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Pleiotropic mechanisms of ribavirin antiviral activities

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Progress in Drug Research

Part of the book series: Progress in Drug Research ((PDR,volume 59))

Summary

Renewed interest in the mechanism of action of ribavirin results from its synergistic enhancement of interferon therapy and the need to develop more efficacious agents to treat hepatitis C virus infection. Since the discovery of ribavirin over 30 years ago by scientists at ICN Pharmaceuticals, many mechanisms of action for ribavirin have been proposed. These include inhibition of host inosine monophosphate dehydrogenase by ribavirin monophosphate, inhibition of viral capping enzymes, inhibition of viral RNA synthesis by ribavirin triphosphate, lethal mutagenesis of viral RNA genomes resulting from promiscuous incorporation of ribavirin triphosphate by the viral RNA polymerase, and modulation of the host immune responses. In this article, we will briefly review the evidence for these mechanisms, emphasizing recent findings. In addition, we will discuss strategies for development of nucleoside analogs that may replace ribavirin in the future.

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Authors and Affiliations

  1. Drug Discovery, ICN Pharmaceuticals, Inc., 3300 Hyland Avenue, Costa Mesa, CA, 92626, USA

    Zhi Hong

  2. Department of Biochemistry & Molecular Biology, Pennsylvania State University, 201 Althouse Lab, University Park, PA, 16802-4500, USA

    Craig E. Cameron

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  1. Zhi Hong
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  2. Craig E. Cameron
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  1. Steinweg 28, Ettingen, CH-4107, Switzerland

    Ernst Jucker

  2. Basel, Switzerland

    Ernst Jucker

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Hong, Z., Cameron, C.E. (2002). Pleiotropic mechanisms of ribavirin antiviral activities. In: Jucker, E. (eds) Progress in Drug Research. Progress in Drug Research, vol 59. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8171-5_2

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  • DOI: https://doi.org/10.1007/978-3-0348-8171-5_2

  • Publisher Name: Birkhäuser, Basel

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