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The Vascular Endothelium II pp 79–95Cite as

Biomechanical Modulation of Endothelial Phenotype: Implications for Health and Disease

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 176/II))

Abstract

The functional phenotypic plasticity of the vascular endothelium relies on the ability of individual endothelial cells to integrate and transduce both humoral and biomechanical stimuli from their surrounding environments. Increasing evidence strongly suggests that biomechanical stimulation is a critical determinant of endothelial gene expression and the functional phenotypes displayed by these cells in several pathophysiological conditions. Herein we discuss the types of biomechanical forces that endothelial cells are constantly exposed to within the vasculature, explain how these biomechanical stimuli serve as regulators of endothelial functionanddiscuss the increasing evidence that “atherosclerosis-protective” or “atherosclerosis-prone” haemodynamic environments can beimportant causative factors for atherogenesis via the differential regulation of endothelial transcriptional programmes.

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Authors and Affiliations

  1. Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, NRB-7, 02115, MA, Boston, USA

    G. García-Cardeña & M. A. Gimbrone Jr.

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  1. G. García-Cardeña
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  2. M. A. Gimbrone Jr.
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Editors and Affiliations

  1. The Wolfson Institute for Biomedical Research, University College London, Gower Street, London, WC1E 6BT, UK

    Salvador Moncada FRCP FRS  & Annie Higgs  & 

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García-Cardeña, G., Gimbrone, M.A. (2006). Biomechanical Modulation of Endothelial Phenotype: Implications for Health and Disease. In: Moncada, S., Higgs, A. (eds) The Vascular Endothelium II. Handbook of Experimental Pharmacology, vol 176/II. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-36028-X_3

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