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Attention-Deficit/Hyperactivity Disorder: Focus upon Aberrant N-Methyl-d-Aspartate Receptors Systems

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Neurotoxin Modeling of Brain Disorders—Life-long Outcomes in Behavioral Teratology

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 29))

Abstract

Attention-deficit/hyperactivity disorder (ADHD) pathophysiology persists in an obscure manner with complex interactions between symptoms, staging, interventions, genes, and environments. Only on the basis of increasing incidence of the disorder, the need for understanding is greater than ever. The notion of an imbalance between central inhibitory/excitatory neurotransmitters is considered to exert an essential role. In this chapter, we first review how the default mode network functions and dysfunction in individuals diagnosed with ADHD. We also present and briefly review some of the animal models used to examine the neurobiological aspects of ADHD. There is much evidence indicating that compounds/interventions that antagonize/block glutamic acid receptors and/or block the glutamate signal during the “brain growth spurt” or in the adult animal may induce functional and biomarker deficits. Additionally, we present evidence suggesting that animals treated with glutamate blockers at the period of the “brain growth spurt” fail to perform the exploratory activity, observed invariably with control mice, that is associated with introduction to a novel environment (the test cages). Later, when the control animals show less locomotor and rearing activity, i.e., interest in the test cages, the MK-801, ketamine and ethanol treated mice showed successively greater levels of locomotion and rearing (interest), i.e., they fail to “habituate” effectively, implying a cognitive dysfunction. These disturbances of glutamate signaling during a critical period of brain development may contribute to the ADHD pathophysiology. As a final addition, we have briefly identified new research venues in the interaction between ADHD, molecular studies, and personality research.

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Notes

  1. 1.

    A network of brain regions that are active when the individual is not focused on the outside world and the brain is at wakeful rest.

  2. 2.

    The Wistar rat is an outbred albino rat.

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Authors and Affiliations

  1. Department of Psychology, University of Gothenburg, Box 500, SE 40530, Gothenburg, Sweden

    Trevor Archer & Danilo Garcia

  2. Network for Empowerment and Well-Being, University of Gothenburg, Gothenburg, Sweden

    Trevor Archer & Danilo Garcia

  3. Blekinge Center of Competence, Blekinge County Council, Karlskrona, Sweden

    Danilo Garcia

  4. Centre for Ethics, Law and Mental Health (CELAM), University of Gothenburg, Gothenburg, Sweden

    Danilo Garcia

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  1. Department of Biomedical Sciences, East Tennessee State University, Johnson City, TN, USA

    Richard M. Kostrzewa

  2. Department of Psychology, University of Gothenburg, Gothenburg, Sweden

    Trevor Archer

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Archer, T., Garcia, D. (2015). Attention-Deficit/Hyperactivity Disorder: Focus upon Aberrant N-Methyl-d-Aspartate Receptors Systems. In: Kostrzewa, R.M., Archer, T. (eds) Neurotoxin Modeling of Brain Disorders—Life-long Outcomes in Behavioral Teratology. Current Topics in Behavioral Neurosciences, vol 29. Springer, Cham. https://doi.org/10.1007/7854_2015_415

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