability of olfactory thresholds, Chem. Senses 13, 643–653 (1988)

    Article  CAS  Google Scholar 

  68. M. Yoshida: Correlation analysis of detection threshold data for standard test odors, Bull. Fac. Sci. Eng. Cho. Univ. 27, 343–353 (1984)

    Google Scholar 

  69. R.L. Doty, D.A. McKeown, W.W. Lee, P. Shaman: A study of the test-retest reliability of ten olfactory tests, Chem. Senses 20, 645–656 (1995)

    Article  CAS  Google Scholar 

  70. R.L. Doty: Olfactory system. In: Smell and Taste in Health and Disease, ed. by T.V. Getchell, R.L. Doty, L.M. Bartoshuk, J.B. Snow Jr. (Raven Press, New York 1991) pp. 175–203

    Google Scholar 

  71. E.A. Gamble: The applicability of Weber’s law to smell, Am. J. Psychol. 39, 169–200 (1898)

    Google Scholar 

  72. J. Hermanides: Over de Constanten der in de Olfactometrie Gebruiklijke negen Standaardgeuren (Oosthoek, Utrecht 1909) pp. 58–59

    Google Scholar 

  73. M.J. Zigler, A.H. Holoway: Differential sensitivity as determined by the amount of olfactory substance, J. Gen. Psychol. 12, 372–382 (1935)

    Article  Google Scholar 

  74. H. Stone, J.J. Bosley: Olfactory discrimination and Weber’s Law, Percept. Mot. Skills 20, 657–665 (1965)

    Article  CAS  Google Scholar 

  75. B.M. Slotnick, J.E. Ptak: Olfactory intensity-difference thresholds in rats and humans, Physiol. Behav. 19, 795–802 (1977)

    Article  CAS  Google Scholar 

  76. W.S. Cain: Differential sensitivity for smell: Noise at the nose, Science 195, 796–798 (1977)

    Article  CAS  Google Scholar 

  77. W.S. Cain: Odor magnitude–coarse versus fine-grain, Percept. Psychophys. 22, 545–549 (1977)

    Article  Google Scholar 

  78. R.L. Doty: In: Mammalian Olfaction, Reproductive Processes and Behavior, ed. by R.L. Doty (Academic Press, New York 1976)

    Google Scholar 

  79. R.L. Doty, P.J. Snyder, G.R. Huggins, L.D. Lowry: Endocrine, cardiovascular and psychological correlates of olfactory sensitivity changes during the human menstrual cycle, J. Comp. Physiol. Psychol. 95, 45–60 (1981)

    Article  CAS  Google Scholar 

  80. J. Brown: Recognition assessed by rating and ranking, Br. J. Psychol. 65, 13–22 (1974)

    Article  Google Scholar 

  81. P.W. Frey, J.A. Colliver: Sensitivity and responsivity measures for discrimination learning, Learning and Motivation 4, 327–342 (1973)

    Article  Google Scholar 

  82. M. O’Mahony, L. Gardner, D. Long, C. Heintz, B. Thompson, M. Davies: Salt taste detection: An R-index approach to signal-detection measurements, Perception 8, 497–506 (1979)

    Article  Google Scholar 

  83. J.B. Grier: Nonparametric indexes for sensitivity and bias–computing formulas, Psychol. Bull. 75, 424–429 (1971)

    Article  CAS  Google Scholar 

  84. W. Hodos: Nonparametric index of response bias for use in detection and recognition experiments, Psychol. Bull. 74, 351–354 (1970)

    Article  Google Scholar 

  85. N.A. Macmillan, C.D. Creelman: Triangles in ROC space: History and theory of nonparametric measures of sensitivity and response bias, Psychonomic Bull. Rev. 3, 164–170 (1996)

    Article  CAS  Google Scholar 

  86. H. Potter, N. Butters: An assessment of olfactory deficits in patients with damage to prefrontal cortex, Neuropsychologia 18, 621–628 (1980)

    Article  CAS  Google Scholar 

  87. H. Eichenbaum, T.H. Morton, H. Potter, S. Corkin: Selective olfactory deficits in case H.M, Brain 106, 459–472 (1983)

    Article  Google Scholar 

  88. M. O’Mahony: Short-cut signal detection measures for sensory analysis, J. Food Sci. 44, 302–303 (1979)

    Article  Google Scholar 

  89. C.K. Rovee, R.Y. Cohen, W. Shlapack: Life-span stability in olfactory sensitivity, Dev. Psychol. 11, 311–318 (1975)

    Article  Google Scholar 

  90. R.L. Doty, R. Smith, D.A. McKeown, J. Raj: Tests of human olfactory function: Principal components analysis suggests that most measure a common source of variance, Percept. Psychophys. 56, 701–707 (1994)

    Article  CAS  Google Scholar 

  91. P. McReynolds, K. Ludwig: On the history of rating scales, Personal. Individ. Diff. 8, 281–283 (1987)

    Article  Google Scholar 

  92. P.T. Young: Constancy of affective judgment to odors, J. Exp. Psychol. 6, 182–191 (1923)

    Article  Google Scholar 

  93. L.M. Bartoshuk, K. Fast, D.J. Snyder: Differences in our sensory–Invalid comparisons with labeled scales, Curr. Dir. Psychol. Sci. 14, 122–125 (2005)

    Article  Google Scholar 

  94. G. Borg: A category scale with ratio properties for intermodal and interindividual comparisons. In: Psychophysical Judgment and the Process of Perception, ed. by H.G. Geissler, P. Penzold (VEG Deutscher Verlag Der Wissenschaften, Berlin 1982) pp. 25–34

    Google Scholar 

  95. G. Neely, G. Ljunggren, C. Sylven, G. Borg: Comparison between the visual analogue scale (VAS) and the category ratio scale (CR-10) for the evaluation of leg exertion, Int. J. Sport. Med. 13, 133–136 (1992)

    Article  CAS  Google Scholar 

  96. B.G. Green, P. Dalton, B. Cowart, G. Shaffer, K. Rankin, J. Higgins: Evaluating the Labeled Magnitude Scale for measuring sensations of taste and smell, Chem. Senses 21, 323–334 (1996)

    Article  CAS  Google Scholar 

  97. S.S. Stevens, E.H. Galanter: Ratio scales and category scales for a dozen perceptual continua, J. Exp. Psychol. 54, 377–411 (1957)

    Article  CAS  Google Scholar 

  98. N.H. Anderson: Functional measurement and psychophysical judgment, Psychol Rev. 77, 153–170 (1970)

    Article  CAS  Google Scholar 

  99. M.J. Hjermstad, P.M. Fayers, D.F. Haugen, A. Caraceni, G.W. Hanks, J.H. Loge, R. Fainsinger, N. Aass, S. Kaasa: Studies comparing numerical rating scales, verbal rating scales and visual analogue scales for assessment of pain intensity in adults: A systematic literature review, J. Pain Symptom Manage. 41, 1073–1093 (2011)

    Article  Google Scholar 

  100. C.C. Preston, A.M. Colman: Optimal number of response categories in rating scales: Reliability, validity, discriminating power and respondent preferences, Acta Psychol. 104, 1–15 (2000)

    Article  CAS  Google Scholar 

  101. R.L. Doty: An examination of relationships between the pleasantness, intensity and concentration of 10 odorous stimuli, Percept. Psychophys. 17, 492–496 (1975)

    Article  Google Scholar 

  102. R.L. Doty: An examination of relationships between the pleasantness, intensity, and concentration of 10 odorous stimuli, Percept. Psychophys. 17, 492–496 (1975)

    Article  Google Scholar 

  103. F.N. Jones: Subjective scales of intensity for the three odors, Am. J. Psychol. 71, 423–425 (1958)

    Article  CAS  Google Scholar 

  104. P. Overbosch: A theoretical model for perceived intensity in human taste and smell as a function of time, Chem. Senses 11, 315–329 (1986)

    Article  Google Scholar 

  105. H.T. Lawless, G.T. Malone: A comparison of rating scales: Sensitivity, replicates and relative measurement, J. Sensory Studies 1, 155–174 (1986)

    Article  Google Scholar 

  106. H.T. Lawless, G.T. Malone: The discrimination efficiency of common scaling methods, J. Sensory Studies 1, 85–98 (1986)

    Article  Google Scholar 

  107. J.C. Baird, C. Lewis, D. Romer: Relative frequencies of numerical responses in ratio estimation, Percept. Psychophys. 8, 358–362 (1970)

    Article  Google Scholar 

  108. H.R. Moskowitz: Magnitude estimation: Notes on what, how, when and why to use it, J. Food Quality 3, 195–227 (1977)

    Article  Google Scholar 

  109. H. Helson: Adaptation-Level Theory: An Experimental and Systematic Approach to Behavior (Harper and Row, New York 1964)

    Google Scholar 

  110. R.K. Eyman, P.J. Kim, T. Call: Judgment error in category versus magnitude scales, Percept. Mot. Skills 40, 415–423 (1975)

    Article  CAS  Google Scholar 

  111. A.L. Myers: Psychophysical scaling and scales of physical stimulus measurement, Psychol. Bull. 92, 203–214 (1982)

    Article  Google Scholar 

  112. F.N. Jones, M.J. Woskow: Some effects of context on the slope in magnitude estimation, J. Exp. Psychol. 71, 177–180 (1966)

    Article  CAS  Google Scholar 

  113. L.E. Marks, J.C. Stevens, L.M. Bartoshuk, J.F. Gent, B. Rifkin, V.K. Stone: Magnitude-matching: The measurement of taste and smell, Chem. Senses 13, 63–87 (1988)

    Article  Google Scholar 

  114. L.E. Marks, R. Szczesiul, P. Ohlott: On the cross-modal perception of intensity, J. Exp. Psychol.: Hum. Percept. Perform. 12, 517–534 (1986)

    CAS  Google Scholar 

  115. H. Eisler: How prothetic is the continuum of smell? A further comment on the relation between magnitude and category scales, Scand. J. Psychol. 10, 89–96 (1962)

    Google Scholar 

  116. R.L. Doty: On the protheticity of olfactory pleasantness and intensity, Percept. Mot. Skills 85, 1439–1449 (1997)

    Article  CAS  Google Scholar 

  117. J.E. Frijters: Three-stimulus procedures in olfactory psychophysics: An experimental comparison of Thurstone-Ura and three-alternative forced-choice models of signal detection theory, Percept. Psychophys. 28, 390–397 (1980)

    Article  CAS  Google Scholar 

  118. E.S. Choudhury, P. Moberg, R.L. Doty: Influences of age and sex on a microencapsulated odor memory test, Chem. Senses 28, 799–805 (2003)

    Article  Google Scholar 

  119. R. Weierstall, B.M. Pause: Development of a 15-item odour discrimination test (Dusseldorf Odour Discrimination Test), Perception 41, 193–203 (2012)

    Article  Google Scholar 

  120. S.S. Schiffman, M.L. Reynolds, F.W. Young: Introduction to Multidimensional Scaling: Theory, Methods, and Applications (Academic Press, Orlando 1981)

    Google Scholar 

  121. M. Carrasco, J.B. Ridout: Olfactory perception and olfactory imagery: A multidimensional analysis, J. Exp. Psychol.: Hum. Percept. Perform. 19, 287–301 (1993)

    CAS  Google Scholar 

  122. Y. Ueno: Perception of odor quality by Free Image-Association Test, Shinrigaku Kenkyu 63, 256–261 (1992)

    Article  CAS  Google Scholar 

  123. A. Abraham, K.V. Mathai: The effect of right temporal lobe lesions on matching of smells, Neuropsychologia 21, 277–281 (1983)

    Article  CAS  Google Scholar 

  124. D. Sumner: On testing the sense of smell, Lancet 2, 895–897 (1962)

    Article  CAS  Google Scholar 

  125. R.A. Gregson, D.A. Smith: The clinical assessment of olfaction: Differential diagnoses including Kallman’s syndrome, J. Psychosom. Res. 25, 165–174 (1981)

    Article  CAS  Google Scholar 

  126. W.S. Cain, J. Gent, F.A. Catalanotto, R.B. Goodspeed: Clinical evaluation of olfaction, Am. J. Otolaryngol. 4, 252–256 (1983)

    Article  CAS  Google Scholar 

  127. R.L. Doty, A. Marcus, W.W. Lee: Development of the 12-item cross-cultural smell identification test (CC-SIT), Laryngoscope 106, 353–356 (1996)

    Article  CAS  Google Scholar 

  128. A.H. Jackman, R.L. Doty: Utility of a three-item smell identification test in detecting olfactory dysfunction, Laryngoscope 115, 2209–2212 (2005)

    Article  Google Scholar 

  129. J.B. Wood, S.W. Harkins: Effects of age, stimulus selection, and retrieval environment on odor identification, J. Gerontol. 42, 584–588 (1987)

    Article  CAS  Google Scholar 

  130. H.N. Wright: Characterization of olfactory dysfunction, Arch. Otolaryngol. Head Neck Surg. 113, 163–168 (1987)

    Article  CAS  Google Scholar 

  131. W.S. Cain, R.D. Rabin: Comparability of two tests of olfactory function, Chem. Senses 14, 479–485 (1989)

    Article  Google Scholar 

  132. M. Larsson: Semantic factors in episodic recognition of common odors in early and late adulthood: A review, Chem. Senses 22, 623–633 (1997)

    Article  CAS  Google Scholar 

  133. Y. Yeshurun, Y. Dudai, N. Sobel: Working memory across nostrils, Behav. Neurosci. 122, 1031–1037 (2008)

    Article  Google Scholar 

  134. S.M. Bromley, R.L. Doty: Odor recognition memory is better under bilateral than unilateral test conditions, Cortex 31, 25–40 (1995)

    Article  CAS  Google Scholar 

  135. T. Engen, J.E. Kuisma, P.D. Eimas: Short-term memory of odors, J. Exp. Psychol. 99, 222–225 (1973)

    Article  CAS  Google Scholar 

  136. A.J. Johnson, C. Miles: Single-probe serial position recall: Evidence of modularity for olfactory, visual, and auditory short-term memory, Quart. J. Exp. Psychol. 62, 267–275 (2009)

    Article  Google Scholar 

  137. B.P. Jones, R.H. Moskowitz, N. Butters: Olfactory discrimination in alcoholic Korsakoff patients, Neuropsychol. 13, 173–179 (1975)

    Article  CAS  Google Scholar 

  138. S.J. Patel, A. Bollhoefer, R.L. Doty: Influences of ethanol ingestion on olfactory function in humans, Psychopharmacology 171, 4290434 (2004)

    Article  CAS  Google Scholar 

  139. M. Jones-Gotman, R.J. Zatorre: Odor recognition memory in humans: Role of right temporal and orbitofrontal regions, Brain Cogn. 22, 182–198 (1993)

    Article  CAS  Google Scholar 

  140. J.M. Campbell, R.A.M. Gregson: Olfactory short term memory in normal, schizophrenic and brain-damaged cases, Austral. J. Psychol. 24, 179–185 (1972)

    Article  Google Scholar 

  141. R.A. Gregson, M.L. Free, M.W. Abbott: Olfaction in Korsakoffs, alcoholics and normals, Br. J. Clin. Psychol. 20, 3–10 (1981)

    Article  CAS  Google Scholar 

  142. E.E. Morrison, R.M. Costanzo: Morphology of the human olfactory epithelium, J. Comp. Neurol. 297, 1–13 (1990)

    Article  CAS  Google Scholar 

  143. R. Naessen: An enquiry on the morphological characteristics and possible changes with age in the olfactory region of man, Acta Oto-Laryngol. 71, 49–62 (1971)

    Article  CAS  Google Scholar 

  144. T. Nakashima, C.P. Kimmelman, J.B. Snow Jr.: Structure of human fetal and adult olfactory neuroepithelium, Arch. Otolaryngol. 110, 641–646 (1984)

    Article  CAS  Google Scholar 

  145. S.I. Paik, M.N. Lehman, A.M. Seiden, H.J. Duncan, D.V. Smith: Human olfactory biopsy. The influence of age and receptor distribution, Arch. Otolaryngol. Head Neck Surg. 118, 731–738 (1992)

    Article  CAS  Google Scholar 

  146. L.J. Chapman, J.P. Chapman: Problems in the measurement of cognitive deficit, Psychol. Bull. 79, 380–385 (1973)

    Article  CAS  Google Scholar 

  147. T. Vollmecke, R.L. Doty: Development of the Picture Identification Test (PIT): A research companion to the University of Pennsylvania Smell Identification Test, Chem. Senses 10, 413–414 (1985)

    Google Scholar 

  148. R.L. Doty, M.B. Stern, C. Pfeiffer, S.M. Gollomp, H.I. Hurtig: Bilateral olfactory dysfunction in early stage treated and untreated idiopathic Parkinson’s disease, J. Neurol. Neurosurg. Psychiat. 55, 138–142 (1992)

    Article  CAS  Google Scholar 

  149. S.A. Betchen, R.L. Doty: Bilateral detection thresholds in dextrals and sinistrals reflect the more sensitive side of the nose, which is not lateralized, Chem. Senses 23, 453–457 (1998)

    Article  CAS  Google Scholar 

  150. V. Gudziol, C. Hummel, S. Negoias, T. Ishimaru, T. Hummel: Lateralized differences in olfactory function, Laryngoscope 117, 808–811 (2007)

    Article  Google Scholar 

  151. R.L. Doty, M. Kisat, I. Tourbier: Estrogen replacement therapy induces functional asymmetry on an odor memory/discrimination test, Brain Res. 1214, 35–39 (2008)

    Article  CAS  Google Scholar 

  152. T. Engen: Effect of practice and instruction on olfactory thresholds, Percept. Mot. Skills 10, 195–198 (1960)

    Article  Google Scholar 

  153. M.D. Rabin, W.S. Cain: Determinants of measured olfactory sensitivity, Percept. Psychophys. 39, 281–286 (1986)

    Article  CAS  Google Scholar 

  154. C.J. Wysocki, K.M. Dorries, G.K. Beauchamp: Ability to perceive androstenone can be acquired by ostensibly anosmic people, Proc. Nat. Acad. Sci. 86, 7976–7978 (1989)

    Article  CAS  Google Scholar 

  155. J.A. Desor, G.K. Beauchamp: The human capacity to transmit olfactory information, Percept. Psychophys. 16, 551–556 (1974)

    Article  Google Scholar 

  156. T. Engen, B.M. Ross: Long-term memory of odors with and without verbal descriptions, J. Exp. Psychol. 100, 221–227 (1973)

    Article  CAS  Google Scholar 

  157. W.S. Cain, F. Johnson Jr.: Lability of odor pleasantness: Influence of mere exposure, Percept. 7, 459–465 (1978)

    Article  CAS  Google Scholar 

  158. J.E. Cometto-Muñiz, W.S. Cain: Olfactory adaptation. In: Handbook of Olfaction and Gustation, ed. by R.L. Doty (Marcel Dekker, New York 1995) pp. 257–281

    Google Scholar 

  159. S.C. Karnekull, F.U. Jonsson, M. Larsson, J.K. Olofsson: Affected by smells? Environmental chemical responsivity predicts odor perception, Chem. Senses 36, 641–648 (2011)

    Article  Google Scholar 

  160. P. Dalton: Odor perception and beliefs about risk, Chem. Senses 21, 447–458 (1996)

    Article  CAS  Google Scholar 

  161. P. Dalton: Cognitive influences on health symptoms from acute chemical exposure, Health Psychol. 18, 579–590 (1999)

    Article  CAS  Google Scholar 

  162. G.M. Zucco, C. Militello, R.L. Doty: Discriminating between organic and psychological determinants of multiple chemical sensitivity: A case study, Neurocase 14, 485–493 (2008)

    Article  Google Scholar 

  163. S. Nordin, M. Martinkauppi, J. Olofsson, T. Hummel, E. Millqvist, M. Bende: Chemosensory perception and event-related potentials in self-reported chemical hypersensitivity, Int. J. Psychophysiol. 55, 243–255 (2005)

    Article  Google Scholar 

  164. T. Hummel, S. Roscher, M.P. Jaumann, G. Kobal: Intranasal chemoreception in patients with multiple chemical sensitivities: A double-blind investigation, Regul. Toxicol. Pharmacol. 24, S79–S86 (1996)

    Article  CAS  Google Scholar 

  165. E. Caccappolo, H. Kipen, K. Kelly-McNeil, S. Knasko, R.M. Hamer, B. Natelson, N. Fiedler: Odor perception: Multiple chemical sensitivities, chronic fatigue, and asthma, J. Occupat. Environ. Medi. 42, 629–638 (2000)

    Article  CAS  Google Scholar 

  166. R.L. Doty, B. Crastnopol: Correlates of chemosensory malingering, Laryngoscope 120, 707–711 (2010)

    Article  Google Scholar 

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Acknowledgements

The preparation of this chapter was supported, in part, by USAMRAA W81XWH-09-1-0467 from the Department of Defense.

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Doty, R.L. (2017). Psychophysical Testing of Human Olfactory Function. In: Buettner, A. (eds) Springer Handbook of Odor. Springer Handbooks. Springer, Cham. https://doi.org/10.1007/978-3-319-26932-0_23

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