Abstract
Research conducted in laboratory animals has shown adolescents to be less sensitive to numerous ethanol effects that may serve as cues to limit intake, including effects evident during intoxication (e.g., ethanol-induced motor impairment, anxiolysis, social impairment, and sedation), as well as during the post-intoxication period (e.g., "hangover"-associated anxiogenesis). Conversely, adolescents are more sensitive than adults to a few ethanol effects, including ethanol-induced social facilitation and impairments in hippocampal long-term-potentiation. These age-specific ethanol sensitivities are not simply related to developmental differences in ethanol pharmacokinetics. Instead, they appear related in part to an ontogenetic decline in expression of within session (acute) tolerance and to differential rates of development of neural systems underlying different actions of ethanol. Relatively high levels of ethanol intake often seen in adolescent rodents and their human counterparts may be related not only to an attenuated sensitivity of adolescents to negative cues that normally serve to limit drinking, but also their greater sensitivity to both the facilitation of social behavior by ethanol and the stimulation of ethanol intake by social experiences. Although data are sparse, studies in laboratory animals hint that under some circumstances chronic adolescent exposure to ethanol may influence ongoing neural maturation and later neural, cognitive, and behavioral functioning, including later sensitivity to and propensity to use ethanol. Recommendations for further research are discussed.
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References
Acheson SK, Richardson R, Swartzwelder HS: Developmental changes in seizure susceptibility during ethanol withdrawal. Alcohol 18:23–26, 1999.
Acheson SK, Stein RM, Swartzwelder HS: Impairment of semantic and figural memory by acute ethanol: Age-dependent effects. Alcohol Clin Exp Res 22:1437–1442, 1998.
Adams, J., Barone, S., Jr., LaMantia, A. et al. Workshop to identify critical windows of exposure for children's health: Neurobehavioral work group summary. Environm. Health Perspect. 108:535–544, 2000.
Alkana RL, Davies DL, Lê AD: Ethanol's acute effects on thermoregulation: Mechanisms and consequences, in Deitrich RA and Erwin VG (eds): Pharmacological Effects of Ethanol on the Nervous System. Boca Raton, CRC Press, 1996, pp 291–328.
Beck KH, Thombs DL, Summons TG: The social context of drinking scales: Construct validation and relationship to indicants of abuse in an adolescent population. Addict Behav 18:159–169, 1993.
Beck KH, Treiman KA: The relationship of social context of drinking, perceived social norms, and parental influence to various drinking patterns of adolescents. Addict Behav 21:633–644, 1996.
Benson RM, Migeon CJ: Physiological and pathological puberty, and human behavior, in Eleftheriou BE and Sprott RL (eds): Hormonal Correlates of Behavior: A Lifespan View, Vol. 1. New York, Plenum Press, 1975, pp 155–184.
Brasser SM, Spear NE: Physiological and behavioral effects of acute ethanol hangover in juvenile, adolescent, and adult rats. Behav Neurosci 116:305–320, 2002.
Brunell SC, Rajendran P, Spear LP: Ethanol intake and stress adaptation in adolescent and adult rats. Presented at the annual meeting of the Society for Neuroscience, November, 2001, San Diego, CA.
Campanelli C, Lê AD, Khanna JM, et al: Effect of raphe lesions on the development of acute tolerance to ethanol and pentobarbital. Psychopharmacology (Berl) 96:454–457, 1988.
Chotro MG, Molina JC: Acute ethanol contamination of the amniotic fluid during gestational day 21: Postnatal changes in alcohol responsiveness in rats. Dev Psychobiol 23:535–547, 1990.
Chugani HT: Neuroimaging of developmental nonlinearity and developmental pathologies, in Thatcher RW, Lyon GR, Rumsey J, Krasnegor N (eds): Developmental Neuroimaging: Mapping the Development of Brain and Behavior. San Diego, Academic Press, 1996, pp 187–195.
Cicero TJ, Adams ML, O'Connor L, et al: Influence of chronic alcohol administration on representative indices of puberty and sexual maturation in male rats and the development of their progeny. J Pharmacol Exp Ther 255:707–715, 1990.
Crews FT, Braun CJ, Hoplight B, et al: Binge ethanol consumption causes differential brain damage in young adolescent rats compared with adult rats. Alcohol Clin Exp Res 24:1712–1723, 2000.
Doremus TL, Brunell SC, Pottayil R, et al: Elevated ethanol consumption in adolescent relative to adult rats. Presented at the annual meeting of the Research Society on Alcoholism, June, 2003a, Fort Lauderdale, FL.
Doremus TL, Brunell SC, Varlinskaya EI, et al: Anxiogenic effects during withdrawal from acute ethanol in adolescent and adult rats. Pharmacol Biochem Behav 75:411–418, 2003b.
Eckardt MJ, File SE, Gessa GL, et al: Effects of moderate alcohol consumption on the central nervous system. Alcohol Clin Exp Res 22:998–1040, 1998.
Ernst AJ, Dempster JP, Yee R, et al: Alcohol toxicity, blood alcohol concentration and body water in young and adult rats. J Stud Alcohol 37:347–356, 1976.
Fernández-Vidal JM, Spear NE, Molina JC: Adolescent rats discriminate a mild state of ethanol intoxication likely to act as an appetitive unconditioned stimulus. Alcohol 30:45–60, 2003.
Ferris CF, Shtiegman K, King JA: Voluntary ethanol consumption in male adolescent hamsters increases testosterone and aggression. Physiol Behav 63:739–744, 1998.
Galef BG Jr, Kennett DJ, Stein M: Demonstrator influence on observer diet preference: Effects of simple exposure and the presence of a demonstrator. Anim Learn Behav 13:25–30, 1985.
Grieve SJ, Littleton JM: Age and strain differences in the rate of development of functional tolerance to ethanol by mice. J Pharm Pharmacol 31:696–700, 1979.
Grobin AC, Matthews DB, Montoya D, et al: Age-related differences in neurosteroid potentiation of muscimol-stimulated 36CI− flux following chronic ethanol treatment. Neuroscience 105:547–552, 2001.
Hernandez M, Spear LP: Ethanol-induced analgesia in adolescent and adult rats. Presented at the annual meeting of the International Society for Developmental Psychobiology, November, 2003, New Orleans, LA.
Ho A, Chin AJ, Dole VP: Early experience and the consumption of alcohol by adult C57BL/6J mice. Alcohol 6:511–515, 1989.
Hollstedt C, Olsson O, Rydberg U: The effect of alcohol on the developing organism: Genetical, teratological and physiological aspects. Med Biol 55:1–14, 1977.
Hollstedt C, Olsson O, Rydberg U: Effects of ethanol on the developing rat. II. Coordination as measured by the tilting-plane test. Med Biol 58:164–168, 1980.
Hollstedt C, Rydberg U: Alcohol and the developing organism: experimental and clinical aspects, in Ideström C-M (ed): Recent Advances in the Study of Alcoholism (Proceedings of the First International Magnus Huss Symposium, Stockholm, 2–3 September 1976). Amsterdam-Oxford, Excerpta Medica, 1977, pp. 93–100.
Honey PL, Galef BG Jr: Ethanol consumption by rat dams during gestation, lactation and weanling increases ethanol consumption by their adolescent young. Dev Psychobiol 42:252–260, 2003.
Hunt PS, Holloway JL, Scordalakes EM: Social interaction with an intoxicated sibling can result in increased intake of ethanol by periadolescent rats. Dev Psychobiol 38:101–109, 2001.
Hunt PS, Lant GM, Carroll CA: Enhanced intake of ethanol in preweanling rats following interactions with intoxicated siblings. Dev Psychobiol 37:90–99, 2000.
Hunt PS, Molina JC, Rajachandran L, et al: Chronic administration of alcohol in the developing rat: Expression of functional tolerance and alcohol olfactory aversions. Behav Neural Biol 59:87–99, 1993.
Johnston LD, O'Malley PM, Bachman JG: The Monitoring the Future National Survey Results on Adolescent Drug Use: Overview of Key Findings, 2000 (NIH Publication No. 01-4923). Bethesda, National Institute on Drug Abuse, 2001, pp 1–60.
Kakihana R, McClearn GE: Development of alcohol preference in BALB/c mice. Nature 199:511–512, 1963.
Kalant H: Problems in the search for mechanisms of tolerance. Alcohol Alcohol Suppl 2:1–8, 1993.
Keir WJ, Deitrich RA: Development of central nervous system sensitivity to ethanol and pentobarbital in short-and long-sleep mice. J Pharmacol Exp Ther 254:831–835, 1990.
Kelly SJ, Bonthius DJ, West JR: Developmental changes in alcohol pharmacokinetics in rats. Alcohol Clin Exp Res 11:281–286, 1987.
Khanna JM, Campanelli C, Lê AD, et al: Effect of raphe lesions on the development of chronic tolerance to pentobarbital and cross-tolerance to ethanol. Psychopharmacology (Berl) 91:473–478, 1987.
Lad PJ, Schenk DB, Leffert HL: Inhibitory monoclonal antibodies against rat liver alcohol dehydrogenase. Arch Biochem Biophys 235:589–595, 1984.
Lagerspetz, KYH: Postnatal development of the effects of alcohol and of the induced tolerance to alcohol in mice. Acta Pharmacol et Toxicol 31:497–508, 1972.
Lancaster FE, Brown TD, Coker KL, et al: Sex differences in alcohol preference and drinking patterns emerge during the early postpubertal period in Sprague-Dawley rats. Alcohol Clin Exp Res 20:1043–1049, 1996.
Lee MH, Heaney A, Rabe A: Repeated binge exposure to alcohol of periadolescent rats produces lasting functional changes. Abstr Soc Neurosci 27:877.14, November, 2001, San Diego, CA.
Li Q, Wilson WA, Swartzwelder HS: Differential effect of ethanol on NMDA EPSCs in pyramidal cells in the posterior cingulate cortex of juvenile and adult rats. J Neurophysiol 87:705–711, 2002.
Little PJ, Adams ML, Cicero TJ: Effects of alcohol on the hypothalamic-pituitary-gonadal axis in the developing male rat. J Pharmacol Exp Ther 263:1056–1061, 1992.
Little PJ, Kuhn CM, Wilson WA, et al: Differential effects of ethanol in adolescent and adult rats. Alcohol Clin Exp Res 20:1346–1351, 1996.
Markwiese BJ, Acheson SK, Levin ED, et al: Differential effects of ethanol on memory in adolescent and adult rats. Alcohol Clin Exp Res 22:416–421, 1998.
Martin CS, Winters KC: Diagnosis and assessment of alcohol use disorders among adolescents. Alcohol Res Health 22:95–105, 1998.
McDonald JW, Johnston MV: Physiological and pathophysiological roles of excitatory amino acids during central nervous system development. Brain Res Brain Res Rev 15:41–70, 1990.
Molina JC, Chotro G, Spear NE: Early (preweanling) recognition of alcohol's orosensory cues resulting from acute ethanol intoxication. Behav Neural Biol 51:307–325, 1989.
Morzorati SL, Ramchandani VA, Flury L, et al: Self-reported subjective perception of intoxication reflects family history of alcoholism when breath alcohol levels are constant. Alcohol Clin Exp Res 26: 1299–1306, 2002.
Moy SS, Duncan GE, Knapp DJ, et al: Sensitivity to ethanol across development in rats: comparison to [3H]zolpidem binding. Alcohol Clin Exp Res 22:1485–1492, 1998.
Newlin DB, Thomson JB: Alcohol challenge with sons of alcoholics: a critical review and analysis. Psychol Bull 108: 383–402, 1990.
Osborne GL, Butler AC: Enduring effects of periadolescent alcohol exposure on passive avoidance performance in rats. Physiol Psychol 11:205–208, 1983.
Parisella RM, Pritham GH: Effect of age on alcohol preference by rats. Q J Stud Alcohol 25:248–252, 1964.
Philpot RM, Badanich KA, Kirstein CL: Place conditioning: Age-related changes in the rewarding and aversive effects of alcohol. Alcohol Clin Exp Res 27:593–599, 2003.
Pohorecky LA, Roberts P: Daily dose of ethanol and the development and decay of acute and chronic tolerance and physical dependence in rats. Pharmacol Biochem Behav 42:831–842, 1992.
Pottayil R, Spear LP: The effects of ethanol on spatial and non-spatial memory in adolescent and adult rats using an appetitive paradigm. Presented at a New York Academy of Sciences Conference, Adolescent Brain Development: Vulnerabilities and Opportunities, September, 2003, New York, NY.
Pyapali GK, Turner DA, Wilson WA, et al: Age and dose-dependent effects of ethanol on the induction of hippocampal long-term potentiation. Alcohol 19:107–111, 1999.
Raiha NC, Koskinen M, Pikkarainen P: Developmental changes in alcohol-dehydrogenase activity in rat and guinea-pig liver. Biochem 1103:623–626, 1967.
Rakic P, Bourgeois J-P, Goldman-Rakic PS: Synaptic development of the cerebral cortex: implications for learning, memory, and mental illness, in van Pelt J, Corner MA, Uylings HBM, Lopes da Silva FH (eds): Progress in Brain Research, The Self-Organizing Brain: From Growth Cones to Functional Networks, Vol. 102. Amsterdam, Elsevier, 1994, pp 227–243.
Ristuccia RC, Spear LP: Adolescent ethanol sensitivity: Hypothermia and acute tolerance. Presented at a New York Academy of Sciences Conference, Adolescent Brain Development: Vulnerabilities and Opportunities, September, 2003, New York, NY.
Schuckit MA: Low level of response to alcohol as a predictor of future alcoholism. Am J Psychiatry 151:184–189, 1994.
Siciliano D, Smith RF: Periadolescent alcohol alters adult behavioral characteristics in the rat. Physiol Behav 74:637–643, 2001.
Silveri MM, Spear LP: Decreased sensitivity to the hypnotic effects of ethanol early in ontogeny. Alcohol Clin Exp Res 22:670–676, 1998
Silveri MM, Spear LP: Ontogeny of rapid tolerance to the hypnotic effects of ethanol. Alcohol Clin Exp Res 23:1180–1184, 1999.
Silveri MM, Spear LP: Ontogeny of ethanol elimination and ethanol-induced hypothermia. Alcohol 20:45–53, 2000.
Silveri MM, Spear LP: Acute, rapid and chronic tolerance during ontogeny: Observations when equating ethanol perturbation across age. Alcohol Clin Exp Res 25:1301–1308, 2001.
Silveri MM, Spear LP: The effects of NMDA and GABAA pharmacological manipulations on ethanol sensitivity in immature and mature animals. Alcohol Clin Exp Res 26:449–456, 2002.
Silveri MM, Spear LP: The effects of NMDA and GABAA pharmacological manipulations on acute and rapid tolerance to ethanol during ontogeny. Alcohol Clin Exp Res, 28:884–894, 2004.
Slawecki CJ: Altered EEG responses to ethanol in adult rats exposed to ethanol during adolescence. Alcohol Clin Exp Res 26:246–254, 2002.
Slawecki CJ, Betancourt M, Cole M, et al: Periadolescent alcohol exposure has lasting effects on adult neurophysiological function in rats. Dev Brain Res 128:63–72, 2001.
Smith GT, Goldman MS, Greenbaum PE, et al: Expectancy for social facilitation from drinking: The divergent paths of high-expectancy and low-expectancy adolescents. J Abnorm Psychol 104:32–40, 1995.
Smith RF: Animal models of periadolescent substance abuse: review. Neurotoxicol Teratol 25:291–301, 2003.
Spear LP: The adolescent brain and age-related behavioral manifestations. Neurosci Biobehav Rev 24:417–463, 2000.
Spear LP: The adolescent brain and the college drinker: Biological basis of propensity to use and misuse alcohol. J Stud Alcohol Suppl 14:71–81, 2002.
Swartzwelder HS: The adolescent brain: unique ethanol sensitivity of NMDA receptor-mediated functions (this volume).
Swartzwelder HS, Richardson RC, Markwiese-Foerch B, et al: Developmental differences in the acquisition of tolerance to ethanol. Alcohol 15:1–4, 1998.
Swartzwelder HS, Wilson WA, Tayyeb MI: Age-dependent inhibition of long-term potentiation by ethanol in immature versus mature hippocampus. Alcohol Clin Exp Res 19:1480–1485, 1995a.
Swartzwelder HS, Wilson WA, Tayyeb MI: Differential sensitivity of NMDA receptor-mediated synaptic potentials to ethanol in immature versus mature hippocampus. Alcohol Clin Exp Res 19:320–323, 1995b.
Tapert SF: The human adolescent brain and alcohol use disorders (this volume).
Tentler JJ, LaPaglia N, Steiner J, et al: Ethanol, growth hormone and testosterone in peripubertal rats. J Endocrinol 152:477–487, 1997.
Tolliver GA, Samson HH: The influence of early postweaning ethanol exposure on oral self-administration behavior in the rat. Pharmacol Biochem Behav 38:575–580, 1991.
Varlinskaya EI, Spear LP: Acute effects of ethanol on social behavior of adolescent and adult rats: Role of familiarity of the test situation. Alcohol Clin Exp Res 26:1502–1511, 2002.
Varlinskaya EI, Spear LP: Age-and time-dependent effects of ethanol on social interactions: implications for the ontogeny of acute tolerance. Presented at the annual meeting of the Research Society on Alcoholism, June, 2003, Fort Lauderdale, FL.
Varlinskaya EI, Spear LP: Changes in sensitivity to ethanol-induced social facilitation and social inhibition from early to late adolescence. Annals of the New York Academy of Sciences, 1021:459–461, 2004a.
Varlinskaya EI, Spear LP: Acute ethanol withdrawal (hangover) and social behavior in adolescent and adult male and female rats. Alcohol Clin Exp Res, 28:40–50, 2004b.
Varlinskaya EI, Spear LP, Spear NE: Acute effects of ethanol on behavior of adolescent rats: Role of social context. Alcohol Clin Exp Res 25:377–385, 2001.
Wechsler H, Lee JE, Nelson TF, et al: Underage college students' drinking behavior, access to alcohol, and the influence of deterrence policies. Findings from the Harvard School of Public Health College Alcohol Study. J Am Coill Health 50:223–236, 2002.
White AM, Ghia AJ, Levin ED, et al: Binge pattern ethanol exposure in adolescent and adult rats: Differential impact on subsequent responsiveness to ethanol. Alcohol Clin Exp Res 24:1251–1256, 2000.
White AM, Truesdale MC, Bae JG, et al: Differential effects of ethanol on motor coordination in adolescent and adult rats. Pharmacol Biochem Behav 73:673–677, 2002a.
White AM, Bae JG, Truesdale MC, et al: Chronic-intermittent ethanol exposure during adolescence prevents normal developmental changes in sensitivity to ethanol-induced motor impairments. Alcohol Clin Exp Res 26:960–968, 2002b.
Zorzano A, Herrera E: Decreased in vivo rate of ethanol metabolism in the suckling rat. Alcohol Clin Exp Res 13:527–532, 1989.
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Spear, L.P., Varlinskaya, E.I. (2005). Adolescence. In: Galanter, M., Lowman, C., Boyd, G.M., Faden, V.B., Witt, E., Lagressa, D. (eds) Recent Developments in Alcoholism. Recent Developments in Alcoholism, vol 17. Springer, Boston, MA. https://doi.org/10.1007/0-306-48626-1_7
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