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Biomarkers of Myocardial Necrosis

Past, Present, and Future

  • Chapter
Cardiovascular Biomarkers

Part of the book series: Contemporary Cardiology ((CONCARD))

Abstract

Biochemical markers play a crucial role in accurate diagnosis of myocardial necrosis and, more importantly, for assessing risk and directing appropriate therapy that improves clinical outcome. Development and utilization of biomarkers has evolved substantially over the past three decades. The earliest biomarkers, such as alanine aminotransferase and lactate dehydrogenase, have fallen out of use with the development of moer sensitive and specific assays for creatine kinase isoenzyme MB and particularly cardiac troponin. Cardiac troponin T or I measurements are now considered surrogates for necrosis and myocardial infarction when elevated in the setting of acute cardiac ischemia. This chapter offers insight into evolution of cardiac biomarkers and offers thoughts regarding the future of necrosis biomarkers.

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Authors and Affiliations

  1. Departments of Pathology and Medical & Research Technology, University of Maryland School of Medicine, Baltimore, MD

    Robert H. Christenson PhD (Professor of Pathology and Professor of Medical and Research Technology)

  2. Department of Chemistry, School of Sciences and Engineering, The American University In Cairo, Cairo, Egypt

    Hassan M. E. Azzazy PhD, DABCC (Associate Professor)

Authors
  1. Robert H. Christenson PhD
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  2. Hassan M. E. Azzazy PhD, DABCC
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Editors and Affiliations

  1. Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

    David A. Morrow MD, MPH

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Christenson, R.H., Azzazy, H.M.E. (2006). Biomarkers of Myocardial Necrosis. In: Morrow, D.A. (eds) Cardiovascular Biomarkers. Contemporary Cardiology. Humana Press. https://doi.org/10.1007/978-1-59745-051-5_1

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  • DOI: https://doi.org/10.1007/978-1-59745-051-5_1

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