Skip to main content

Long-Term Clinical Outcome Following CABG

  • Chapter
  • First Online:
Coronary Graft Failure

Abstract

Long-term results of aorto-coronary bypass surgery (CABG) are studied in numerous trials and meta-analyses, still presenting several, unresolved issues related to the type of graft (venous or arterial), cardiac performance, risk factors and other preexisting comorbidities (peripheral arteritis, carotid stenosis, renal and hepatic dysfunction, stroke, etc.). Noninvasive imaging techniques such as multislice computed tomography angiography (CTA) (64-128-256 row), CT64 coronary screening, magnetic resonance angiography (MRA), single photon emission tomography (SPET), and transthoracic and transesophageal Doppler echocardiography allow periodic evaluations of graft patency with similar results when compared with data obtained by coronary angiography. Arterial grafts, especially left internal mammary artery (LIMA), ensure longer permeability compared to the venous grafts. Given that interventional cardiology made great progress in complex lesion revascularization, surgical intervention is considered mainly in case of undilatable lesions, thus resolving the “stent or surgery” problem. It is, however, acknowledged that the permeability of bypass grafts is longer than that of conventional stents. Long-term monitoring of patients with coronary lesions treated surgically is difficult because these patients are usually older than 50 years and have associated diseases that can cause death unrelated to the permeability of grafts.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Buxton BF, Hayward PA, Newcomb AE, Moten S, Seevanayagam S, Gordon I. Choice of conduits for coronary artery bypass grafting: craft or science? Eur J Cardiothorac Surg. 2009;35:658–70.

    Article  PubMed  Google Scholar 

  2. The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Guidelines on myocardial revascularization. Eur J Cardiothorac Surg. 2010;38(S1):S1–52.

    Google Scholar 

  3. Achenbach S, Giesler T, Ropers D, Ulzheimer S, Derlien H, Schulte C, et al. Detection of coronary artery stenoses by contrast-enhanced, retrospectively electrocardiographically-gated, multislice spiral computed tomography. Circulation. 2001;103(21):2535–8.

    Article  CAS  PubMed  Google Scholar 

  4. Ehara M, Surmely JF, Kawai M, et al. Diagnostic accuracy of 64-slice computed tomography for detecting angiographically significant coronary artery stenosis in an unselected consecutive patient population: comparison with conventional invasive angiography. Circ J. 2006;70:564–71.

    Article  PubMed  Google Scholar 

  5. Nikolaou K, Knez A, Rist C, et al. Accuracy of 64-MDCT in the diagnosis of ischemic heart disease. AJR Am J Roentgenol. 2006;187:111–7.

    Article  PubMed  Google Scholar 

  6. Muhlenbruch G, Seyfarth T, Soo CS, Pregalathan N, Mahnken AH. Diagnostic value of 64-slice multi-detector row cardiac CTA in symptomatic patients. Eur Radiol. 2007;17(3):603–9.

    Article  PubMed  Google Scholar 

  7. van Domburg RT, Kappetein AP, Bogers AJ. The clinical outcome after coronary bypass surgery: a 30-year follow-up study. Eur Heart J. 2009;30(4):453–8.

    Article  PubMed  Google Scholar 

  8. Gramer BM, Diez Martinez P, Chin AS, Sylvestre M-P, Larrivée S, et al. 256-slice CT angiographic evaluation of coronary artery bypass grafts: effect of heart rate, heart rate variability and Z-axis location on image quality. PLoS One. 2014;9(3), e91861. doi:10.1371/journal.pone.0091861.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Exarhos DN, Baltouka A, Mihas C, Kouerinis I, Dedeilias P, Argiriou M, et al. Imaging and evaluation of coronary artery bypass graft patency by 16-slice multidetector computed tomography. Hellenic J Cardiol. 2007;48:258–67.

    PubMed  Google Scholar 

  10. Dirksen MS, Lamb HJ, Doornbos J, Bax JJ, Jukema JW, de Roos A. Coronary magnetic resonance angiography: technical developments and clinical applications. J Cardiovasc Magn Reson. 2003;5(2):365–86.

    Article  PubMed  Google Scholar 

  11. Goldman S, Zadina K, Moritz T, Ovitt T, Sethi G, Copeland JG, et al. Long-term patency of saphenous vein and left internal mammary artery grafts after coronary artery bypass surgery results from a Department of Veterans Affairs Cooperative Study. J Am Coll Cardiol. 2004;44:2149–56.

    Article  PubMed  Google Scholar 

  12. Weintraub WS, Clements Jr SD, Crisco LV, Guyton RA, Craver JM, Jones EL, et al. Twenty-year survival after coronary artery surgery: an institutional perspective from Emory University. Circulation. 2003;107:1271–7.

    Article  PubMed  Google Scholar 

  13. Taggart DP. Current status of arterial grafts for coronary artery bypass grafting. Ann Cardiothorac Surg. 2013;2(4):427–30.

    PubMed  PubMed Central  Google Scholar 

  14. Guo-Wei He. Arterial grafts for coronary bypass surgery. Berlin/Heidelberg: Springer; 2006. van Son JAM, Smedts FMM, Yang CQ, He GW. Cap 1 histology and comparison of arterial grafts used for coronary surgery. p. 19–32.

    Google Scholar 

  15. Lytle BW, Cosgrove DM, Saltus GL, Taylor PC, Loop FD. Multivessel coronary revascularization without saphenous vein: long-term results of bilateral internal mammary artery grafting. Ann Thorac Surg. 1983;36(5):540–7.

    Article  CAS  PubMed  Google Scholar 

  16. Loop FD, Lytle BW, Cosgrove DM, et al. Influence of the internal-mammary-artery graft on 10-year survival and other cardiac events. N Engl J Med. 1986;314:1–6.

    Article  CAS  PubMed  Google Scholar 

  17. Kolessov VI. Mammary artery-coronary artery anastomosis as method of treatment for angina pectoris. J Thorac Cardiovasc Surg. 1967;54(4):535–44.

    CAS  PubMed  Google Scholar 

  18. Shrager JB. The Vineberg procedure: the immediate forerunner of coronary artery bypass grafting. Ann Thorac Surg. 1994;57:1354–6.

    Article  CAS  PubMed  Google Scholar 

  19. Ochsner JL, Lawson JD, Eskind SJ, Mills NL, DeCamp PT. Homologous veins as an arterial substitute, long term results. J Vasc Surg. 1987;1:306–13.

    Article  Google Scholar 

  20. Tatoulis J. Total arterial coronary revascularization—patient selection, stenoses, conduits, targets. Ann Cardiothorac Surg. 2013;2(4):499–506.

    PubMed  PubMed Central  Google Scholar 

  21. Tabata M, Grab JD, Khalpey Z, Edwards FH, O’Brien SM, Cohn LH, et al. Prevalence and variability of internal mammary artery graft use in contemporary multivessel coronary artery bypass graft surgery: analysis of the Society of Thoracic Surgeons National Cardiac Database. Circulation. 2009;120(11):935–40.

    Article  PubMed  Google Scholar 

  22. Shahian DM, O’Brien SM, Sheng S, Grover FL, Mayer JE, Jacobs JP, et al. Predictors of long-term survival after coronary artery bypass grafting surgery: results from the Society of Thoracic Surgeons Adult Cardiac Surgery Database (the ASCERT study). Circulation. 2012;125:1491–500.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Buxton BF, Hayward PA. The art of arterial revascularization—total arterial revascularization in patients with triple vessel coronary artery disease. Ann Cardiothorac Surg. 2013;2(4):543–51.

    PubMed  PubMed Central  Google Scholar 

  24. Lytle BW, Blackstone E, Loop FD, Houghtaling PL, Arnold J, Akhrass R, et al. Two internal thoracic artery grafts are better than one. J Thorac Cardiovasc Surg. 1999;117:855–72.

    Article  CAS  PubMed  Google Scholar 

  25. Tector AJ, Kress DC, Downey FX, Schmahl TM. Complete revascularisation with internal thoracic artery grafts. Semin Thorac Cardiovasc Surg. 1996;8(1):29–46.

    CAS  PubMed  Google Scholar 

  26. Smith T, Kloppenburg GTL, Morshuis WJ. Does the use of bilateral mammary artery grafts compared with the use of a single mammary artery graft offer a long-term survival benefit in patients undergoing coronary artery bypass surgery? Interact Cardiovasc Thorac Surg. 2014;1:96–102.

    Article  Google Scholar 

  27. Kurlanskya PA, Traada EA, Dormanb MJ, Galbuta DL, Zuckera M, Ebra G. Bilateral internal mammary artery grafting reverses the negative influence of gender on outcomes of coronary artery bypass grafting surgery. Eur J Cardiothorac Surg. 2013;44:54–63.

    Article  Google Scholar 

  28. Mediratta N, Chalmers J, Pullan M, McShane J, Shaw M, Poullis M. In-hospital mortality and long-term survival after coronary artery bypass surgery in young patients. Eur J Cardiothorac Surg. 2013;43:1014–21.

    Article  PubMed  Google Scholar 

  29. David Hillis L, Smith PK, Anderson JL, Bittl JA, Bridges CR, Byrne JG, et al. 2011 ACCF/AHA guideline for coronary artery bypass graft surgery. J Am Coll Cardiol. 2011;58(24):e123–210. doi:10.1016/j.jacc.2011.08.009.

    Article  PubMed  Google Scholar 

  30. FitzGibbon GM, Leach AJ, Kafka HP, Keon WJ. Coronary bypass graft fate: long-term angiographic study. J Am Coll Cardiol. 1991;17:1075–80.

    Article  CAS  PubMed  Google Scholar 

  31. Maddock S, Tang GHL, Aronow WS, Malekan R. Cap 7. Total arterial revascularization in coronary artery bypass grafting surgery. In: Aronow WS, editor. Artery bypass. Rijeka: InTech; 2013.

    Google Scholar 

  32. Achouha P, Isselmoua KO, Boutekadjirtb R, D’Alessandrob C, Achouha P, Pagny JY, et al. Reappraisal of a 20-year experience with the radial artery as a conduit for coronary bypass grafting. Eur J Cardiothorac Surg. 2012;41:87–92.

    Article  Google Scholar 

  33. Cheng Z, Zhao Z, Quan X, Wang S, Zhao J, Sun J, et al. Twelve years’ experience and clinical results of using the radial artery for coronary revascularization. Chin Med J. 2014;127(5):887–92.

    PubMed  Google Scholar 

  34. Possati G, Gaudino M, Prati F, Alessandrini F, Trani C, Glieca F, et al. Long-term results of the radial artery used for myocardial revascularization. Circulation. 2003;108:1350–4.

    Article  PubMed  Google Scholar 

  35. Georghiou GP, Vidne BA, Dunning J. Does the radial artery provide better long-term patency than the saphenous vein? Interact Cardiovasc Thorac Surg. 2005;4:304–10.

    Article  PubMed  Google Scholar 

  36. Nezic DG, Knezevic AM, Milojevic PS, Pukanovic B, Jovic M, Borzanovic MD, et al. The fate of the radial artery conduit in coronary artery bypass grafting surgery. Eur J Cardiothorac Surg. 2006;30:341–6.

    Article  PubMed  Google Scholar 

  37. Blitz A, Osterday RM, Brodman RF. Harvesting the radial artery. Ann Cardiothorac Surg. 2013;2(4):533–42.

    PubMed  PubMed Central  Google Scholar 

  38. Lima LM, Galvina SD, Javidb M, Matalanisa G. Should the radial artery be used as a bypass graft following radial access coronary angiography. Interact Cardiovasc Thorac Surg. 2014;18:219–24.

    Article  Google Scholar 

  39. Watson RA, Hamza M, Tsakokc TM, Tsakok MT. Radial artery for coronary artery bypass grafting: does proximal anastomosis to the aorta or left internal mammary artery achieve better patency? Interact Cardiovasc Thorac Surg. 2013;17:1020–4.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Schwann TA, Zacharias A, Riordan CJ, Durham SJ, Shah AS, Habib RH. Does radial use as a second arterial conduit for coronary artery bypass grafting improve long-term outcomes in diabetics? Eur J Cardiothorac Surg. 2008;33:914–23.

    Article  PubMed  Google Scholar 

  41. Suma H, Amano A, Horii T, Kigawa I, Fukuda S, Wanibuchi Y. Gastroepiploic artery graft in 400 patients. Eur J Cardiothorac Surg. 1996;10:6–11.

    Article  CAS  PubMed  Google Scholar 

  42. Pietro Giorgio Malvindia, Samuel Jacob, Antonios Kallikourdis, Nicola Vitale. What is the patency of the gastroepiploic artery when used for coronary artery bypass grafting? Interactive Cardiovasc Thorac Surg. 2007;6:397–402.

    Google Scholar 

  43. Glineur D, D’hoore W, Price J, Dorméus S, de Kerchove L, Dion R, et al. Survival benefit of multiple arterial grafting in a 25-year single institutional experience: the importance of the third arterial graft. Eur J Cardiothorac Surg. 2012;42:284–91.

    Article  PubMed  Google Scholar 

  44. Suzuki T, Asai T, Matsubayashi K, Kambara A, Kinoshita T, Takashima N, et al. In off-pump surgery, skeletonized gastroepiploic artery is superior to saphenous vein in patients with bilateral internal thoracic arterial grafts. Ann Thorac Surg. 2011;91:1159–64.

    Article  PubMed  Google Scholar 

  45. Esaki J, Koshiji T, Okamoto M, Tsukashita M, Ikuno T, Sakata R. Gastroepiploic artery grafting does not improve the late outcome in patients with bilateral internal thoracic artery grafting. Ann Thorac Surg. 2007;83:1024–9.

    Article  PubMed  Google Scholar 

  46. Chaudhry UA, Rao C, Harling L, Athanasiou T. Does off-pump coronary artery bypass graft surgery have a beneficial effect on long-term mortality and morbidity compared with on-pump coronary artery bypass graft surgery? Interact Cardiovasc Thorac Surg. 2014;19:149–59.

    Article  PubMed  Google Scholar 

  47. Abu-Omar Y, Taggart DP. The present status of off-pump coronary artery bypass grafting. Eur J Cardiothorac Surg. 2009;36:312–21.

    Article  PubMed  Google Scholar 

  48. Pottmeyer EW, Stillman PC. Off-pump coronary artery bypass surgery. Hosp Physician. 2000;64–69.

    Google Scholar 

  49. Ramadan AS, Stefanidis C, N’Gatchou W, El Oumeiri B, Jansens JL, De Smet JM, et al. Five years follow-up after Y-graft arterial revascularization: on pump versus off pump; prospective clinical trial. Interact Cardiovasc Thorac Surg. 2010;10:423–7.

    Article  PubMed  Google Scholar 

  50. Khan NE, De Souza A, Mister R, et al. A randomized comparison of off-pump and on-pump multivessel coronary-artery bypass surgery. N Engl J Med. 2004;350:21–8.

    Article  CAS  PubMed  Google Scholar 

  51. Loulmet D, Carpentier A, d’Attellis N, Berrebi A, Cardon C, Ponzio O, et al. Endoscopic coronary artery bypass grafting with the aid of robotic assisted instruments. J Thorac Cardiovasc Surg. 1999;118:4–10.

    Article  CAS  PubMed  Google Scholar 

  52. de Canniere D, Wimmer-Greinecker G, Cichon R, Gulielmos V, Van Praet F, Seshadri-Kreaden U, et al. Feasibility, safety, and efficacy of totally endoscopic coronary artery bypass grafting: multicenter European experience. J Thorac Cardiovasc Surg. 2007;134:710–6.

    Article  PubMed  Google Scholar 

  53. Farhat F, Aubert S, Blanc P, Jegaden O. Totally endoscopic off-pump bilateral internal thoracic artery bypass grafting. Eur J Cardiothorac Surg. 2004;26:845–7.

    Article  PubMed  Google Scholar 

  54. Bonatti J, Schachner T, Bonaros N, Ohlinger A, Danzmayr M, Jonetzko P, et al. Technical challenges in totally endoscopic robotic coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2006;131:146–53.

    Article  CAS  PubMed  Google Scholar 

  55. Wiedemann D, Schachner T, Bonaros N, Weidinger F, Kolbitsch C, Friedrich G, et al. Does obesity affect operative times and perioperative outcome of patients undergoing totally endoscopic coronary artery bypass surgery? Interact Cardiovasc Thorac Surg. 2009;9(2):214–7.

    Article  PubMed  Google Scholar 

  56. van Straten AH, Soliman Hamad MA, van Zundert AA, Martens EJ, Schönberger JP, ter Woorst JF, et al. Diabetes and survival after coronary artery bypass grafting: comparison with an age- and sex-matched population. Eur J Cardiothorac Surg. 2010;37:1068–74.

    Article  PubMed  Google Scholar 

  57. Antunes PE, de Oliveira JF, Antunes MJ. Coronary surgery in patients with diabetes mellitus: a risk-adjusted study on early outcome. Eur J Cardiothorac Surg. 2008;34:370–5.

    Article  PubMed  Google Scholar 

  58. Grossi EA, Esposito R, Harris LJ, Crooke GA, Galloway AC, Colvin SB, et al. Sternal wound infection and use of internal mammary artery grafts. J Thorac Cardiovasc Surg. 1991;102:342–7.

    CAS  PubMed  Google Scholar 

  59. Borger MA, Rao V, Weisel RD, Ivanov J, Cohen G, Scully HE, et al. Seep sternal wound infection: risk factor and outcomes. Ann Thorac Surg. 1998;65:1050–6.

    Article  CAS  PubMed  Google Scholar 

  60. Hirose H, Amano A, Takanashi S, Takahashi A. Skeletonized bilateral internal mammary artery grafting for patients with diabetes. Interact Cardiovasc Thorac Surg. 2003;2:287–92.

    Article  PubMed  Google Scholar 

  61. Stevens LM, Carrier M, Perrault LP, Hebert Y, Cartier R, Bouchard D, et al. Influence of diabetes and bilateral internal thoracic artery grafts on long-term outcome for multivessel coronary artery bypass grafting. Eur J Cardiothorac Surg. 2005;27:281–8.

    Article  CAS  PubMed  Google Scholar 

  62. Kappetein AP, Head SJ, Morice MC, Banning AP, Serruys PW, Mohr FW, et al. Treatment of complex coronary artery disease in patients with diabetes: 5-year results comparing outcomes of bypass surgery and percutaneous coronary intervention in the SYNTAX trial. Eur J Cardiothorac Surg. 2013;43:1006–13.

    Article  PubMed  Google Scholar 

  63. 2014 ESC/EACTS Guidelines on myocardial revascularization. The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur J Cardiothorac Surg. 0(2014): 1–101.

    Google Scholar 

  64. Saxena A, Dinh D, Smith JA, Shardey G, Reid CM, Newcomb AE. Sex differences in outcomes following isolated coronary artery bypass graft surgery in Australian patients: analysis of the Australasian Society of Cardiac and Thoracic Surgeons cardiac surgery database. Eur J Cardiothorac Surg. 2012;41:755–62.

    Article  PubMed  Google Scholar 

  65. Blasberg JD, Schwartz GS, Balaram SK. The role of gender in coronary surgery. Eur J Cardiothorac Surg. 2011;40:715–21.

    PubMed  Google Scholar 

  66. Pullan M, Kirmani BH, Conley T, Oo A, Shaw M, McShane J, et al. The effect of patient sex on survival in patients undergoing isolated coronary artery bypass surgery receiving a radial artery. Eur J Cardiothorac Surg. 2015;47:324–30.

    Article  PubMed  Google Scholar 

  67. Sen B, Niemann B, Roth P, Aser R, Schönburg M, Böning A. Short- and long-term outcomes in octogenarians after coronary artery bypass surgery. Eur J Cardiothorac Surg. 2012;42:102–7.

    Article  Google Scholar 

  68. Muneretto C, Negri A, Bisleri G, Manfredi J, Terrini A, Metra M, et al. Is total arterial myocardial revascularization with composite grafts a safe and useful procedure in the elderly? Eur J Cardiothorac Surg. 2003;23:657–64.

    Article  PubMed  Google Scholar 

  69. Yanagawa B, Algarni KD, Yau TM, Rao V, Brister SJ. Improving results for coronary artery bypass graft surgery in the elderly. Eur J Cardiothorac Surg. 2012;42:507–12.

    Article  PubMed  Google Scholar 

  70. Pettinari M, Sergeant P, Meuris B. Bilateral internal thoracic artery grafting increases long-term survival in elderly patients. Eur J Cardiothorac Surg. 2014;1–7.

    Google Scholar 

  71. Wong D, Thompson G, Buth K, Sullivan J, Ali I. Angiographic coronary diffuseness and outcomes in dialysis patients undergoing coronary artery bypass grafting surgery. Eur J Cardiothorac Surg. 2003;24:388–92.

    Article  PubMed  Google Scholar 

  72. Charytan DM, Yang SS, McGurk S, Rawn J. Long- and short-term outcomes following coronary artery bypass grafting in patients with and without chronic kidney disease. Nephrol Dial Transplant. 2010;25:3663–72.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Marian Gaspar MD, PhD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Gaspar, M., Călinescu, F.B. (2016). Long-Term Clinical Outcome Following CABG. In: Ţintoiu, I., Underwood, M., Cook, S., Kitabata, H., Abbas, A. (eds) Coronary Graft Failure. Springer, Cham. https://doi.org/10.1007/978-3-319-26515-5_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-26515-5_20

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-26513-1

  • Online ISBN: 978-3-319-26515-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics